PPP2R1A and IPO9

Number of citations of the paper that reports this interaction (PubMedID 12670497)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PPP2R1A	IPO9
Description		protein phosphatase 2 scaffold subunit Aalpha	importin 9
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Chromatin Nucleus Chromosome Cytoplasm Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Cell Projection Neuron Projection Neuronal Cell Body Synapse Extracellular Exosome FAR/SIN/STRIPAK Complex Glutamatergic Synapse INTAC Complex	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding	Protein Binding Small GTPase Binding Histone Binding Nuclear Import Signal Receptor Activity Histone Chaperone Activity
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Chromosome Segregation Female Meiotic Nuclear Division Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Regulation Of Growth T Cell Homeostasis Regulation Of Cell Differentiation Spindle Assembly Meiotic Spindle Elongation Mitotic Sister Chromatid Separation Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Assembly RNA Polymerase II Transcription Initiation Surveillance Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Import Into Nucleus Intracellular Protein Transport Proteasomal Protein Catabolic Process Protein Transport Proteasome Localization
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS			Adult body size ( 32376654) Myocardial infarction ( 33532862) Sleep duration (short sleep) ( 30846698) Waist circumference ( 31928498)
Interacting Genes		59 interacting genes: AIMP2 AKT1 AMOTL2 ARIH2 ATM CARD11 CARHSP1 CDC42 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 DUX4 EEF2 ESR1 FBXO43 GNA12 GOLGA6A GOLGA8F GRIN1 GRIN2D HSF2 HSPD1 IPO9 LINC01554 MAP3K7 MAPK6 MCM3 OGT PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP4C PPP5C PRDX1 PRDX2 PTPA RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC25A21-AS1 SLC6A2 SMAD2 SMAD3 STRN STRN3 SUMO2 TAB1 TRADD ZFYVE9	8 interacting genes: APP FBXO7 LINC01554 MTDH MTNR1A MTNR1B PPP2R1A RAN
Entrez ID		5518	55705
HPRD ID		16184	17154
Ensembl ID		ENSG00000105568	ENSG00000198700
Uniprot IDs		A8K7B7 B3KQV6 P30153	Q96P70
PDB IDs		1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W 6IUR 6NTS 7CUN 7K36 7PKS 7SOY 7YCX 8RBX 8RBZ 8RC4 8SO0 8TTB 8TWE 8TWI 8U1X 8U89 8UWB 8YJB	6N1Z 8F7A
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex Intracellular Signal Transduction Intracellular Signaling Cassette Cytosol Protein Phosphatase 2A Binding Cytoplasm Protein Phosphatase Regulator Activity Signal Transduction Peroxiredoxin Activity Cellular Response To Oxygen-containing Compound Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Glutamatergic Synapse Response To Oxidative Stress G Protein Activity Positive Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Cell Communication Regulation Of Signaling Response To Growth Factor Cellular Response To Nerve Growth Factor Stimulus Tau Protein Binding Response To Nerve Growth Factor Removal Of Superoxide Radicals Response To Reactive Oxygen Species Positive Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signaling Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Regulation Of Programmed Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding GTP Binding Protein Phosphatase Activator Activity Phosphatase Binding Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Regulation Of Protein Catabolic Process Cellular Response To Growth Factor Stimulus Peptidyl-threonine Phosphorylation Calmodulin Binding Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Localization	Melatonin Receptor Activity Protein Heterodimerization Activity Mating Behavior Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Reproductive Behavior G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Meiotic Spindle Elongation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Regulation Of Protein Transport Positive Regulation Of Protein Import Regulation Of Intracellular Signal Transduction Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lewy Body Core Regulation Of Establishment Of Protein Localization Positive Regulation Of Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Recycling Endosome Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling
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