PSEN1 and APH1B

  • Number of citations of the paper that reports this interaction (PMID 12471034)
  • 27
  • Data Source:
  • HPRD (in vivo)

PSEN1

APH1B

Gene Name presenilin 1 APH1B gamma secretase subunit
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 91 interactors: ACTN1 AP1M2 APBA1 APH1A APH1B APOE APP BACE1 BCL2 BCL2L1 CASP1 CASP3 CASP4 CASP6 CASP7 CASP8 CDH1 CDK5 CFL1 CIB1 CTNNA1 CTNNB1 CTNND1 CTNND2 CYP2C18 CYP2C8 DLL1 DOCK3 DSP ECSIT EFHD1 EFNB2 ENSA EPB41L3 ERN1 ETFA FBXL12 FBXW7 FGF13 FLNA FLNB GAPDH GCDH GDI1 GFAP GSK3B HERPUD1 HMGB1 ICAM5 ITSN2 JUP KANK2 KCNIP3 KCNIP4 MAPT METTL2B MTCH1 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OXCT1 PDCD4 PIK3R1 PKP4 PRAM1 PRDX2 PRKACA PRKCZ PSENEN PSMA5 PSMB1 RAB11A RAB3A RAD23A RHEB RMDN3 RNF32 SCAF11 SCN1A ST13 STAMBPL1 TCF4 TCF7L2 TDP2 TUBA1B UBQLN1 UMPS YME1L1 3 interactors: NCSTN PSEN1 PSEN2
Entrez ID 5663 83464
HPRD ID 00087 06361
Ensembl ID ENSG00000080815 ENSG00000138613
Uniprot IDs P49768 Q8WW43
PDB IDs 2KR6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
1795g  2125g  abeta37  abeta39  abeta40  advance  dementia  dementias  doi  e599k  ejhg  fus  g709s  genetics  genotyping  granulin  grn  harbored  hek293  journal  lewy  mapt  neuropathological  pd  publically  publication  shifted  tar  variants 
abeta  abeta38  abeta40  addressed  advance  affects  attributes  carboxypeptidase  catalytic  complexes  discriminate  dissociated  dissociation  endopeptidase  favoring  gamma  generation  intrinsic  produces  protease  psen2  qualitative  questions  retains  secretase  signature  valid  validation 
Tagcloud (Difference) ?
1795g  2125g  abeta37  abeta39  dementia  dementias  doi  e599k  ejhg  fus  g709s  genetics  genotyping  granulin  grn  harbored  hek293  journal  lewy  mapt  neuropathological  pd  publically  publication  shifted  tar  variants 
abeta  abeta38  addressed  affects  attributes  carboxypeptidase  catalytic  complexes  discriminate  dissociated  dissociation  endopeptidase  favoring  gamma  generation  intrinsic  produces  protease  psen2  qualitative  questions  retains  secretase  signature  valid  validation 
Tagcloud (Intersection) ?
abeta40  advance