FBXL12 and CDKN1C

Number of citations of the paper that reports this interaction (PubMedID 18660753)
18

Data Source:
HPRD (in vivo)

		FBXL12	CDKN1C
Description		F-box and leucine rich repeat protein 12	cyclin dependent kinase inhibitor 1C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Protein Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein-containing Complex Binding Molecular Function Inhibitor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Kidney Development Placenta Development Regulation Of Exit From Mitosis Myeloid Cell Differentiation Adrenal Gland Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Multicellular Organism Growth Negative Regulation Of Phosphorylation Neuron Maturation Camera-type Eye Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Digestive System Development Uterus Development Embryonic Placenta Morphogenesis Genomic Imprinting Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases			Beckwith-Wiedemann syndrome Adrenal carcinoma
GWAS		Pursuit maintenance gain ( 29064472)	Birth weight ( 31043758) Calcium levels ( 20705733) Malaria ( 31844061) Type 1 diabetes ( 34012112)
Interacting Genes		19 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FBF1 FXYD3 GEMIN4 LNX1 MAST1 PSEN1 PSEN2 PSME3 RNF32 SMAD1 TGFBR1 UBE2D3	10 interacting genes: AKT1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2
Entrez ID		54850	1028
HPRD ID		12363	02913
Ensembl ID		ENSG00000127452	ENSG00000129757
Uniprot IDs		Q9NXK8	A0A2R8YFP9 P49918
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Regulation Of Amyloid Fibril Formation I-SMAD Binding Amyloid Precursor Protein Catabolic Process	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Response To Hormone Positive Regulation Of Deoxyribonuclease Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Oxygen-containing Compound Striated Muscle Cell Differentiation Transcription Regulator Complex Positive Regulation Of Cell Cycle Process Cellular Response To Ether Response To Peptide Hormone Kinase Binding Muscle Cell Differentiation Positive Regulation Of Cell Cycle Response To Oxygen Levels Cellular Response To Hormone Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Enzyme Binding Response To Ether Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Response To Insulin Positive Regulation Of Developmental Growth Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Neuron Maturation Cellular Response To Peptide Hormone Stimulus Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Starvation Myoblast Differentiation Regulation Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Catalytic Activity Response To Ketone Regulation Of Cell Cycle Chromatin Response To Starvation Macromolecule Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Growth Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Growth Male Germ Cell Nucleus Regulation Of Protein Modification Process Cellular Response To Nutrient Levels
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