MAPK6 and SNAPC4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK6	SNAPC4
Description		mitogen-activated protein kinase 6	small nuclear RNA activating complex polypeptide 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Nucleus Nucleoplasm SnRNA-activating Protein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase III General Transcription Initiation Factor Activity RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III
Pathways		MAPK6/MAPK4 signaling	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs		Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Crohn's disease ( 21102463 22936669 28067908) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Joint damage in rheumatoid arthritis ( 26498133) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Neutrophil percentage of white cells ( 32888494) Takayasu arteritis ( 33308445) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	8 interacting genes: BRF2 HNRNPD MAPK6 POU2F1 SNAPC1 SNAPC2 SNAPC5 TBP
Entrez ID		5597	6621
HPRD ID		04213	04146
Ensembl ID		ENSG00000069956	ENSG00000165684
Uniprot IDs		Q16659	Q5SXM2
PDB IDs		6YKY 6YLC 6YLL 7AQB	7XUR 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	RNA Polymerase II General Transcription Initiation Factor Activity Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity SnRNA Transcription Transcription By RNA Polymerase II DNA-templated Transcription SnRNA Metabolic Process DNA-templated Transcription Initiation SnRNA Transcription By RNA Polymerase III RNA Metabolic Process Nucleoplasm SnRNA Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Nucleus Transcription Preinitiation Complex Assembly Hepatocyte Dedifferentiation Cellular Response To Putrescine Macromolecule Metabolic Process Circadian Regulation Of Translation Septin Cytoskeleton SnRNA-activating Protein Complex Transcription Factor TFIIIB Complex TFIIB-class Transcription Factor Binding Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Response To Rapamycin Cell Dedifferentiation RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding Pronucleus Protein-DNA Complex Assembly Transcription Initiation At RNA Polymerase III Promoter Male Pronucleus Aryl Hydrocarbon Receptor Binding Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Female Pronucleus CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Female Germ Cell Nucleus Transcription Preinitiation Complex Regulation Of Telomere Capping
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