PPP2R1A and PPP2R2A

Number of citations of the paper that reports this interaction (PMID 17632056)
92

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		PPP2R1A	PPP2R2A
Gene Name		protein phosphatase 2, regulatory subunit A, alpha	protein phosphatase 2, regulatory subunit B, alpha
Image
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Mitochondrion Cytosol Microtubule Cytoskeleton Membrane Extracellular Vesicular Exosome	Protein Phosphatase Type 2A Complex Nucleoplasm Cytosol
	Molecular Function	Antigen Binding Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity Protein Heterodimerization Activity	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Complex Assembly Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Organelle Organization Chromosome Segregation Mitotic Nuclear Envelope Reassembly RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway Response To Organic Substance Gene Expression Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cell Differentiation Peptidyl-serine Dephosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Mitotic Cell Cycle Protein Dephosphorylation Mitotic Nuclear Envelope Reassembly Signal Transduction Gene Expression Response To Morphine Regulation Of Catalytic Activity
Pathways		Signaling by FGFR in disease Integration of energy metabolism misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated Toll Like Receptor TLR1:TLR2 Cascade Glucose metabolism Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated MyD88 dependent cascade initiated on endosome Glycogen storage diseases Beta-catenin phosphorylation cascade Mitotic G1-G1/S phases Recruitment of mitotic centrosome proteins and complexes misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling S45 mutants of beta-catenin aren't phosphorylated Spry regulation of FGF signaling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Platelet sensitization by LDL Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Adaptive Immune System MASTL Facilitates Mitotic Progression Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding G2/M Transition disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Innate Immune System Nonsense-Mediated Decay (NMD) E2F mediated regulation of DNA replication ERKs are inactivated G1 Phase CTLA4 inhibitory signaling Signaling by FGFR Cyclin D associated events in G1 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Signaling by GPCR Mitotic Prophase TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt Glycolysis Regulation of PLK1 Activity at G2/M Transition RNF mutants show enhanced WNT signaling and proliferation G1/S Transition Myoclonic epilepsy of Lafora Toll Like Receptor 9 (TLR9) Cascade Initiation of Nuclear Envelope Reformation ERK/MAPK targets truncations of AMER1 destabilize the destruction complex Negative regulation of FGFR signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Mitotic Metaphase and Anaphase PP2A-mediated dephosphorylation of key metabolic factors Mitotic Prometaphase Organelle biogenesis and maintenance Costimulation by the CD28 family Toll Like Receptor 7/8 (TLR7/8) Cascade Mitotic Anaphase APC truncation mutants are not K63 polyubiquitinated M Phase Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane DARPP-32 events Nuclear Envelope Reassembly Signalling by NGF MAP kinase activation in TLR cascade Assembly of the primary cilium NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Centrosome maturation Nuclear Events (kinase and transcription factor activation)	Nonsense-Mediated Decay (NMD) G1 Phase G2/M Transition Mitotic Anaphase Cell Cycle, Mitotic M Phase Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Cyclin D associated events in G1 Cyclin A/B1 associated events during G2/M transition Nuclear Envelope Reassembly Initiation of Nuclear Envelope Reformation Mitotic G2-G2/M phases Mitotic G1-G1/S phases Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			Height ( 23563607)
Protein-Protein Interactions		39 interactors: AIMP2 AKT1 ARIH2 CDK1 CSDC2 EEF2 GNA12 GRIN1 GRIN2D HSF2 HSPD1 IPO9 MAP3K7 MAPK6 MCM3 PARK7 PLA2G16 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP4C PPP5C PRDX1 PRDX2 RAB11A RAB18 RAB7A RAP1A SGOL1 SGOL2 SLC6A2 SMAD2 SMAD3 STRN STRN3 TAB1 TRADD ZFYVE9	12 interactors: ATR CHEK2 GRIN1 GRIN2D MTOR NDRG1 PPP2CA PPP2R1A PPP2R1B RRN3 STRN3 TGFBR1
Entrez ID		5518	5520
HPRD ID		16184	09223
Ensembl ID			ENSG00000221914
Uniprot IDs		A8K7B7 P30153	P63151
PDB IDs		1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N	3DW8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Ras Protein Signal Transduction Signaling Intracellular Signal Transduction Signal Transduction Cell Communication Positive Regulation Of Cellular Metabolic Process SMAD Protein Complex Assembly Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cellular Response To Stimulus Cell Cycle Process Response To Organic Substance Cell Cycle Mitotic Cell Cycle Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Stimulus Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Protein Complex Assembly Regulation Of Protein Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Metabolic Process Response To Organic Cyclic Compound Positive Regulation Of Protein Kinase Activity Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Modification Process Response To Transforming Growth Factor Beta Positive Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Cellular Response To Reactive Oxygen Species Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Hydrogen Peroxide Metabolic Process Programmed Cell Death Cellular Component Assembly Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Localization Toll-like Receptor Signaling Pathway	Regulation Of DNA Replication Regulation Of Signaling Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Mitotic Nuclear Envelope Reassembly Regulation Of Signal Transduction Nuclear Envelope Reassembly Positive Regulation Of Transcription, DNA-templated Peptidyl-serine Phosphorylation Nucleus Organization Replicative Senescence Positive Regulation Of Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Gene Expression Double-strand Break Repair Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Cellular Biosynthetic Process Apoptotic Process Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Startle Response Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Process Regulation Of Intracellular Signal Transduction Cell Death Regulation Of Cellular Response To Heat Death Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Fibroblast Growth Factor Negative Regulation Of Signal Transduction Inactivation Of MAPK Activity Cell Development Response To Abiotic Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intracellular Signal Transduction Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Cellular Component Organization Negative Regulation Of Signaling Positive Regulation Of Cell Death Developmental Process Synaptic Transmission, Glutamatergic
Tagcloud ?		arid1a carcinomas ccc concurrent constitute ctnnb1 endometrial endometrioid endometrium hepatocyte hnf1beta immunophenotype mismatch morphologically mutated napsin oestrogen oncogenesis pole predominance prototypical pten pure rigorously serous tp53 tumours twelve underscore	22q13 alterations analyzing brca1 candidates computational developments drive driver estimates estimating generations genomes genomic identifies instability lineage mutator mutators neutral passenger passengers prkdc somatic take technologies throughput timing tumorigenesis
Tagcloud (Difference) ?		arid1a carcinomas ccc concurrent constitute ctnnb1 endometrial endometrioid endometrium hepatocyte hnf1beta immunophenotype mismatch morphologically mutated napsin oestrogen oncogenesis pole predominance prototypical pten pure rigorously serous tp53 tumours twelve underscore	22q13 alterations analyzing brca1 candidates computational developments drive driver estimates estimating generations genomes genomic identifies instability lineage mutator mutators neutral passenger passengers prkdc somatic take technologies throughput timing tumorigenesis
Tagcloud (Intersection) ?