PLEC and ACTC1

Number of citations of the paper that reports this interaction (PubMedID 12136158)
0

Data Source:
HPRD (in vivo)

		PLEC	ACTC1
Description		plectin	actin alpha cardiac muscle 1
Image
GO Annotations	Cellular Component	Podosome Cytoplasm Mitochondrial Outer Membrane Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Sarcoplasm Myofibril Z Disc Hemidesmosome Axon Dendrite Sarcolemma Cell Projection Costamere Myelin Sheath Contractile Muscle Fiber Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Cell Periphery	Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Synapse Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	Dystroglycan Binding RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Ankyrin Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Microfilament Motor Activity Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Myosin Binding
	Biological Process	Cell Morphogenesis Leukocyte Migration Involved In Immune Response Keratinocyte Development Nucleus Organization Mitochondrion Organization Actin Filament Organization Skeletal Muscle Tissue Development Intracellular Protein Localization Gene Expression Fibroblast Migration T Cell Chemotaxis Skeletal Myofibril Assembly Transmission Of Nerve Impulse Myelination In Peripheral Nervous System Respiratory Electron Transport Chain Actin Cytoskeleton Organization Keratinocyte Differentiation Hemidesmosome Assembly Response To Food Peripheral Nervous System Myelin Maintenance Adherens Junction Organization Multicellular Organism Growth Wound Healing Regulation Of Vascular Permeability Skin Development Protein-containing Complex Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Sarcomere Organization Myoblast Differentiation Skeletal Muscle Fiber Development Cell Motility Cardiac Muscle Cell Development Establishment Of Skin Barrier Cellular Response To Mechanical Stimulus Cellular Response To Hydrostatic Pressure Cellular Response To Fluid Shear Stress Tight Junction Organization Actomyosin Contractile Ring Assembly Actin Filament Organization	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Cytoplasmic Actin-based Contraction Involved In Cell Motility Mesenchyme Migration
Pathways		Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly	Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)	Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS		Anti-saccade response ( 29064472) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 34002096 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fibrinogen levels ( 26561523 28107422) Haemorrhoidal disease ( 33888516) Height ( 31562340) Hip index ( 34021172) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Left ventricular ejection fraction (MTAG) ( 33495596) Left ventricular global radial strain (MTAG) ( 33495596) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 27863252 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Periodontitis (stage III/IV grade C) ( 33745150) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)	Axial length ( 24144296) Refractive error ( 20835239 32231278)
Interacting Genes		31 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 DSCAM EGFR ITGA6 ITGB4 KEAP1 LMNB1 MAP2 MSN MTDH NEIL3 PLEKHA5 PTEN RACK1 RSPH1 SMAD9 SNAPIN SPATC1L SPTA1 SPTAN1 SUMO2 UBC USP7 VIM WEE2-AS1	43 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 LINC00624 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		5339	70
HPRD ID		03180	00015
Ensembl ID		ENSG00000178209	ENSG00000159251
Uniprot IDs		A0A8I5KSD5 A0A8I5KUE3 H0YDN1 Q15149	B3KPP5 P68032
PDB IDs		1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I	8GSU 8GSW 8GT1 8GT2 8GT3 8GT4 8GT5 8ZB7 8ZI9 8ZJ1 9B3Q 9B3R
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoskeleton Organization Organelle Organization Developmental Process Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Cytoskeleton Regulation Of Cellular Localization Cell Junction Assembly Cell Projection Focal Adhesion Cell Junction Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Neuregulin Binding Cytosol Regulation Of Cellular Component Organization Hemidesmosome Assembly Cell-substrate Junction Assembly Regulation Of Protein Catabolic Process Nail Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteolysis Cell-substrate Junction Organization Positive Regulation Of Catabolic Process Negative Regulation Of Neuron Projection Development Positive Regulation Of Biosynthetic Process Spectrin-associated Cytoskeleton Hemidesmosome Regulation Of Cellular Component Size Cell Projection Organization Neuron Projection Morphogenesis Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Regulation Of Neuron Projection Development Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Spectrin Cellular Component Assembly Cell Projection Morphogenesis Cytoplasm Ubiquitin Protein Ligase Binding Cell-cell Adhesion Cadherin Binding Positive Regulation Of Membrane Depolarization Basal Plasma Membrane Cellular Developmental Process Skin Morphogenesis	Actin Binding Actin Cytoskeleton Actin Filament Binding Cytoskeleton Actin Filament-based Process Actin Filament Organization Cytoplasm Focal Adhesion Regulation Of Lamellipodium Assembly Actin Filament Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Myofibril Cell Projection Assembly Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Regulation Of Cell Projection Organization Cortical Cytoskeleton Z Disc Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Assembly Filopodium Regulation Of Actin Cytoskeleton Organization Stress Fiber Plasma Membrane Bounded Cell Projection Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Regulation Of Actin Filament-based Process Cell Projection Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Brush Border Regulation Of Actin Filament Polymerization Actin Filament-based Movement Extracellular Exosome Cytosol Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament Organization Cell Projection Organization
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