MAPK6 and CNTRL

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		MAPK6	CNTRL
Description		mitogen-activated protein kinase 6	centriolin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Centriolar Satellite Ciliary Basal Body Perinuclear Region Of Cytoplasm Meiotic Spindle Flemming Body Meiotic Spindle Pole Mitotic Spindle Pole Centriolar Subdistal Appendage
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Kidney Development Cardiac Septum Development Ventricular Septum Development Aorta Development Cell Division Coronary Vasculature Development
Pathways		MAPK6/MAPK4 signaling	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Pulse pressure ( 27841878)
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	5 interacting genes: CREBBP MAP3K4 MAPK6 TRADD TSC1
Entrez ID		5597	11064
HPRD ID		04213	05691
Ensembl ID		ENSG00000069956	ENSG00000119397
Uniprot IDs		Q16659	B2RP65 Q5JVD1 Q7Z7A1
PDB IDs		6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	Histone H3K18 Acetyltransferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Signal Transduction Intracellular Signaling Cassette N-terminal Peptidyl-lysine Acetylation Response To Oxygen Levels Intracellular Signal Transduction Positive Regulation Of Signaling Histone H3K27 Acetyltransferase Activity Response To Decreased Oxygen Levels Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Canonical NF-kappaB Signal Transduction Atrioventricular Canal Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Intracellular Signal Transduction Endothelial Microparticle Galactose Binding Endocardial Cushion To Mesenchymal Transition Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Detection Of Hypoxia Primary Sex Determination Male Germ-line Sex Determination Posterior Compartment Specification Compartment Pattern Specification Anterior Compartment Pattern Formation Adult Locomotory Behavior Septin Cytoskeleton Signaling Adaptor Activity Tumor Necrosis Factor-mediated Signaling Pathway Memory T Cell Differentiation TSC1-TSC2 Complex Tumor Necrosis Factor Receptor Superfamily Complex Death Domain Binding MRF Binding Cardiac Atrium Morphogenesis Detection Of Oxygen Central Nervous System Vasculogenesis Dorsal Spinal Cord Development Adult Behavior ATPase Inhibitor Activity Regulation Of Cell Communication Response To UV Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
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