MAPK6 and PSIP1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MAPK6	PSIP1
Gene Name		mitogen-activated protein kinase 6	PC4 and SFRS1 interacting protein 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Nuclear Heterochromatin Nucleolus Cytosol Nuclear Periphery Transcriptionally Active Chromatin
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity	RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Protein Binding Activating Transcription Factor Binding Poly(A) RNA Binding Supercoiled DNA Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction	MRNA 5'-splice Site Recognition Transcription, DNA-templated Regulation Of Transcription, DNA-templated Response To Oxidative Stress Response To Heat Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Integrated Proviral Latency
Pathways			Autointegration results in viral DNA circles HIV Life Cycle Vpr-mediated nuclear import of PICs HIV Infection Host Interactions of HIV factors Integration of provirus 2-LTR circle formation Interactions of Vpr with host cellular proteins Integration of viral DNA into host genomic DNA APOBEC3G mediated resistance to HIV-1 infection Early Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		167 interactors: ACTG1 ACTR1B AMPH ANAPC5 ANK3 APBA2 APOA1 APOA1BP ARHGDIA ARPC3 ATG9A ATP5J BAG6 BARX1 BBS10 C21orf59 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFL1 CNTN1 CNTRL COPS6 CSE1L CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DSCR3 DST EDF1 EEF1A2 EGLN3 EIF1 EIF3C EIF4A1 ELOF1 EMD FAM49B FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GNB2L1 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NDUFS6 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLK1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 PVRL2 RAB2A RAB31 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPT3 SEPT5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 WDR26 WDR34 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	10 interactors: CASP3 CASP7 CSNK2A1 HCFC1 HMGA1 HMGA2 MAPK6 SP1 SRSF1 SUB1
Entrez ID		5597	11168
HPRD ID		04213	04688
Ensembl ID		ENSG00000069956	ENSG00000164985
Uniprot IDs		Q16659	O75475
PDB IDs		2I6L	1Z9E 2B4J 2M16 3F9K 3HPG 3HPH 3U88 3ZEH 4FU6
Enriched GO Terms of Interacting Partners?		Cell Cycle Cellular Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Cellular Metabolic Process Cell Cycle Process Gene Expression Regulation Of Metabolic Process Regulation Of Catalytic Activity Response To Organic Substance Cellular Component Assembly Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Immune Response Regulation Of Immune System Process Cellular Macromolecule Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Biosynthetic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Response To Wounding Negative Regulation Of Signal Transduction RNA Metabolic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Cell Division RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated	Oncogene-induced Cell Senescence Senescence-associated Heterochromatin Focus Assembly Positive Regulation Of Cellular Senescence Positive Regulation Of Cell Aging Positive Regulation Of Metabolic Process DNA Catabolic Process, Endonucleolytic Transcription, DNA-templated RNA Biosynthetic Process Heterochromatin Assembly Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Heterochromatin Organization DNA Catabolic Process Regulation Of Cellular Senescence Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Cellular Senescence Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Heterocycle Metabolic Process Interaction With Symbiont Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Base-excision Repair Regulation Of Viral Transcription Regulation Of Cell Cycle Cell Aging Execution Phase Of Apoptosis Positive Regulation Of Cellular Response To X-ray Sequestering Of Nodal From Receptor Via Nodal Binding Mesodermal-endodermal Cell Signaling Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Histone H2A-S139 Phosphorylation Chromosome Breakage Regulation Of Transcription, DNA-templated Regulation Of Endopeptidase Activity Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging	aggressive arid1a arise carcinoids copy covalent drive exome far inactivation lung men1 modifiers mutated neuroendocrine observe perform progenitor pulmonary rare rb1 recurrently remodelling snf swi systematically tp53 transcriptome tumours
Tagcloud (Difference) ?		astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging	aggressive arid1a arise carcinoids copy covalent drive exome far inactivation lung men1 modifiers mutated neuroendocrine observe perform progenitor pulmonary rare rb1 recurrently remodelling snf swi systematically tp53 transcriptome tumours
Tagcloud (Intersection) ?