MAPK6 and PHACTR3

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		MAPK6	PHACTR3
Name		mitogen-activated protein kinase 6	phosphatase and actin regulator 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Nucleus Nucleoplasm Nuclear Matrix
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Actin Cytoskeleton Organization
Pathways		MAPK6/MAPK4 signaling	None
Drugs		Acetylsalicylic acid Minocycline Colforsin	None
GWAS		Frailty index ( 34431594 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 )	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 30891314 ) Schizophrenia ( 30285260 )
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	10 interacting genes: CAPNS2 CYB5B EEF1G MAPK6 PLPP6 PPP1CA PPP1CB TAB1 UBIAD1 UBL5
Entrez ID		5597	116154
HPRD ID		04213	10571
Ensembl ID		ENSG00000069956	ENSG00000087495
Uniprot IDs		Q16659	B7Z339 Q96KR7
PDB IDs		6YKY 6YLC 6YLL 7AQB	Not available
GO Terms Enriched among Interactors		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	PTW/PP1 Phosphatase Complex Protein Serine/threonine Phosphatase Activity Dephosphorylation Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Glycogen Metabolic Process Myosin-light-chain-phosphatase Activity Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Protein Dephosphorylation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Septin Cytoskeleton Protein Modification Process Lung Development Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Nitric-oxide Synthase Complex Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Regulation Of Circadian Rhythm Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Myosin Phosphatase Activity Endoplasmic Reticulum Membrane Calpain Complex Protein Metabolic Process Phosphoprotein Phosphatase Activity Circadian Rhythm Nitrite Reductase (NO-forming) Activity Lipid Phosphatase Activity Glycogen Granule Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Menaquinone Metabolic Process Farnesyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding Lysophosphatidic Acid Phosphatase Activity RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Chromosome, Telomeric Region Positive Regulation Of CGAS/STING Signaling Pathway Energy Derivation By Oxidation Of Organic Compounds Double-strand Break Repair Via Alternative Nonhomologous End Joining