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PSEN1 and HMGB1
Number of citations of the paper that reports this interaction (PubMedID
21163940
)
58
Data Source:
BioGRID
(two hybrid)
PSEN1
HMGB1
Description
presenilin 1
high mobility group box 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Kinetochore
Nucleus
Nuclear Outer Membrane
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosomal Membrane
Endosome
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Cell Cortex
Synaptic Vesicle
Cell Surface
Membrane
Aggresome
Cell Junction
Axon
Dendrite
Growth Cone
Cytoplasmic Vesicle
Neuromuscular Junction
Early Endosome Membrane
Nuclear Membrane
Protein-containing Complex
Ciliary Rootlet
Azurophil Granule Membrane
Sarcolemma
Presynaptic Membrane
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Synapse
Gamma-secretase Complex
Synaptic Membrane
Postsynapse
Glutamatergic Synapse
Condensed Chromosome
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Endosome
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Cell Surface
Membrane
Transcription Repressor Complex
Secretory Granule Lumen
Alphav-beta3 Integrin-HMGB1 Complex
Neuron Projection
Ficolin-1-rich Granule Lumen
Molecular Function
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Calcium Channel Activity
Protein Binding
Beta-catenin Binding
Peptidase Activity
Hydrolase Activity
PDZ Domain Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Cadherin Binding
ATPase Binding
Growth Factor Receptor Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Transcription Cis-regulatory Region Binding
Lipopolysaccharide Binding
Phosphatidylserine Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Cytokine Activity
Integrin Binding
Protein Binding
Lipid Binding
DNA Binding, Bending
Calcium-dependent Protein Kinase Regulator Activity
Lyase Activity
C-X-C Chemokine Binding
Protein Kinase Activator Activity
Chemoattractant Activity
Receptor Ligand Activity
RAGE Receptor Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA Polymerase Binding
Supercoiled DNA Binding
DNA-binding Transcription Factor Binding
Biological Process
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Development
Cell Fate Specification
Somitogenesis
Neuron Migration
Positive Regulation Of Receptor Recycling
Heart Looping
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Hematopoietic Progenitor Cell Differentiation
Astrocyte Activation Involved In Immune Response
T Cell Activation Involved In Immune Response
Myeloid Leukocyte Differentiation
Neural Retina Development
Protein Glycosylation
Proteolysis
Membrane Protein Ectodomain Proteolysis
Mitochondrial Transport
Intracellular Calcium Ion Homeostasis
Autophagy
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Cell Adhesion
Notch Signaling Pathway
Notch Receptor Processing
Brain Development
Heart Development
Learning Or Memory
Memory
Post-embryonic Development
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Neuron Projection Development
Protein Transport
Choline Transport
Synaptic Vesicle Targeting
Protein Processing
Cerebellum Development
Cerebral Cortex Cell Migration
Cajal-Retzius Cell Differentiation
Dorsal/ventral Neural Tube Patterning
Cerebral Cortex Development
Neurogenesis
Neuron Differentiation
Embryonic Limb Morphogenesis
Forebrain Development
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Tumor Necrosis Factor Production
Amyloid-beta Formation
Segmentation
Intracellular Signal Transduction
Locomotion
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Skin Morphogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Astrocyte Activation
Regulation Of Synaptic Plasticity
Thymus Development
Neuron Development
Skeletal System Morphogenesis
Brain Morphogenesis
Amyloid-beta Metabolic Process
Epithelial Cell Proliferation
Negative Regulation Of Axonogenesis
Synapse Organization
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Sequestering Of Calcium Ion
Neuron Apoptotic Process
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Protein Maturation
Regulation Of Synaptic Transmission, Glutamatergic
Calcium Ion Homeostasis
Regulation Of Resting Membrane Potential
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Dendritic Spine Development
Neuron Cellular Homeostasis
Calcium Ion Transmembrane Transport
Apoptotic Signaling Pathway
Cell-cell Adhesion
Regulation Of Synaptic Vesicle Cycle
L-glutamate Import Across Plasma Membrane
Regulation Of Postsynapse Organization
Protein Catabolic Process At Postsynapse
Cellular Response To Amyloid-beta
Negative Regulation Of Core Promoter Binding
Positive Regulation Of Amyloid Fibril Formation
Neuron Projection Maintenance
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Eye Development
Myeloid Dendritic Cell Activation
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Activation Of Innate Immune Response
Adaptive Immune Response
Plasmacytoid Dendritic Cell Activation
Macrophage Activation Involved In Immune Response
Myeloid Progenitor Cell Differentiation
Immune System Process
Dendritic Cell Chemotaxis
Inflammatory Response To Antigenic Stimulus
Regulation Of Tolerance Induction
Regulation Of T Cell Mediated Immune Response To Tumor Cell
Glycogen Catabolic Process
DNA Metabolic Process
DNA Topological Change
DNA Repair
Base-excision Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Chromatin Organization
Chromatin Remodeling
Transcription By RNA Polymerase II
Autophagy
Chemotaxis
Inflammatory Response
Immune Response
DNA Damage Response
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Autophagy
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Myeloid Cell Differentiation
Lung Development
Neuron Projection Development
Heterochromatin Formation
Regulation Of Restriction Endodeoxyribonuclease Activity
DNA Geometric Change
Positive Regulation Of Mismatch Repair
Negative Regulation Of Type II Interferon Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
V(D)J Recombination
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 9 Signaling Pathway
T-helper 1 Cell Activation
Endothelial Cell Chemotaxis
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Cell Differentiation
Positive Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Glycogen Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Viral Entry Into Host Cell
Cell Development
Regulation Of Viral Process
Positive Chemotaxis
Regulation Of DNA Metabolic Process
Response To Glucocorticoid
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Positive Regulation Of Monocyte Chemotaxis
Positive Regulation Of Wound Healing
Neutrophil Clearance
Cellular Response To Interleukin-7
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Sprouting Angiogenesis
Regulation Of Hemopoiesis
Positive Regulation Of Myeloid Progenitor Cell Differentiation
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Apoptotic Cell Clearance
Regulation Of Nucleotide-excision Repair
Positive Regulation Of Dendritic Cell Differentiation
Pathways
Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
TGFBR3 PTM regulation
ER-Phagosome pathway
Apoptosis induced DNA fragmentation
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
TAK1-dependent IKK and NF-kappa-B activation
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Pyroptosis
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Drugs
Chloroquine
Ethyl pyruvate
Diseases
Alzheimer's disease (AD)
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Acne inversa; Hidradenitis supprativa
GWAS
Apolipoprotein B levels (
32203549
)
Glycated hemoglobin levels (
34059833
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Adult body size (
32376654
)
Apolipoprotein A1 levels (
32203549
)
Blood osmolality (transformed sodium) (
28360221
)
Carotid plaque burden (
28282560
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Hippocampal volume (
21116278
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Rapid response to perioperative phenylephrine (change in mean arterial pressure) (
33168928
)
Red blood cell count (
32888494
)
Triglyceride levels (
32203549
32154731
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Interacting Genes
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
132 interacting genes:
ACBD3
AGER
AGTRAP
AKIP1
AR
ATF7IP
ATOH1
C1QA
C1QBP
C3
CASP3
CCAR1
CCNDBP1
CDK1
CEBPA
CEBPB
CREBBP
CRMP1
CSNK1A1
CTCF
CTNNBL1
CUX1
DAG1
DLAT
DNAAF2
DNM2
DNMT1
DUX4
DYNC2I1
EIF1
ENAH
EP300
ERF
ERG28
FIP1L1
FOS
FOXA3
FOXC1
GOLM1
GTF2A1
HDAC1
HDLBP
HES1
HMGA1
HNRNPK
HNRNPU
HOXA10
HOXB1
HOXB3
HOXC6
HOXD10
HOXD11
HOXD3
HOXD8
HOXD9
HPF1
HR
HSPA5
IRF2
KRT7
LRIF1
MALAT1
MAP1B
MAPKAPK5
MECP2
MIEN1
MNAT1
MNT
MT2A
NCAN
NEUROD6
NEXN
NFKB1
NR3C1
PCOLCE
PGR
PLAT
PLG
POU5F1
PPP2R3A
PRKCA
PRKDC
PSEN1
PSMA7
PTPN2
PTPRZ1
RAD23B
RAG1
RASAL2
RASSF4
RB1
RBPJ
RELA
RFX1
RPL29
RPS12
RPS20
RSF1
SIX5
SOX18
SPIN1
SPINT1
SRSF3
STUB1
TAF1
TAF3
TBP
TERF2
TERF2IP
TFE3
TGIF1
TGM2
TGM3
TLE1
TLE2
TLE5
TLR2
TLR4
TP53
TP73
UBC
UBE2E3
UBE2I
UBXN1
UHRF2
UNC119
USP12
WNK4
YY1
ZFP36
ZNF24
ZNF428
Entrez ID
5663
3146
HPRD ID
00087
01228
Ensembl ID
ENSG00000080815
ENSG00000189403
Uniprot IDs
A0A024R6A3
A0A0S2Z4D2
P49768
B7Z965
P09429
Q5T7C4
PDB IDs
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
6LQG
6LR4
7C9I
7D8X
7Y5T
8IM7
8K8E
8KCO
8KCP
8KCS
8KCT
8KCU
8OQY
8OQZ
8X52
8X53
8X54
2LY4
2RTU
2YRQ
6CG0
6CIJ
6CIK
6CIL
6CIM
6OEM
6OEN
6OEO
8I9M
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Communication
Regulation Of Programmed Cell Death
Regulation Of Signaling
Regulation Of Apoptotic Process
Plasma Membrane
Positive Regulation Of Neuron Apoptotic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apoptotic Process
Regulation Of Protein Localization
Regulation Of Cell Development
Neuron Projection Development
Cytoplasm
Regulation Of Cell Differentiation
Programmed Cell Death
Regulation Of Developmental Process
Cell Death
Negative Regulation Of Developmental Process
Regulation Of Transport
Protein Processing
Cellular Response To Oxygen-containing Compound
Notch Signaling Pathway
Cytosol
Amyloid-beta Formation
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Signal Transduction
Regulation Of Biological Quality
Amyloid Precursor Protein Metabolic Process
Apoptotic Signaling Pathway
Negative Regulation Of Cell Development
Cellular Response To Indole-3-methanol
Cell Junction Organization
Regulation Of Establishment Of Protein Localization
Response To Indole-3-methanol
Cellular Localization
Modulation Of Chemical Synaptic Transmission
Cell-cell Junction
Regulation Of Synaptic Plasticity
Positive Regulation Of Proteolysis
Regulation Of Autophagy
Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Localization
Regulation Of Intracellular Signal Transduction
Protein Maturation
Regulation Of Developmental Growth
Amyloid Precursor Protein Catabolic Process
Chromatin
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Nucleus
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Transcription Regulator Complex
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Sequence-specific DNA Binding
Regionalization
Anterior/posterior Pattern Specification
Transcription Cis-regulatory Region Binding
Macromolecule Metabolic Process
Sequence-specific Double-stranded DNA Binding
Pattern Specification Process
Positive Regulation Of Developmental Process
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Chromatin Binding
Macromolecule Biosynthetic Process
Anatomical Structure Morphogenesis
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