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FBXL12 and PSEN1
Number of citations of the paper that reports this interaction (PMID
21163940
)
13
Data Source:
BioGRID
(two hybrid)
FBXL12
PSEN1
Gene Name
F-box and leucine-rich repeat protein 12
presenilin 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Cytoplasm
Golgi Membrane
Kinetochore
Nuclear Outer Membrane
Mitochondrion
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Integral Component Of Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Integral Component Of Membrane
Apical Plasma Membrane
Z Disc
Axon
Growth Cone
Cytoplasmic Vesicle
Neuromuscular Junction
Nuclear Membrane
Ciliary Rootlet
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Perinuclear Region Of Cytoplasm
Gamma-secretase Complex
Molecular Function
Protein Binding
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Calcium Channel Activity
Protein Binding
Beta-catenin Binding
PDZ Domain Binding
Cadherin Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Autophagic Vacuole Assembly
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Activation Of MAPKK Activity
Blood Vessel Development
Cell Fate Specification
Somitogenesis
Neuron Migration
Positive Regulation Of Receptor Recycling
Heart Looping
Hematopoietic Progenitor Cell Differentiation
T Cell Activation Involved In Immune Response
Protein Glycosylation
Membrane Protein Ectodomain Proteolysis
Mitochondrial Transport
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Notch Signaling Pathway
Notch Receptor Processing
Memory
Post-embryonic Development
Protein Transport
L-glutamate Transport
Choline Transport
Synaptic Vesicle Targeting
Single Organismal Cell-cell Adhesion
Protein Processing
Cerebral Cortex Cell Migration
Cajal-Retzius Cell Differentiation
Dorsal/ventral Neural Tube Patterning
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Embryonic Limb Morphogenesis
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Beta-amyloid Formation
Intracellular Signal Transduction
Regulation Of Phosphorylation
Amyloid Precursor Protein Catabolic Process
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Regulation Of Protein Binding
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Skin Morphogenesis
Regulation Of Synaptic Plasticity
Thymus Development
Neuron Development
Skeletal System Morphogenesis
Brain Morphogenesis
Beta-amyloid Metabolic Process
Epithelial Cell Proliferation
Negative Regulation Of Axonogenesis
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Neuron Apoptotic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Synaptic Transmission, Glutamatergic
Canonical Wnt Signaling Pathway
Regulation Of Resting Membrane Potential
Calcium Ion Transmembrane Transport
Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions
14 interactors:
A2M
APOE
CDC37
CDKN1C
DOCK8
ECSIT
FXYD3
LNX1
MAST1
PSEN1
PSEN2
RNF32
SMAD1
TGFBR1
91 interactors:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
DSP
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
SCAF11
SCN1A
ST13
STAMBPL1
TCF4
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
Entrez ID
54850
5663
HPRD ID
12363
00087
Ensembl ID
ENSG00000127452
ENSG00000080815
Uniprot IDs
Q9NXK8
P49768
PDB IDs
2KR6
Enriched GO Terms of Interacting Partners
?
Regulation Of Catalytic Activity
Embryonic Morphogenesis
Intracellular Signal Transduction
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Thymus Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Generation Of Neurons
Amyloid Precursor Protein Catabolic Process
Anatomical Structure Morphogenesis
Neurogenesis
Regulation Of Protein Phosphorylation
Cell Fate Commitment
Neuron Differentiation
Embryo Development
Negative Regulation Of Protein Phosphorylation
Cell Activation
Response To Wounding
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorylation
Beta-amyloid Metabolic Process
Amyloid Precursor Protein Metabolic Process
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Phosphorylation
Membrane Protein Ectodomain Proteolysis
Notch Receptor Processing
Response To Cholesterol
Regulation Of Protein Binding
Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Nervous System Development
Regulation Of Cell Death
Regulation Of Synaptic Plasticity
Regulation Of Cell Morphogenesis
Pattern Specification Process
Regulation Of Cell Projection Organization
Neuron Development
Gland Development
Cell Differentiation
Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Metabolic Process
Response To Stress
Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Endothelial Cell Proliferation
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Cell Death
Regulation Of Apoptotic Process
Cell Development
Notch Receptor Processing
Nervous System Development
Generation Of Neurons
Cell Differentiation
Regulation Of Signaling
Positive Regulation Of Cell Death
Neurogenesis
Positive Regulation Of Catalytic Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
System Development
Execution Phase Of Apoptosis
Neuron Differentiation
Anatomical Structure Development
Multicellular Organismal Development
Cellular Response To Stimulus
Regulation Of Catalytic Activity
Anatomical Structure Morphogenesis
Negative Regulation Of Cell Death
Developmental Process
Neuron Projection Development
Negative Regulation Of Programmed Cell Death
Neuron Development
Signaling
Response To Stimulus
Regulation Of Signal Transduction
Regulation Of Neurogenesis
Regulation Of Cell Differentiation
Cell Communication
Regulation Of Protein Localization
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Response To Stress
Regulation Of Establishment Of Protein Localization
Notch Signaling Pathway
Positive Regulation Of Proteolysis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Cell Development
Cell Projection Organization
Negative Regulation Of Cell Differentiation
Positive Regulation Of Signal Transduction
Cell Morphogenesis Involved In Differentiation
Regulation Of Cellular Localization
Tagcloud
?
1795g
2125g
abeta37
abeta39
abeta40
advance
dementia
dementias
doi
e599k
ejhg
fus
g709s
genetics
genotyping
granulin
grn
harbored
hek293
journal
lewy
mapt
neuropathological
pd
publically
publication
shifted
tar
variants
Tagcloud (Difference)
?
1795g
2125g
abeta37
abeta39
abeta40
advance
dementia
dementias
doi
e599k
ejhg
fus
g709s
genetics
genotyping
granulin
grn
harbored
hek293
journal
lewy
mapt
neuropathological
pd
publically
publication
shifted
tar
variants
Tagcloud (Intersection)
?