PSEN1 and NOTCH1

  • Number of citations of the paper that reports this interaction (PMID 10206645)
  • 368
  • Data Source:
  • HPRD (in vivo)

PSEN1

NOTCH1

Gene Name presenilin 1 notch 1
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 91 interactors: ACTN1 AP1M2 APBA1 APH1A APH1B APOE APP BACE1 BCL2 BCL2L1 CASP1 CASP3 CASP4 CASP6 CASP7 CASP8 CDH1 CDK5 CFL1 CIB1 CTNNA1 CTNNB1 CTNND1 CTNND2 CYP2C18 CYP2C8 DLL1 DOCK3 DSP ECSIT EFHD1 EFNB2 ENSA EPB41L3 ERN1 ETFA FBXL12 FBXW7 FGF13 FLNA FLNB GAPDH GCDH GDI1 GFAP GSK3B HERPUD1 HMGB1 ICAM5 ITSN2 JUP KANK2 KCNIP3 KCNIP4 MAPT METTL2B MTCH1 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OXCT1 PDCD4 PIK3R1 PKP4 PRAM1 PRDX2 PRKACA PRKCZ PSENEN PSMA5 PSMB1 RAB11A RAB3A RAD23A RHEB RMDN3 RNF32 SCAF11 SCN1A ST13 STAMBPL1 TCF4 TCF7L2 TDP2 TUBA1B UBQLN1 UMPS YME1L1 56 interactors: ADAM17 AKT1 APBA1 BLOC1S1 CACNA1A CAMK4 CBL CNTN1 CTNNB1 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 FBXW7 FURIN GFI1B GSK3B ILK ITCH JAG1 JAG2 KAT2A KAT2B LCK LEF1 LFNG MAML1 MAML2 MAML3 MDM2 MEF2C MFNG NFKB1 NOV NUMB NUMBL PIK3CG POFUT1 PSEN1 PSEN2 RBP3 RBPJ REL RELA RUNX3 SMAD3 SNAI1 SNW1 USP12 WDR12 WWP1 XIAP XRCC6 YY1
Entrez ID 5663 4851
HPRD ID 00087 01827
Ensembl ID ENSG00000080815 ENSG00000148400
Uniprot IDs P49768 P46531
PDB IDs 2KR6 1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79
Enriched GO Terms of Interacting Partners?
Tagcloud ?
1795g  2125g  abeta37  abeta39  abeta40  advance  dementia  dementias  doi  e599k  ejhg  fus  g709s  genetics  genotyping  granulin  grn  harbored  hek293  journal  lewy  mapt  neuropathological  pd  publically  publication  shifted  tar  variants 
a23187  alpha1  antitrypsin  biologically  carboxyl  cleaved  convertase  convertases  decisions  dibasic  digestion  disagree  exists  extend  fate  furin  heterodimeric  invertebrates  ionophore  lovo  nearby  pdx  processed  processing  proteolytic  rqrr  takes  vertebrates 
Tagcloud (Difference) ?
1795g  2125g  abeta37  abeta39  abeta40  advance  dementia  dementias  doi  e599k  ejhg  fus  g709s  genetics  genotyping  granulin  grn  harbored  hek293  journal  lewy  mapt  neuropathological  pd  publically  publication  shifted  tar  variants 
a23187  alpha1  antitrypsin  biologically  carboxyl  cleaved  convertase  convertases  decisions  dibasic  digestion  disagree  exists  extend  fate  furin  heterodimeric  invertebrates  ionophore  lovo  nearby  pdx  processed  processing  proteolytic  rqrr  takes  vertebrates 
Tagcloud (Intersection) ?