PSEN1 and RAB3A

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		PSEN1	RAB3A
Gene Name		presenilin 1	RAB3A, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Kinetochore Nuclear Outer Membrane Mitochondrion Mitochondrial Inner Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Centrosome Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Z Disc Axon Growth Cone Cytoplasmic Vesicle Neuromuscular Junction Nuclear Membrane Ciliary Rootlet Neuronal Cell Body Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Gamma-secretase Complex	Acrosomal Vesicle Endosome Cytosol Plasma Membrane Synaptic Vesicle Axon Secretory Granule Membrane Vesicle Terminal Bouton Protein Complex Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Calcium Channel Activity Protein Binding Beta-catenin Binding PDZ Domain Binding Cadherin Binding	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding Protein C-terminus Binding GDP Binding Myosin V Binding GTPase Binding ATPase Binding
	Biological Process	Autophagic Vacuole Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKK Activity Blood Vessel Development Cell Fate Specification Somitogenesis Neuron Migration Positive Regulation Of Receptor Recycling Heart Looping Hematopoietic Progenitor Cell Differentiation T Cell Activation Involved In Immune Response Protein Glycosylation Membrane Protein Ectodomain Proteolysis Mitochondrial Transport Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Notch Signaling Pathway Notch Receptor Processing Memory Post-embryonic Development Protein Transport L-glutamate Transport Choline Transport Synaptic Vesicle Targeting Single Organismal Cell-cell Adhesion Protein Processing Cerebral Cortex Cell Migration Cajal-Retzius Cell Differentiation Dorsal/ventral Neural Tube Patterning Extracellular Matrix Disassembly Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Beta-amyloid Formation Intracellular Signal Transduction Regulation Of Phosphorylation Amyloid Precursor Protein Catabolic Process Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Protein Binding Positive Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Skin Morphogenesis Regulation Of Synaptic Plasticity Thymus Development Neuron Development Skeletal System Morphogenesis Brain Morphogenesis Beta-amyloid Metabolic Process Epithelial Cell Proliferation Negative Regulation Of Axonogenesis Positive Regulation Of Coagulation T Cell Receptor Signaling Pathway Neuron Apoptotic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Regulation Of Resting Membrane Potential Calcium Ion Transmembrane Transport Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway	Respiratory System Process Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Mitochondrion Organization Synaptic Transmission Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axonogenesis Protein Secretion Post-embryonic Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Lung Development Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Rab Protein Signal Transduction Positive Regulation Of ATPase Activity Synaptic Vesicle Recycling Constitutive Secretory Pathway Positive Regulation Of Exocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure Sensory Perception Of Touch Response To Electrical Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Regulated Secretory Pathway
Pathways		Degradation of the extracellular matrix	Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		91 interactors: ACTN1 AP1M2 APBA1 APH1A APH1B APOE APP BACE1 BCL2 BCL2L1 CASP1 CASP3 CASP4 CASP6 CASP7 CASP8 CDH1 CDK5 CFL1 CIB1 CTNNA1 CTNNB1 CTNND1 CTNND2 CYP2C18 CYP2C8 DLL1 DOCK3 DSP ECSIT EFHD1 EFNB2 ENSA EPB41L3 ERN1 ETFA FBXL12 FBXW7 FGF13 FLNA FLNB GAPDH GCDH GDI1 GFAP GSK3B HERPUD1 HMGB1 ICAM5 ITSN2 JUP KANK2 KCNIP3 KCNIP4 MAPT METTL2B MTCH1 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OXCT1 PDCD4 PIK3R1 PKP4 PRAM1 PRDX2 PRKACA PRKCZ PSENEN PSMA5 PSMB1 RAB11A RAB3A RAD23A RHEB RMDN3 RNF32 SCAF11 SCN1A ST13 STAMBPL1 TCF4 TCF7L2 TDP2 TUBA1B UBQLN1 UMPS YME1L1	24 interactors: A2M ADRB2 AP1M2 APP CASK CHM CHML DMXL2 ECSIT EGFR MAST1 PSEN1 RAB3IL1 RAB3IP RABAC1 RABGGTB RABIF RIMS1 RIMS2 RNF32 RPH3A RPH3AL SYTL4 SYTL5
Entrez ID		5663	5864
HPRD ID		00087	01535
Ensembl ID		ENSG00000080815	ENSG00000105649
Uniprot IDs		P49768	P20336
PDB IDs		2KR6
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Death Regulation Of Apoptotic Process Cell Development Notch Receptor Processing Nervous System Development Generation Of Neurons Cell Differentiation Regulation Of Signaling Positive Regulation Of Cell Death Neurogenesis Positive Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death System Development Execution Phase Of Apoptosis Neuron Differentiation Anatomical Structure Development Multicellular Organismal Development Cellular Response To Stimulus Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Negative Regulation Of Cell Death Developmental Process Neuron Projection Development Negative Regulation Of Programmed Cell Death Neuron Development Signaling Response To Stimulus Regulation Of Signal Transduction Regulation Of Neurogenesis Regulation Of Cell Differentiation Cell Communication Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Regulation Of Establishment Of Protein Localization Notch Signaling Pathway Positive Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Development Cell Projection Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Localization	Establishment Of Protein Localization Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Transport Intracellular Transport Cellular Protein Localization Exocytosis Intracellular Protein Transport Secretion Secretion By Cell Transport Vesicle-mediated Transport Protein Geranylgeranylation Regulation Of Catalytic Activity Protein Prenylation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Hydrolase Activity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Inhibitory Postsynaptic Membrane Potential Membrane Organization Neurotransmitter Secretion Regulation Of Signaling Establishment Of Organelle Localization Regulation Of Neurotransmitter Levels Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Protein Binding Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Exocytosis Positive Regulation Of GTPase Activity Neurological System Process Endoplasmic Reticulum Calcium Ion Homeostasis Neurotransmitter Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Organelle Localization Visual Perception Membrane Hyperpolarization Regulation Of GTPase Activity Sensory Perception Of Light Stimulus Vesicle Targeting Positive Regulation Of Membrane Potential Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Vesicle Localization Regulation Of Vasodilation
Tagcloud ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy mapt neuropathological pd publically publication shifted tar variants	abundant adenohypophyseal anterior att cellubrevin corticotroph endocrine exocytosis fractionation fractions granules immunoblotting immunocytochemical isoform location microvesicles organelles pituitary represented secretory snap subcellular synaptic synaptobrevin synaptophysin synaptotagmin syntaxin took vesicles
Tagcloud (Difference) ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy mapt neuropathological pd publically publication shifted tar variants	abundant adenohypophyseal anterior att cellubrevin corticotroph endocrine exocytosis fractionation fractions granules immunoblotting immunocytochemical isoform location microvesicles organelles pituitary represented secretory snap subcellular synaptic synaptobrevin synaptophysin synaptotagmin syntaxin took vesicles
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