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FBXL12 and SMAD1
Number of citations of the paper that reports this interaction (PMID
15761153
)
154
Data Source:
HPRD
(in vivo)
FBXL12
SMAD1
Gene Name
F-box and leucine-rich repeat protein 12
SMAD family member 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Cytoplasm
Intracellular
Nucleus
Nuclear Inner Membrane
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Integral Component Of Membrane
Protein Complex
Molecular Function
Protein Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
Sequence-specific DNA Binding Transcription Factor Activity
Receptor Signaling Protein Activity
Protein Binding
Protein Kinase Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Identical Protein Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
MAPK Cascade
Ureteric Bud Development
Mesodermal Cell Fate Commitment
Osteoblast Fate Commitment
Transcription, DNA-templated
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Gamete Generation
Negative Regulation Of Cell Proliferation
Embryonic Pattern Specification
Response To Organonitrogen Compound
Positive Regulation Of Gene Expression
Negative Regulation Of Muscle Cell Apoptotic Process
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Primary MiRNA Processing
Wound Healing
Response To Drug
Homeostatic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Dendrite Morphogenesis
Cartilage Development
Cardiac Muscle Cell Proliferation
Bone Development
Positive Regulation Of Cartilage Development
Cellular Response To BMP Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways
Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions
14 interactors:
A2M
APOE
CDC37
CDKN1C
DOCK8
ECSIT
FXYD3
LNX1
MAST1
PSEN1
PSEN2
RNF32
SMAD1
TGFBR1
138 interactors:
ACVR1
ACVRL1
AKR1B1
ANKRD27
AP2A2
APP
AR
ARHGEF6
ARL4D
BMPR1A
BTBD2
BTG2
CAMSAP1
CDK7
CDK9
CHMP3
COL4A1
DVL1
ECSIT
EIF2AK4
ELP3
EP300
ERBB2IP
EWSR1
FBXL12
FBXO30
FHL5
FOXG1
FRZB
GDF6
GLI3
GMEB1
GSC
GSK3B
HBP1
HIPK2
HOXA13
HOXA5
HOXC8
HOXD13
ICK
ING2
INPP4A
IRF2BP1
KAT2B
KMT2D
LEF1
LEMD3
MAPK1
MAST4
MBD1
MECOM
MED6
MEN1
MGA
MKL2
NAT9
NEDD4
NEDD9
NEUROG1
NKX3-2
NOTCH2
OAZ1
OAZ3
PAK1
PARD3B
PIAS1
PIAS4
PIGQ
PLEKHB1
PREB
PSMB4
PSMD1
PSMD11
PUM1
RAB2B
RAB30
RAB34
RAB38
RAB3B
RAB6B
RAC2
RAN
RAP2A
RASD2
RASL12
RFX1
RHEBL1
RHOG
RPS27A
SF3B1
SKI
SKIL
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMARCE1
SMURF1
SMURF2
SNIP1
SNRNP70
SOX5
SQSTM1
SS18L1
STARD13
STUB1
SUV39H1
TCF20
TGFBR1
TNNT1
TOB1
TRIP6
TTF1
TTF2
UBA52
UBC
UBE2Z
UBXN1
USP45
VEPH1
WDR77
XPC
XPO1
YAP1
YY1
ZBTB44
ZDHHC3
ZEB2
ZNF251
ZNF423
ZNF510
ZNF512B
ZNF521
ZNF76
ZNF8
ZSCAN4
Entrez ID
54850
4086
HPRD ID
12363
03356
Ensembl ID
ENSG00000127452
ENSG00000170365
Uniprot IDs
Q9NXK8
Q15797
PDB IDs
1KHU
2LAW
2LAX
2LAY
2LAZ
2LB0
2LB1
Enriched GO Terms of Interacting Partners
?
Regulation Of Catalytic Activity
Embryonic Morphogenesis
Intracellular Signal Transduction
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Thymus Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Generation Of Neurons
Amyloid Precursor Protein Catabolic Process
Anatomical Structure Morphogenesis
Neurogenesis
Regulation Of Protein Phosphorylation
Cell Fate Commitment
Neuron Differentiation
Embryo Development
Negative Regulation Of Protein Phosphorylation
Cell Activation
Response To Wounding
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorylation
Beta-amyloid Metabolic Process
Amyloid Precursor Protein Metabolic Process
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Phosphorylation
Membrane Protein Ectodomain Proteolysis
Notch Receptor Processing
Response To Cholesterol
Regulation Of Protein Binding
Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Nervous System Development
Regulation Of Cell Death
Regulation Of Synaptic Plasticity
Regulation Of Cell Morphogenesis
Pattern Specification Process
Regulation Of Cell Projection Organization
Neuron Development
Gland Development
Cell Differentiation
Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Metabolic Process
Response To Stress
Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Endothelial Cell Proliferation
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Gene Expression
Regulation Of Gene Expression
RNA Metabolic Process
Regulation Of Metabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cellular Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Transforming Growth Factor Beta
Cellular Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Biosynthetic Process
Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Signal Transduction
Regulation Of Signaling
Cellular Response To Growth Factor Stimulus
Pattern Specification Process
Signaling
Transcription From RNA Polymerase II Promoter
Tagcloud
?
balance
cav1
collagens
cytokeratin
dialytic
discontinuation
emt
eventually
fibrosis
fluids
fn
fsp
hyperactivation
invading
junction
laminin
matrices
mcs
mek
mesothelial
pd
peritoneal
peritoneum
proteomics
smad2
snail
stroma
thickness
zo
Tagcloud (Difference)
?
balance
cav1
collagens
cytokeratin
dialytic
discontinuation
emt
eventually
fibrosis
fluids
fn
fsp
hyperactivation
invading
junction
laminin
matrices
mcs
mek
mesothelial
pd
peritoneal
peritoneum
proteomics
smad2
snail
stroma
thickness
zo
Tagcloud (Intersection)
?