FBXL12 and CDC37

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		FBXL12	CDC37
Gene Name		F-box and leucine-rich repeat protein 12	cell division cycle 37
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm	Cytoplasm Cytosol Ruffle Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding Kinase Binding Heat Shock Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Kinase B Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways			Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		14 interactors: A2M APOE CDC37 CDKN1C DOCK8 ECSIT FXYD3 LNX1 MAST1 PSEN1 PSEN2 RNF32 SMAD1 TGFBR1	72 interactors: A2M APOE APP AR BTBD10 C19orf44 CC2D1A CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CYP2C9 DCTN1 DEAF1 ECSIT EIF2AK1 ELAVL3 EXOSC1 FBXL12 FBXW4 GCDH GCH1 HSP90AA1 IFIT3 IFIT5 IKBKB IKBKE IKBKG IMMT LONP1 LOXL4 LUC7L2 MAP3K14 MAP3K3 MGEA5 MTOR MZT2B NCOA5 NOS3 NR2C2 PPHLN1 PRAM1 PRDX2 PRMT1 PSME1 RAD23A RNF32 RPS15A SAFB SNX5 SPTBN4 SQSTM1 SRC STAMBPL1 STIP1 STK11 TBK1 UBE2I ZNF205 ZNF235 ZNF266 ZNF667
Entrez ID		54850	11140
HPRD ID		12363	05456
Ensembl ID		ENSG00000127452	ENSG00000105401
Uniprot IDs		Q9NXK8	Q16543
PDB IDs			1US7 2K5B 2W0G
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Embryonic Morphogenesis Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Thymus Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Generation Of Neurons Amyloid Precursor Protein Catabolic Process Anatomical Structure Morphogenesis Neurogenesis Regulation Of Protein Phosphorylation Cell Fate Commitment Neuron Differentiation Embryo Development Negative Regulation Of Protein Phosphorylation Cell Activation Response To Wounding Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Phosphorylation Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Response To Cholesterol Regulation Of Protein Binding Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Nervous System Development Regulation Of Cell Death Regulation Of Synaptic Plasticity Regulation Of Cell Morphogenesis Pattern Specification Process Regulation Of Cell Projection Organization Neuron Development Gland Development Cell Differentiation Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Metabolic Process Response To Stress Dorsal/ventral Neural Tube Patterning Negative Regulation Of Endothelial Cell Proliferation	Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Cellular Metabolic Process Response To External Stimulus Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Kinase Activity I-kappaB Kinase/NF-kappaB Signaling Response To Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mitotic Cell Cycle Phase Transition Response To Virus Cell Cycle Phase Transition Catabolic Process Regulation Of Catalytic Activity Intracellular Receptor Signaling Pathway Cell Cycle Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cell Cycle Process Regulation Of Signal Transduction Protein Catabolic Process Mitotic Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Signaling Toll-like Receptor 3 Signaling Pathway Regulation Of Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus
Tagcloud ?			base chick clusters conforms consensus copies emphasize exons finger flanking gctat ggg glycosaminoglycans homeodomain hsp90 introns kilobases mzf1 pair presumptive promotion reorganization repetitive s8 sizes sp1 stabilization striking tatgggga
Tagcloud (Difference) ?			base chick clusters conforms consensus copies emphasize exons finger flanking gctat ggg glycosaminoglycans homeodomain hsp90 introns kilobases mzf1 pair presumptive promotion reorganization repetitive s8 sizes sp1 stabilization striking tatgggga
Tagcloud (Intersection) ?