MAPK6 and MZB1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK6	MZB1
Description		mitogen-activated protein kinase 6	marginal zone B and B1 cell specific protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Positive Regulation Of Immunoglobulin Production Apoptotic Process Positive Regulation Of Cell Population Proliferation Regulation Of B Cell Proliferation Integrin Activation Regulation Of Cell Population Proliferation Regulation Of Insulin Receptor Signaling Pathway
Pathways		MAPK6/MAPK4 signaling
Drugs		Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Malaria ( 31844061)
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	4 interacting genes: CASP2 CASP9 MAPK6 TSG101
Entrez ID		5597	51237
HPRD ID		04213	17815
Ensembl ID		ENSG00000069956	ENSG00000170476
Uniprot IDs		Q16659	B3KQ72 Q8WU39
PDB IDs		6YKY 6YLC 6YLL 7AQB	7AAH
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	Positive Regulation Of Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity Intrinsic Apoptotic Signaling Pathway Signal Transduction In Response To DNA Damage Protein Processing Endopeptidase Complex Apoptosome Caspase Complex Septin Cytoskeleton Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Protein Metabolic Process Exosomal Secretion Luteolysis Regulation Of Neuron Apoptotic Process Proteolysis Response To Anesthetic Glial Cell Apoptotic Process Response To Indole-3-methanol Regulation Of Extracellular Exosome Assembly Protein Maturation Apoptotic Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Cobalt Ion Virion Binding Fibroblast Apoptotic Process ESCRT I Complex Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Exosomal Secretion Ectopic Germ Cell Programmed Cell Death Peptidase Activity Neural Retina Development Intracellular Signal Transduction Protein Kinase Binding MAP Kinase Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Exosomal Secretion Negative Regulation Of Peptidyl-tyrosine Phosphorylation Programmed Cell Death Involved In Cell Development Positive Regulation Of Execution Phase Of Apoptosis Viral Budding Via Host ESCRT Complex Regulation Of Protein Tyrosine Kinase Activity Platelet Formation Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Macromolecule Metabolic Process Execution Phase Of Apoptosis
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