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FBXL12 and DOCK8
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
FBXL12
DOCK8
Gene Name
F-box and leucine-rich repeat protein 12
dedicator of cytokinesis 8
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Cytoplasm
Cytosol
Membrane
Cell Leading Edge
Molecular Function
Protein Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Immunological Synapse Formation
Small GTPase Mediated Signal Transduction
Blood Coagulation
Dendritic Cell Migration
Positive Regulation Of GTPase Activity
Memory T Cell Proliferation
Negative Regulation Of T Cell Apoptotic Process
Pathways
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Mean platelet volume (
22139419
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
14 interactors:
A2M
APOE
CDC37
CDKN1C
DOCK8
ECSIT
FXYD3
LNX1
MAST1
PSEN1
PSEN2
RNF32
SMAD1
TGFBR1
25 interactors:
BYSL
CARHSP1
CDC42
CHMP2A
DGCR6
EXOSC5
FAM124A
FAM161A
FANCL
FBXL12
HBZ
KRT40
LRCH1
LRCH3
MED30
MEOX2
MRPL38
MTG1
RAC1
RHOJ
RHOQ
RTP5
SMAD2
ZFC3H1
ZNF581
Entrez ID
54850
81704
HPRD ID
12363
10920
Ensembl ID
ENSG00000127452
ENSG00000107099
Uniprot IDs
Q9NXK8
E2J6M5
E2J6M6
Q8NF50
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Catalytic Activity
Embryonic Morphogenesis
Intracellular Signal Transduction
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Thymus Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Generation Of Neurons
Amyloid Precursor Protein Catabolic Process
Anatomical Structure Morphogenesis
Neurogenesis
Regulation Of Protein Phosphorylation
Cell Fate Commitment
Neuron Differentiation
Embryo Development
Negative Regulation Of Protein Phosphorylation
Cell Activation
Response To Wounding
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorylation
Beta-amyloid Metabolic Process
Amyloid Precursor Protein Metabolic Process
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Phosphorylation
Membrane Protein Ectodomain Proteolysis
Notch Receptor Processing
Response To Cholesterol
Regulation Of Protein Binding
Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Nervous System Development
Regulation Of Cell Death
Regulation Of Synaptic Plasticity
Regulation Of Cell Morphogenesis
Pattern Specification Process
Regulation Of Cell Projection Organization
Neuron Development
Gland Development
Cell Differentiation
Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Metabolic Process
Response To Stress
Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Endothelial Cell Proliferation
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Anatomical Structure Morphogenesis
Posttranscriptional Regulation Of Gene Expression
Ribosome Biogenesis
Regulation Of Cellular Component Organization
Regulation Of Cytoskeleton Organization
Regulation Of Organelle Organization
Regulation Of Filopodium Assembly
Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Regulation Of Centriole Elongation
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Lipid Kinase Activity
Anatomical Structure Formation Involved In Morphogenesis
Actin Cytoskeleton Organization
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of DNA Replication
Small GTPase Mediated Signal Transduction
Positive Regulation Of Cell Projection Organization
Cell Projection Assembly
Embryonic Olfactory Bulb Interneuron Precursor Migration
Negative Regulation Of Interleukin-23 Production
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Positive Regulation Of Hair Follicle Cell Proliferation
Actin Filament-based Process
T Cell Costimulation
Positive Regulation Of Cellular Component Biogenesis
Ribonucleoprotein Complex Biogenesis
Embryonic Pattern Specification
Regulation Of Protein Complex Assembly
Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Engulfment Of Apoptotic Cell
Submandibular Salivary Gland Formation
Actin Filament Branching
Zygotic Specification Of Dorsal/ventral Axis
Regulation Of Small GTPase Mediated Signal Transduction
Anatomical Structure Development
Ephrin Receptor Signaling Pathway
Intracellular Signal Transduction
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Mast Cell Chemotaxis
Regulation Of Hair Follicle Cell Proliferation
Positive Regulation Of Synapse Structural Plasticity
Palate Development
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Mitotic Nuclear Division
Tagcloud
?
akr1c4
anomalies
apparently
array
balanced
bases
cdon
cgh
chrna7
confirming
dd
diagnoses
gata3
id
indistinguishable
inherited
intellectual
karyotype
karyotyping
mb
mca
nr2f2
overlooked
prenatal
pws
rearrangements
spanning
tier
tp63
Tagcloud (Difference)
?
akr1c4
anomalies
apparently
array
balanced
bases
cdon
cgh
chrna7
confirming
dd
diagnoses
gata3
id
indistinguishable
inherited
intellectual
karyotype
karyotyping
mb
mca
nr2f2
overlooked
prenatal
pws
rearrangements
spanning
tier
tp63
Tagcloud (Intersection)
?