MAPK6 and PRKAB1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK6	PRKAB1
Description		mitogen-activated protein kinase 6	protein kinase AMP-activated non-catalytic subunit beta 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Protein Binding Protein Kinase Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Cellular Response To Nutrient Levels Nail Development Positive Regulation Of Cold-induced Thermogenesis
Pathways		MAPK6/MAPK4 signaling	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		Acetylsalicylic acid Minocycline Colforsin	Adenosine phosphate Adenosine phosphate Metformin Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Basophil count ( 32888494) Inflammatory bowel disease ( 26192919) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Ulcerative colitis ( 26192919) White blood cell count ( 32888494)
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	13 interacting genes: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2 SLC31A1
Entrez ID		5597	5564
HPRD ID		04213	04116
Ensembl ID		ENSG00000069956	ENSG00000111725
Uniprot IDs		Q16659	Q9Y478
PDB IDs		6YKY 6YLC 6YLL 7AQB	4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6C9F 6C9G 6C9H 6C9J 7MYJ 8BIK
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	AMP-activated Protein Kinase Activity Nucleotide-activated Protein Kinase Complex Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Fatty Acid Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Glucose Starvation Positive Regulation Of Small Molecule Metabolic Process Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Glycolytic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Cellular Response To Prostaglandin Stimulus Carboxylic Acid Biosynthetic Process Response To Prostaglandin E Phosphate-containing Compound Metabolic Process Regulation Of Carbon Utilization Fatty Acid Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Small Molecule Metabolic Process Protein Localization To Lipid Droplet Sterol Biosynthetic Process Negative Regulation Of Tubulin Deacetylation CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Cellular Response To Starvation Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly CAMP-dependent Protein Kinase Regulator Activity Small Molecule Biosynthetic Process Protein Kinase Binding Monocarboxylic Acid Metabolic Process Response To Starvation Response To Nutrient Levels Phosphatidylethanolamine Biosynthetic Process ATP Binding Organophosphate Biosynthetic Process Lipid Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Cellular Response To Nutrient Levels Steroid Biosynthetic Process AMP Binding Positive Regulation Of TOR Signaling Response To Hormone Intracellular Copper Ion Homeostasis Protein Kinase Regulator Activity
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