CHERP and SNRNP70

Number of citations of the paper that reports this interaction (PubMedID 29802200)
80

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CHERP	SNRNP70
Description		calcium homeostasis endoplasmic reticulum protein	small nuclear ribonucleoprotein U1 subunit 70
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck Lysosomal Lumen U2-type Prespliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Transmembrane Transporter Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding U1 SnRNA Binding U1 SnRNP Binding
	Biological Process	RNA Processing Intracellular Calcium Ion Homeostasis Nervous System Development Negative Regulation Of Cell Population Proliferation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Calcineurin-NFAT Signaling Cascade	MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Cellular Response To Retinoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chaperone-mediated Autophagy
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653) Venous thromboembolism ( 33592630)
Interacting Genes		48 interacting genes: ADAMTSL4 AGGF1 APBB1 ARGLU1 C1orf94 CCAR1 CLK3 EWSR1 FASTK FIGN FRA10AC1 HNRNPH3 KRTAP11-1 LASP1 LUC7L MAGED1 MECOM MIR106B MIR200C MIR363 MIRLET7A2 MIRLET7C MIRLET7D MIRLET7E MIRLET7G MIRLET7I PPIL4 PRPF38A PRPF40A RACK1 RBFOX2 RBM23 RBM39 RBM7 RNPS1 SART1 SAXO1 SF3B4 SNRNP27 SNRNP70 SORBS3 SRPK1 SRPK2 TLE3 TTC14 U2AF1 USP54 WBP4	67 interacting genes: ADARB1 APP ARSF BACE2 CASP3 CBS CDC42 CDKL3 CEBPA CEP63 CFAP298 CHERP CRP CTDP1 DDX17 DYRK1A FTCD GATD3 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 HUNK IL32 IL7R ITSN1 LRP1 MYC NUDT21 OGT PDE9A PIGP PRKD2 PRMT5 PRPF40A PRPF6 PSMG1 RASGRF1 RBM11 RELA RIPPLY3 RNF11 RSPH1 RUNX1 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SPATC1L SRPK1 SRRM4 SRSF1 SRSF10 SRSF2 SUMO3 TIAM1 USP25 USP7 WBP4 ZRANB2
Entrez ID		10523	6625
HPRD ID		13051	01617
Ensembl ID		ENSG00000085872	ENSG00000104852
Uniprot IDs		Q8IWX8	P08621 Q9UFS1
PDB IDs			2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9 7B0Y 7VPX 8R08
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions RNA Binding Regulation Of MRNA Splicing, Via Spliceosome MiRNA-mediated Post-transcriptional Gene Silencing Nucleic Acid Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Nuclear Speck Regulation Of MRNA Processing RISC Complex Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing RNA Metabolic Process Spliceosomal Complex RS Domain Binding U1 SnRNP Binding Post-transcriptional Regulation Of Gene Expression Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process MRNA Cis Splicing, Via Spliceosome U2-type Precatalytic Spliceosome U2-type Prespliceosome Negative Regulation Of Macromolecule Biosynthetic Process U1 SnRNP Precatalytic Spliceosome Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Interleukin-6-mediated Signaling Pathway Extracellular Vesicle Nucleobase-containing Compound Metabolic Process MRNA Destabilization RNA Destabilization Regulation Of MRNA Stability Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Gene Expression	SMAD Protein Complex MRNA Processing Heteromeric SMAD Protein Complex RNA Metabolic Process RNA Processing RNA Splicing Nucleoplasm MRNA Metabolic Process Nucleic Acid Metabolic Process I-SMAD Binding Regulation Of MRNA Splicing, Via Spliceosome SMAD Protein Signal Transduction RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Growth Factor Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Positive Regulation Of Developmental Process Identical Protein Binding Embryonic Pattern Specification Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Primary MiRNA Processing Cardiac Conduction System Development Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Transcription Spliceosomal SnRNP Assembly Nuclear Speck Positive Regulation Of Cell Differentiation Spliceosomal Complex Assembly Protein-containing Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression DEAD/H-box RNA Helicase Binding RNA Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process
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