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PSEN1 and BACE1
Number of citations of the paper that reports this interaction (PubMedID
12901838
)
0
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
PSEN1
BACE1
Description
presenilin 1
beta-secretase 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Kinetochore
Nucleus
Nuclear Outer Membrane
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosomal Membrane
Endosome
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Cell Cortex
Synaptic Vesicle
Cell Surface
Membrane
Aggresome
Cell Junction
Axon
Dendrite
Growth Cone
Cytoplasmic Vesicle
Neuromuscular Junction
Early Endosome Membrane
Nuclear Membrane
Protein-containing Complex
Ciliary Rootlet
Azurophil Granule Membrane
Sarcolemma
Presynaptic Membrane
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Synapse
Gamma-secretase Complex
Synaptic Membrane
Postsynapse
Glutamatergic Synapse
Lysosome
Endosome
Early Endosome
Late Endosome
Multivesicular Body
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Synaptic Vesicle
Cell Surface
Endosome Membrane
Membrane
Axon
Dendrite
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Cell Projection
Neuronal Cell Body
Membrane Raft
Recycling Endosome
Golgi-associated Vesicle Lumen
Hippocampal Mossy Fiber To CA3 Synapse
Presynapse
Molecular Function
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Calcium Channel Activity
Protein Binding
Beta-catenin Binding
Peptidase Activity
Hydrolase Activity
PDZ Domain Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Cadherin Binding
ATPase Binding
Growth Factor Receptor Binding
Amyloid-beta Binding
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Beta-aspartyl-peptidase Activity
Hydrolase Activity
Enzyme Binding
Protein Serine/threonine Kinase Binding
Biological Process
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Development
Cell Fate Specification
Somitogenesis
Neuron Migration
Positive Regulation Of Receptor Recycling
Heart Looping
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Hematopoietic Progenitor Cell Differentiation
Astrocyte Activation Involved In Immune Response
T Cell Activation Involved In Immune Response
Myeloid Leukocyte Differentiation
Neural Retina Development
Protein Glycosylation
Proteolysis
Membrane Protein Ectodomain Proteolysis
Mitochondrial Transport
Intracellular Calcium Ion Homeostasis
Autophagy
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Cell Adhesion
Notch Signaling Pathway
Notch Receptor Processing
Brain Development
Heart Development
Learning Or Memory
Memory
Post-embryonic Development
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Neuron Projection Development
Protein Transport
Choline Transport
Synaptic Vesicle Targeting
Protein Processing
Cerebellum Development
Cerebral Cortex Cell Migration
Cajal-Retzius Cell Differentiation
Dorsal/ventral Neural Tube Patterning
Cerebral Cortex Development
Neurogenesis
Neuron Differentiation
Embryonic Limb Morphogenesis
Forebrain Development
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Tumor Necrosis Factor Production
Amyloid-beta Formation
Segmentation
Intracellular Signal Transduction
Locomotion
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Skin Morphogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Astrocyte Activation
Regulation Of Synaptic Plasticity
Thymus Development
Neuron Development
Skeletal System Morphogenesis
Brain Morphogenesis
Amyloid-beta Metabolic Process
Epithelial Cell Proliferation
Negative Regulation Of Axonogenesis
Synapse Organization
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Sequestering Of Calcium Ion
Neuron Apoptotic Process
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Protein Maturation
Regulation Of Synaptic Transmission, Glutamatergic
Calcium Ion Homeostasis
Regulation Of Resting Membrane Potential
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Dendritic Spine Development
Neuron Cellular Homeostasis
Calcium Ion Transmembrane Transport
Apoptotic Signaling Pathway
Cell-cell Adhesion
Regulation Of Synaptic Vesicle Cycle
L-glutamate Import Across Plasma Membrane
Regulation Of Postsynapse Organization
Protein Catabolic Process At Postsynapse
Cellular Response To Amyloid-beta
Negative Regulation Of Core Promoter Binding
Positive Regulation Of Amyloid Fibril Formation
Neuron Projection Maintenance
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Proteolysis
Membrane Protein Ectodomain Proteolysis
Response To Lead Ion
Protein Processing
Amyloid-beta Formation
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Amyloid-beta Metabolic Process
Modulation Of Chemical Synaptic Transmission
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Prepulse Inhibition
Cellular Response To Copper Ion
Cellular Response To Manganese Ion
Presynaptic Modulation Of Chemical Synaptic Transmission
Signaling Receptor Ligand Precursor Processing
Cellular Response To Amyloid-beta
Amyloid Fibril Formation
Pathways
Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
TGFBR3 PTM regulation
Amyloid fiber formation
Drugs
MMI-175
CTS-21166
N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE
N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide
4-(4-FLUOROBENZYL)PIPERIDINE
N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide
6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE
6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE
N~3~-BENZYLPYRIDINE-2,3-DIAMINE
N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE
N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE
4-(2-aminoethyl)-2-cyclohexylphenol
4-(2-aminoethyl)-2-ethylphenol
4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine
(6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one
(2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol
N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide
N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
(2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
(2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
(6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE
N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE
3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
Verubecestat
Diseases
Alzheimer's disease (AD)
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Acne inversa; Hidradenitis supprativa
GWAS
Apolipoprotein B levels (
32203549
)
Glycated hemoglobin levels (
34059833
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Cardiovascular disease risk factors (
21779381
)
Diffusing capacity of carbon monoxide (
30694715
)
Mean platelet volume (
32888494
)
Interacting Genes
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
25 interacting genes:
ADRB2
APP
ATP1B1
BRI3
CMPK1
CSNK1D
FBXO2
FURIN
GGA1
GGA2
ITM2C
KHSRP
LRP1
MMP2
NCSTN
PCSK9
PDIA3
PLSCR1
PSAP
PSEN1
RANBP9
SELPLG
STUB1
TNIP2
USP8
Entrez ID
5663
23621
HPRD ID
00087
07255
Ensembl ID
ENSG00000080815
ENSG00000186318
Uniprot IDs
A0A024R6A3
A0A0S2Z4D2
P49768
A0A7P0TAB4
B7Z3K2
B7Z3Z4
P56817
PDB IDs
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
6LQG
6LR4
7C9I
7D8X
7Y5T
8IM7
8K8E
8KCO
8KCP
8KCS
8KCT
8KCU
8OQY
8OQZ
8X52
8X53
8X54
1FKN
1M4H
1PY1
1SGZ
1TQF
1UJJ
1UJK
1W50
1W51
1XN2
1XN3
1XS7
1YM2
1YM4
2B8L
2B8V
2F3E
2F3F
2FDP
2G94
2HIZ
2HM1
2IQG
2IRZ
2IS0
2NTR
2OAH
2OF0
2OHK
2OHL
2OHM
2OHN
2OHP
2OHQ
2OHR
2OHS
2OHT
2OHU
2P4J
2P83
2P8H
2PH6
2PH8
2Q11
2Q15
2QK5
2QMD
2QMF
2QMG
2QP8
2QU2
2QU3
2QZK
2QZL
2VA5
2VA6
2VA7
2VIE
2VIJ
2VIY
2VIZ
2VJ6
2VJ7
2VJ9
2VKM
2VNM
2VNN
2WEZ
2WF0
2WF1
2WF2
2WF3
2WF4
2WJO
2XFI
2XFJ
2XFK
2ZDZ
2ZE1
2ZHR
2ZHS
2ZHT
2ZHU
2ZHV
2ZJH
2ZJI
2ZJJ
2ZJK
2ZJL
2ZJM
2ZJN
3BRA
3BUF
3BUG
3BUH
3CIB
3CIC
3CID
3CKP
3CKR
3DM6
3DUY
3DV1
3DV5
3EXO
3FKT
3H0B
3HVG
3HW1
3I25
3IGB
3IN3
3IN4
3IND
3INE
3INF
3INH
3IVH
3IVI
3IXJ
3IXK
3K5C
3K5D
3K5F
3K5G
3KMX
3KMY
3KN0
3KYR
3L38
3L3A
3L58
3L59
3L5B
3L5C
3L5D
3L5E
3L5F
3LHG
3LNK
3LPI
3LPJ
3LPK
3MSJ
3MSK
3MSL
3N4L
3NSH
3OHF
3OHH
3OOZ
3PI5
3QBH
3QI1
3R1G
3R2F
3RSV
3RSX
3RTH
3RTM
3RTN
3RU1
3RVI
3S2O
3S7L
3S7M
3SKF
3SKG
3TPJ
3TPL
3TPP
3TPR
3U6A
3UDH
3UDJ
3UDK
3UDM
3UDN
3UDP
3UDQ
3UDR
3UDY
3UFL
3UQP
3UQR
3UQU
3UQW
3UQX
3VEU
3VF3
3VG1
3VV6
3VV7
3VV8
3WB4
3WB5
3ZMG
3ZOV
4ACU
4ACX
4AZY
4B00
4B05
4B0Q
4B1C
4B1D
4B1E
4B70
4B72
4B77
4B78
4BEK
4BFD
4D83
4D85
4D88
4D89
4D8C
4DH6
4DI2
4DJU
4DJV
4DJW
4DJX
4DJY
4DPF
4DPI
4DUS
4DV9
4DVF
4EWO
4EXG
4FCO
4FGX
4FM7
4FM8
4FRI
4FRJ
4FRK
4FRS
4FS4
4FSE
4FSL
4GID
4GMI
4H1E
4H3F
4H3G
4H3I
4H3J
4HA5
4HZT
4I0D
4I0E
4I0F
4I0G
4I0H
4I0I
4I0J
4I0Z
4I10
4I11
4I12
4I1C
4IVS
4IVT
4J0P
4J0T
4J0V
4J0Y
4J0Z
4J17
4J1C
4J1E
4J1F
4J1H
4J1I
4J1K
4JOO
4JP9
4JPC
4JPE
4K8S
4K9H
4KE0
4KE1
4L7G
4L7H
4L7J
4LC7
4LXA
4LXK
4LXM
4N00
4PZW
4PZX
4R5N
4R8Y
4R91
4R92
4R93
4R95
4RCD
4RCE
4RCF
4RRN
4RRO
4RRS
4TRW
4TRY
4TRZ
4WTU
4WY1
4WY6
4X2L
4X7I
4XKX
4XXS
4YBI
4ZPE
4ZPF
4ZPG
4ZSM
4ZSP
4ZSQ
4ZSR
5CLM
5DQC
5ENK
5ENM
5EZX
5EZZ
5F00
5F01
5HD0
5HDU
5HDV
5HDX
5HDZ
5HE4
5HE5
5HE7
5HTZ
5HU0
5HU1
5I3V
5I3W
5I3X
5I3Y
5IE1
5KQF
5KR8
5MBW
5MCO
5MCQ
5MXD
5QCO
5QCP
5QCQ
5QCR
5QCS
5QCT
5QCU
5QCV
5QCW
5QCX
5QCY
5QCZ
5QD0
5QD1
5QD2
5QD3
5QD4
5QD5
5QD6
5QD7
5QD8
5QD9
5QDA
5QDB
5QDC
5QDD
5T1U
5T1W
5TOL
5UYU
5V0N
5YGX
5YGY
6BFD
6BFE
6BFW
6BFX
6C2I
6DHC
6DMI
6E3Z
6EJ2
6EJ3
6EQM
6FGY
6JSE
6JSF
6JSG
6JSN
6JT3
6JT4
6NV7
6NV9
6NW3
6OD6
6PZ4
6UVP
6UVV
6UVY
6UWP
6UWV
6WNY
7B1E
7B1P
7B1Q
7D2V
7D2X
7D36
7D5A
7DCZ
7F1D
7MYI
7MYR
7MYU
7N66
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Communication
Regulation Of Programmed Cell Death
Regulation Of Signaling
Regulation Of Apoptotic Process
Plasma Membrane
Positive Regulation Of Neuron Apoptotic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apoptotic Process
Regulation Of Protein Localization
Regulation Of Cell Development
Neuron Projection Development
Cytoplasm
Regulation Of Cell Differentiation
Programmed Cell Death
Regulation Of Developmental Process
Cell Death
Negative Regulation Of Developmental Process
Regulation Of Transport
Protein Processing
Cellular Response To Oxygen-containing Compound
Notch Signaling Pathway
Cytosol
Amyloid-beta Formation
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Signal Transduction
Regulation Of Biological Quality
Amyloid Precursor Protein Metabolic Process
Apoptotic Signaling Pathway
Negative Regulation Of Cell Development
Cellular Response To Indole-3-methanol
Cell Junction Organization
Regulation Of Establishment Of Protein Localization
Response To Indole-3-methanol
Cellular Localization
Modulation Of Chemical Synaptic Transmission
Cell-cell Junction
Regulation Of Synaptic Plasticity
Positive Regulation Of Proteolysis
Regulation Of Autophagy
Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Localization
Regulation Of Intracellular Signal Transduction
Protein Maturation
Regulation Of Developmental Growth
Amyloid Precursor Protein Catabolic Process
Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Catabolic Process
Positive Regulation Of Protein Metabolic Process
Early Endosome
Astrocyte Activation Involved In Immune Response
Response To Amyloid-beta
Positive Regulation Of Amyloid Fibril Formation
Growth Factor Receptor Binding
Regulation Of Protein Metabolic Process
Golgi Apparatus
Regulation Of Signaling
Lysosomal Membrane
Cellular Response To Amyloid-beta
Azurophil Granule Membrane
Apolipoprotein Binding
Regulation Of Cell Communication
Regulation Of Amyloid Fibril Formation
Astrocyte Activation
Endosome Membrane
Positive Regulation Of Macromolecule Metabolic Process
Lysosome
Amyloid-beta Metabolic Process
Amyloid-beta Binding
Endosome
Endopeptidase Activity
Regulation Of Primary Metabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Programmed Cell Death
Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Positive Regulation Of Metabolic Process
Plasma Membrane
Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Intracellular Transport
Lysosomal Transport
Regulation Of Metabolic Process
Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Peptidase Activity
Gamma-secretase Complex
Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Signaling Pathway
Glutamate Receptor Signaling Pathway
Heparan Sulfate Binding
Positive Regulation Of Apoptotic Signaling Pathway
Modulation Of Chemical Synaptic Transmission
Notch Receptor Processing
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
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