FBXL12 and ZNF823

Data Source: HiPPIP (Novel)

		FBXL12	ZNF823
Name		F-box and leucine rich repeat protein 12	zinc finger protein 823
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol	Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	None
GWAS		Pursuit maintenance gain ( 29064472 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Hodgkin's lymphoma ( 34216518 )
Novel Interactors		5 novel interactors: MARCHF2 SHFL ZNF44 ZNF562 ZNF823	1 novel interactors: FBXL12
Interacting Genes		19 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FBF1 FXYD3 GEMIN4 LNX1 MAST1 PSEN1 PSEN2 PSME3 RNF32 SMAD1 TGFBR1 UBE2D3	1 interacting genes: PAK1
Entrez ID		54850	55552
HPRD ID		12363	19208
Ensembl ID		ENSG00000127452	ENSG00000197933
Uniprot IDs		Q9NXK8	P16415
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Amyloid Precursor Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Regulation Of Amyloid Fibril Formation I-SMAD Binding Amyloid Precursor Protein Catabolic Process	Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Protein Targeting To Membrane Regulation Of Fibroblast Migration Regulation Of Microtubule Nucleation Positive Regulation Of Microtubule Nucleation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of Muscle Hypertrophy Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Microtubule Polymerization Protein Localization To Cytoplasmic Stress Granule Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Axon Extension Negative Regulation Of Organ Growth Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Fibroblast Migration Gamma-tubulin Binding Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Tissue Growth Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy Fc Receptor Mediated Stimulatory Signaling Pathway Intercalated Disc Cerebellum Development Positive Regulation Of Stress Fiber Assembly Ephrin Receptor Signaling Pathway Regulation Of Heart Growth Collagen Binding Regulation Of Microtubule Polymerization Regulation Of Smooth Muscle Cell Migration Fc Receptor Signaling Pathway Negative Regulation Of Muscle Cell Differentiation Wound Healing Positive Regulation Of Axonogenesis Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Axon Extension