MAPK6 and MASP1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK6	MASP1
Description		mitogen-activated protein kinase 6	MBL associated serine protease 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Extracellular Region Extracellular Space Nucleoplasm Cytosol Symbiont Cell Surface
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Negative Regulation Of Complement Activation Protein Maturation
Pathways		MAPK6/MAPK4 signaling	Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1
Entrez ID		5597	5648
HPRD ID		04213	02749
Ensembl ID		ENSG00000069956	ENSG00000127241
Uniprot IDs		Q16659	P48740
PDB IDs		6YKY 6YLC 6YLL 7AQB	3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD 7PQO
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Complement Activation Positive Regulation Of Phagocytosis Response To Stress Regulation Of Phagocytosis Classical-complement-pathway C3/C5 Convertase Complex Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Regulation Of Immune Response Positive Regulation Of Endocytosis Ribosomal Protein S6 Kinase Activity Cell Killing Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Opsonization Signal Complex Assembly Activation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Cellular Component Organization Regulation Of Apoptotic Cell Clearance Regulation Of Opsonization Serine-type Endopeptidase Complex Regulation Of Innate Immune Response Protein Kinase Binding Complement Activation, GZMK Pathway TOR Signaling Regulation Of Defense Response Humoral Immune Response Regulation Of Cellular Response To Heat Dynactin Binding Regulation Of Cellular Response To Stress Regulation Of Endocytosis Protein Maturation Blood Microparticle Regulation Of Translation In Response To Stress Regulation Of Complement Activation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Signal Transduction Immune Response-activating Signaling Pathway Protein Serine Kinase Activity Cellular Response To Stress Signal Transduction In Response To DNA Damage Immune Effector Process Protein Metabolic Process Protein Serine/threonine Kinase Activity Response To Bacterium Regulation Of Multicellular Organismal Process
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