Wiki-Pi
About
Search
People
Updates
Search
PSEN1 and PIK3R1
Number of citations of the paper that reports this interaction (PubMedID
15192701
)
43
Data Source:
HPRD
(in vitro)
PSEN1
PIK3R1
Description
presenilin 1
phosphoinositide-3-kinase regulatory subunit 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Kinetochore
Nucleus
Nuclear Outer Membrane
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosomal Membrane
Endosome
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Cell Cortex
Synaptic Vesicle
Cell Surface
Membrane
Aggresome
Cell Junction
Axon
Dendrite
Growth Cone
Cytoplasmic Vesicle
Neuromuscular Junction
Early Endosome Membrane
Nuclear Membrane
Protein-containing Complex
Ciliary Rootlet
Azurophil Granule Membrane
Sarcolemma
Presynaptic Membrane
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Synapse
Gamma-secretase Complex
Synaptic Membrane
Postsynapse
Glutamatergic Synapse
Nucleus
Cytoplasm
Cis-Golgi Network
Cytosol
Plasma Membrane
Cell-cell Junction
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Membrane
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum Membrane
Molecular Function
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Calcium Channel Activity
Protein Binding
Beta-catenin Binding
Peptidase Activity
Hydrolase Activity
PDZ Domain Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Cadherin Binding
ATPase Binding
Growth Factor Receptor Binding
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
GTPase Activator Activity
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Kinase Regulator Activity
Kinase Activator Activity
Protein Phosphatase Binding
Phosphatidylinositol 3-kinase Regulator Activity
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
ErbB-3 Class Receptor Binding
Phosphatidylinositol 3-kinase Binding
Insulin Binding
Insulin Receptor Substrate Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Phosphatidylinositol Kinase Activity
Enzyme-substrate Adaptor Activity
Phosphatidylinositol 3-kinase Activator Activity
Biological Process
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Development
Cell Fate Specification
Somitogenesis
Neuron Migration
Positive Regulation Of Receptor Recycling
Heart Looping
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Hematopoietic Progenitor Cell Differentiation
Astrocyte Activation Involved In Immune Response
T Cell Activation Involved In Immune Response
Myeloid Leukocyte Differentiation
Neural Retina Development
Protein Glycosylation
Proteolysis
Membrane Protein Ectodomain Proteolysis
Mitochondrial Transport
Intracellular Calcium Ion Homeostasis
Autophagy
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Cell Adhesion
Notch Signaling Pathway
Notch Receptor Processing
Brain Development
Heart Development
Learning Or Memory
Memory
Post-embryonic Development
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Neuron Projection Development
Protein Transport
Choline Transport
Synaptic Vesicle Targeting
Protein Processing
Cerebellum Development
Cerebral Cortex Cell Migration
Cajal-Retzius Cell Differentiation
Dorsal/ventral Neural Tube Patterning
Cerebral Cortex Development
Neurogenesis
Neuron Differentiation
Embryonic Limb Morphogenesis
Forebrain Development
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Tumor Necrosis Factor Production
Amyloid-beta Formation
Segmentation
Intracellular Signal Transduction
Locomotion
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Skin Morphogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Astrocyte Activation
Regulation Of Synaptic Plasticity
Thymus Development
Neuron Development
Skeletal System Morphogenesis
Brain Morphogenesis
Amyloid-beta Metabolic Process
Epithelial Cell Proliferation
Negative Regulation Of Axonogenesis
Synapse Organization
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Sequestering Of Calcium Ion
Neuron Apoptotic Process
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Protein Maturation
Regulation Of Synaptic Transmission, Glutamatergic
Calcium Ion Homeostasis
Regulation Of Resting Membrane Potential
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Dendritic Spine Development
Neuron Cellular Homeostasis
Calcium Ion Transmembrane Transport
Apoptotic Signaling Pathway
Cell-cell Adhesion
Regulation Of Synaptic Vesicle Cycle
L-glutamate Import Across Plasma Membrane
Regulation Of Postsynapse Organization
Protein Catabolic Process At Postsynapse
Cellular Response To Amyloid-beta
Negative Regulation Of Core Promoter Binding
Positive Regulation Of Amyloid Fibril Formation
Neuron Projection Maintenance
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Intracellular Glucose Homeostasis
Negative Regulation Of Cell-matrix Adhesion
Positive Regulation Of Leukocyte Migration
Transcription By RNA Polymerase II
Protein Import Into Nucleus
Immune Response
Negative Regulation Of Cell Adhesion
Signal Transduction
Insulin Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Lamellipodium Assembly
Protein Transport
Cytokine-mediated Signaling Pathway
B Cell Differentiation
T Cell Differentiation
Osteoclast Differentiation
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Positive Regulation Of RNA Splicing
Regulation Of Toll-like Receptor 4 Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
Interleukin-18-mediated Signaling Pathway
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of D-glucose Import
Phosphatidylinositol Phosphate Biosynthetic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Positive Regulation Of Filopodium Assembly
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
T Follicular Helper Cell Differentiation
Myeloid Leukocyte Migration
Positive Regulation Of Focal Adhesion Disassembly
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Protein Localization To Plasma Membrane
Pathways
Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
TGFBR3 PTM regulation
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
GP1b-IX-V activation signalling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
RHOF GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Activated NTRK3 signals through PI3K
FLT3 Signaling
FLT3 Signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF1 (M-CSF) in myeloid cells
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by FLT3 fusion proteins
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by ALK fusions and activated point mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Signaling by LTK in cancer
Signaling by LTK
Co-stimulation by ICOS
Drugs
SF1126
Enzastaurin
Wortmannin
Diseases
Alzheimer's disease (AD)
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Acne inversa; Hidradenitis supprativa
GWAS
Apolipoprotein B levels (
32203549
)
Glycated hemoglobin levels (
34059833
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Alzheimer's disease biomarkers (
23419831
)
Anthropometric traits (multi-trait analysis) (
30166351
)
Appendicular lean mass (
33097823
)
Basal cell carcinoma (
33549134
)
Birth weight (
31043758
)
Body fat percentage and HDL-C (pairwise) (
33619380
)
Bone mineral density (hip) (
26911590
)
Corneal astigmatism (
30306274
)
Crohn's disease (
32581322
)
Estimated glomerular filtration rate (
30604766
31152163
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
HDL cholesterol levels (
32203549
)
Height (
31562340
)
Hip minimal joint space width (
27701424
)
Intelligence (MTAG) (
29326435
)
Leg fat mass (lean adjusted) (
32719433
)
Leg fat mass and leg lean mass (pleiotropy) (
32719433
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Menarche (age at onset) (
23599027
)
Offspring birth weight (
31043758
)
Red cell distribution width (
32888494
27863252
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
32203549
29083408
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
180 interacting genes:
ABL1
ADAM12
ADAMTS2
AGAP2
AKT1
ALK
ANK3
APPL1
AR
ARAF
ARHGAP1
ARHGAP17
ARHGAP32
AXL
BCAR1
BLK
BRCA1
CBL
CBLB
CCL14
CD19
CD22
CD28
CD2AP
CD3E
CD4
CD40
CD5
CD7
CDC42
CDH2
CHRNA7
CIP2A
CLNK
CRK
CRKL
CSF1R
CSF2RA
CTLA4
CTNNB1
CXCL2
CYP4A11
DLX2
DNM1
DOK1
EGF
EGFR
ENKUR
EPHA2
EPOR
ERAS
ERBB2
ERBB3
ERBB4
ESR1
EZR
FASLG
FBXO21
FCGR2A
FER
FES
FGFR1
FLT1
FYN
GAB1
GAB2
GAB3
GHR
GP1BA
GRB2
GSPT1
GTF2H1
HCK
HCST
HGS
HOXA1
HRAS
HTT
IFNAR1
IGF1R
IKZF3
IL13
IL1R1
IL1RAP
IL2RB
IL7R
INPP4A
INSR
IRS1
IRS2
IRS4
ITSN1
JAK1
JAK2
JAK3
KBTBD2
KHDRBS1
KIT
LAT
LCK
LNX2
LRRK2
MAPK8
MAPT
MET
MME
MST1R
MYO16
NFKBIA
NLRP6
NTRK1
NTRK2
NUP85
NYAP1
NYAP2
PASK
PDE4D
PDGFB
PDGFRA
PDGFRB
PECAM1
PFN1
PIK3AP1
PIK3CA
PIK3CB
PIK3CD
PPM1A
PRMT8
PROM1
PSEN1
PSMB5
PTEN
PTK2
PTK2B
PTPN11
PTPN6
RAC1
RASA1
RASD2
RB1
RET
RRAS2
SH3KBP1
SHB
SHC1
SLC9A2
SOCS1
SOCS6
SOCS7
SQSTM1
SRC
SSTR2
STAT3
SYK
SYN1
TEC
TEK
TGFBR1
TGFBR2
TIE1
TLR2
TNK2
TNS4
TOM1L1
TRAT1
TRIM25
TSHR
TTR
TUB
TUBA1B
TUBG1
TXK
TYK2
TYRO3
VAV1
VAV3
WAS
WASF3
WBP11
YWHAG
Entrez ID
5663
5295
HPRD ID
00087
01381
Ensembl ID
ENSG00000080815
ENSG00000145675
Uniprot IDs
A0A024R6A3
A0A0S2Z4D2
P49768
A0A2X0SFG1
P27986
PDB IDs
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
6LQG
6LR4
7C9I
7D8X
7Y5T
8IM7
8K8E
8KCO
8KCP
8KCS
8KCT
8KCU
8OQY
8OQZ
8X52
8X53
8X54
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
2IUG
2IUH
2IUI
2RD0
2V1Y
3HHM
3HIZ
3I5R
3I5S
4A55
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4WAF
4YKN
4ZOP
5AUL
5FI4
5GJI
5ITD
5M6U
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBT
5UK8
5UKJ
5UL1
5VLR
5XGH
5XGI
5XGJ
6NCT
6PYR
6PYU
7CIO
7LM2
7LQ1
7MYN
7MYO
7PG5
7PG6
7RNS
7TZ7
8AM0
8DCP
8DCX
8DD4
8DD8
8GUB
8H36
8H37
8ILR
8ILS
8ILV
8SBC
8SBJ
8TDU
8TGD
8TS7
8TS8
8TS9
8TSA
8TSB
8TSC
8TSD
8TU6
8V8H
8V8I
8V8J
8V8U
8V8V
8W9A
8W9B
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Communication
Regulation Of Programmed Cell Death
Regulation Of Signaling
Regulation Of Apoptotic Process
Plasma Membrane
Positive Regulation Of Neuron Apoptotic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apoptotic Process
Regulation Of Protein Localization
Regulation Of Cell Development
Neuron Projection Development
Cytoplasm
Regulation Of Cell Differentiation
Programmed Cell Death
Regulation Of Developmental Process
Cell Death
Negative Regulation Of Developmental Process
Regulation Of Transport
Protein Processing
Cellular Response To Oxygen-containing Compound
Notch Signaling Pathway
Cytosol
Amyloid-beta Formation
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Signal Transduction
Regulation Of Biological Quality
Amyloid Precursor Protein Metabolic Process
Apoptotic Signaling Pathway
Negative Regulation Of Cell Development
Cellular Response To Indole-3-methanol
Cell Junction Organization
Regulation Of Establishment Of Protein Localization
Response To Indole-3-methanol
Cellular Localization
Modulation Of Chemical Synaptic Transmission
Cell-cell Junction
Regulation Of Synaptic Plasticity
Positive Regulation Of Proteolysis
Regulation Of Autophagy
Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Localization
Regulation Of Intracellular Signal Transduction
Protein Maturation
Regulation Of Developmental Growth
Amyloid Precursor Protein Catabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Plasma Membrane
Regulation Of Signal Transduction
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Immune System Process
Protein Kinase Activity
Regulation Of Immune Response
Kinase Activity
Positive Regulation Of Multicellular Organismal Process
Transmembrane Receptor Protein Tyrosine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Phosphorylation
Immune Response-regulating Signaling Pathway
Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Protein Phosphorylation
Receptor Complex
Positive Regulation Of MAPK Cascade
Intracellular Signaling Cassette
Regulation Of Cell Population Proliferation
Regulation Of Cell Activation
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Immune Response
Cell Migration
Cytokine-mediated Signaling Pathway
Protein Autophosphorylation
Regulation Of Developmental Process
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Migration
Activation Of Immune Response
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?