FBXL12 and DOCK8

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, two hybrid)

		FBXL12	DOCK8
Description		F-box and leucine rich repeat protein 12	dedicator of cytokinesis 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol	Cytoplasm Cytosol Plasma Membrane Membrane Cell Leading Edge Leading Edge Membrane Lamellipodium Membrane Cell Projection
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Immunological Synapse Formation Small GTPase-mediated Signal Transduction Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Non-syndromic autosomal dominant mental retardation
GWAS		Pursuit maintenance gain ( 29064472)	Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 27863252 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Post bronchodilator FEV1 ( 26634245) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		19 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FBF1 FXYD3 GEMIN4 LNX1 MAST1 PSEN1 PSEN2 PSME3 RNF32 SMAD1 TGFBR1 UBE2D3	27 interacting genes: BYSL CARHSP1 CDC42 CEBPA CHMP2A COG6 DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ HSF2BP KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581
Entrez ID		54850	81704
HPRD ID		12363	10920
Ensembl ID		ENSG00000127452	ENSG00000107099
Uniprot IDs		Q9NXK8	E2J6M5 E2J6M6 Q8NF50
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Regulation Of Amyloid Fibril Formation I-SMAD Binding Amyloid Precursor Protein Catabolic Process	GBD Domain Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Membrane Invagination Thioesterase Binding GTPase Activity Golgi Transport Complex Establishment Or Maintenance Of Cell Polarity GTP Binding Cytoplasmic Exosome (RNase Complex)
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?