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FBXL12 and PSEN2
Number of citations of the paper that reports this interaction (PMID
21163940
)
13
Data Source:
BioGRID
(two hybrid)
FBXL12
PSEN2
Gene Name
F-box and leucine-rich repeat protein 12
presenilin 2
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Cytoplasm
Golgi Membrane
Kinetochore
Nuclear Inner Membrane
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Apical Plasma Membrane
Z Disc
Axon
Growth Cone
Neuromuscular Junction
Ciliary Rootlet
Ciliary Basal Body
Neuronal Cell Body
Dendritic Shaft
Protein Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Protein Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Response To Hypoxia
Cell Fate Specification
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Hair Follicle Development
Hematopoietic Progenitor Cell Differentiation
T Cell Activation Involved In Immune Response
Myeloid Leukocyte Differentiation
Membrane Protein Ectodomain Proteolysis
Calcium Ion Transport
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Notch Signaling Pathway
Notch Receptor Processing
Axon Guidance
Memory
Protein Transport
Protein Processing
Dorsal/ventral Neural Tube Patterning
Embryonic Limb Morphogenesis
Forebrain Development
Membrane Protein Intracellular Domain Proteolysis
Negative Regulation Of Protein Complex Assembly
Negative Regulation Of Protein Binding
Endoplasmic Reticulum Calcium Ion Homeostasis
Intracellular Signal Transduction
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Lung Alveolus Development
Thymus Development
Brain Morphogenesis
Beta-amyloid Metabolic Process
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Cardiac Muscle Contraction
Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Axon guidance
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by NOTCH2
EPH-ephrin mediated repulsion of cells
Signaling by NOTCH1
EPH-Ephrin signaling
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Signaling by NOTCH4
Regulated proteolysis of p75NTR
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
Signaling by NOTCH
p75 NTR receptor-mediated signalling
Signaling by ERBB4
NOTCH2 Activation and Transmission of Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Nuclear signaling by ERBB4
NRIF signals cell death from the nucleus
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH3
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions
14 interactors:
A2M
APOE
CDC37
CDKN1C
DOCK8
ECSIT
FXYD3
LNX1
MAST1
PSEN1
PSEN2
RNF32
SMAD1
TGFBR1
58 interactors:
AAMP
ACTG1
APH1A
APH1B
APP
BCL2L1
CAPN1
CASP1
CASP3
CASP6
CASP7
CASP8
CEP55
CFLAR
CHKA
CIB1
CSNK1A1
CSNK1D
CSNK2A1
CTNNB1
CTNND2
DNAJB1
DOCK3
ECD
EID1
ELAVL1
EVI5L
EXOC6
FBXL12
FHL2
FLNA
FLNB
GCDH
GFAP
HPS1
ICAM5
IFIT3
IFIT5
KCNIP3
KCNIP4
LIPF
MAST1
METTL2B
MGEA5
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
PDCD4
PSENEN
RAB11A
RHEB
RNF32
SPC24
SRI
UBQLN1
Entrez ID
54850
5664
HPRD ID
12363
02860
Ensembl ID
ENSG00000127452
ENSG00000143801
Uniprot IDs
Q9NXK8
P49810
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Catalytic Activity
Embryonic Morphogenesis
Intracellular Signal Transduction
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Thymus Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Generation Of Neurons
Amyloid Precursor Protein Catabolic Process
Anatomical Structure Morphogenesis
Neurogenesis
Regulation Of Protein Phosphorylation
Cell Fate Commitment
Neuron Differentiation
Embryo Development
Negative Regulation Of Protein Phosphorylation
Cell Activation
Response To Wounding
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorylation
Beta-amyloid Metabolic Process
Amyloid Precursor Protein Metabolic Process
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Phosphorylation
Membrane Protein Ectodomain Proteolysis
Notch Receptor Processing
Response To Cholesterol
Regulation Of Protein Binding
Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Nervous System Development
Regulation Of Cell Death
Regulation Of Synaptic Plasticity
Regulation Of Cell Morphogenesis
Pattern Specification Process
Regulation Of Cell Projection Organization
Neuron Development
Gland Development
Cell Differentiation
Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Metabolic Process
Response To Stress
Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Endothelial Cell Proliferation
Notch Receptor Processing
Cell Death
Death
Apoptotic Process
Programmed Cell Death
Notch Signaling Pathway
Regulation Of Apoptotic Process
Cell Differentiation
Regulation Of Cell Death
Cell Development
Positive Regulation Of Apoptotic Process
Cell Morphogenesis Involved In Differentiation
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Anatomical Structure Morphogenesis
Developmental Process
Signal Transduction
Protein Processing
Cellular Response To Stimulus
Signaling
Execution Phase Of Apoptosis
Response To Stimulus
Multicellular Organismal Development
System Development
Cell Communication
Anatomical Structure Development
Membrane Protein Intracellular Domain Proteolysis
Apoptotic Signaling Pathway
Cell Morphogenesis
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Neuron Differentiation
Regulation Of Cellular Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Positive Regulation Of Proteolysis
Intracellular Receptor Signaling Pathway
Response To External Stimulus
Cardiovascular System Development
Anatomical Structure Formation Involved In Morphogenesis
Angiogenesis
Positive Regulation Of Metabolic Process
Regulation Of Catalytic Activity
Negative Regulation Of Programmed Cell Death
Regulation Of Cellular Component Organization
Positive Regulation Of Peptidase Activity
Membrane Protein Proteolysis
Positive Regulation Of Catalytic Activity
Generation Of Neurons
Cell Cycle
Negative Regulation Of Cell Death
Tagcloud
?
abeta1
accelerated
amyloid
apoe4
bace1
becomes
casp3
deposits
event
hallmark
hyperphosphorylation
increasingly
later
losses
nonetheless
nonsynonymous
nontransgenic
oxys
picalm
posits
precede
proof
psen1
snps
sorl1
sporadic
triggers
turn
unlikely
Tagcloud (Difference)
?
abeta1
accelerated
amyloid
apoe4
bace1
becomes
casp3
deposits
event
hallmark
hyperphosphorylation
increasingly
later
losses
nonetheless
nonsynonymous
nontransgenic
oxys
picalm
posits
precede
proof
psen1
snps
sorl1
sporadic
triggers
turn
unlikely
Tagcloud (Intersection)
?