FBXL12 and RNF32

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid, pull down)

		FBXL12	RNF32
Gene Name		F-box and leucine-rich repeat protein 12	ring finger protein 32
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm	Endosome Aggresome
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: A2M APOE CDC37 CDKN1C DOCK8 ECSIT FXYD3 LNX1 MAST1 PSEN1 PSEN2 RNF32 SMAD1 TGFBR1	42 interactors: A2M APOE APP BLMH CDC37 CDK5 CEP55 CYP2C8 CYP2C9 ECSIT ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 FIBP GCDH HOXC4 IFIT3 IFIT5 LONP1 LOXL4 LZTS2 MAST1 MGEA5 MKRN3 MNAT1 NOS3 PAXIP1 PRAM1 PRDX2 PSEN1 PSEN2 RAB3A RAB3D RAD23A RPP30 STAMBPL1 TRIM23 TRIM74 UBE2K
Entrez ID		54850	140545
HPRD ID		12363	11517
Ensembl ID		ENSG00000127452	ENSG00000105982
Uniprot IDs		Q9NXK8	Q9H0A6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Embryonic Morphogenesis Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Thymus Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Generation Of Neurons Amyloid Precursor Protein Catabolic Process Anatomical Structure Morphogenesis Neurogenesis Regulation Of Protein Phosphorylation Cell Fate Commitment Neuron Differentiation Embryo Development Negative Regulation Of Protein Phosphorylation Cell Activation Response To Wounding Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Phosphorylation Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Response To Cholesterol Regulation Of Protein Binding Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Nervous System Development Regulation Of Cell Death Regulation Of Synaptic Plasticity Regulation Of Cell Morphogenesis Pattern Specification Process Regulation Of Cell Projection Organization Neuron Development Gland Development Cell Differentiation Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Metabolic Process Response To Stress Dorsal/ventral Neural Tube Patterning Negative Regulation Of Endothelial Cell Proliferation	Catabolic Process Exocytosis Synaptic Vesicle Exocytosis Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Protein Metabolic Process Regulation Of Synaptic Plasticity Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Response To Stress Response To Stimulus Endoplasmic Reticulum Calcium Ion Homeostasis Secretion By Cell Neurotransmitter Secretion Synaptic Vesicle Transport Regulation Of Protein Metabolic Process Regulation Of Receptor Activity Negative Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process Cellular Response To Stimulus Establishment Of Localization In Cell Cellular Macromolecule Catabolic Process Secretion Regulation Of Neurotransmitter Levels Negative Regulation Of Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Omega-hydroxylase P450 Pathway Regulation Of Protein Binding Establishment Of Protein Localization Cellular Metabolic Process Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Vesicle Docking Involved In Exocytosis Regulation Of Synaptic Transmission Intracellular Signal Transduction Positive Regulation Of Exocytosis Neurotransmitter Transport Negative Regulation Of Cell Death Neuron Death Regulation Of Protein Kinase Activity Establishment Of Organelle Localization Synapse Organization Protein Localization Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Oxidative Demethylation Regulation Of Kinase Activity Negative Regulation Of Neuron Differentiation Regulation Of ERBB Signaling Pathway
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