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PLEC and CDK1
Number of citations of the paper that reports this interaction (PubMedID
8626512
)
0
Data Source:
HPRD
(in vitro, in vivo)
PLEC
CDK1
Description
plectin
cyclin dependent kinase 1
Image
GO Annotations
Cellular Component
Podosome
Cytoplasm
Mitochondrial Outer Membrane
Cytosol
Cytoskeleton
Intermediate Filament
Plasma Membrane
Brush Border
Focal Adhesion
Sarcoplasm
Myofibril
Z Disc
Hemidesmosome
Axon
Dendrite
Sarcolemma
Cell Projection
Costamere
Myelin Sheath
Contractile Muscle Fiber
Intermediate Filament Cytoskeleton
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Anchoring Junction
Cell Periphery
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Spindle
Cytosol
Cytoskeleton
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin A1-CDK1 Complex
Cyclin A2-CDK1 Complex
Cyclin B1-CDK1 Complex
Molecular Function
Dystroglycan Binding
RNA Binding
Actin Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Cytoskeletal Protein Binding
Structural Constituent Of Muscle
Ankyrin Binding
Identical Protein Binding
Cadherin Binding
Actin Filament Binding
Nucleotide Binding
Virus Receptor Activity
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Transferase Activity
Cyclin Binding
Hsp70 Protein Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
Protein Serine Kinase Activity
Biological Process
Cell Morphogenesis
Leukocyte Migration Involved In Immune Response
Keratinocyte Development
Nucleus Organization
Mitochondrion Organization
Actin Filament Organization
Skeletal Muscle Tissue Development
Intracellular Protein Localization
Gene Expression
Fibroblast Migration
T Cell Chemotaxis
Skeletal Myofibril Assembly
Transmission Of Nerve Impulse
Myelination In Peripheral Nervous System
Respiratory Electron Transport Chain
Actin Cytoskeleton Organization
Keratinocyte Differentiation
Hemidesmosome Assembly
Response To Food
Peripheral Nervous System Myelin Maintenance
Adherens Junction Organization
Multicellular Organism Growth
Wound Healing
Regulation Of Vascular Permeability
Skin Development
Protein-containing Complex Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament Organization
Sarcomere Organization
Myoblast Differentiation
Skeletal Muscle Fiber Development
Cell Motility
Cardiac Muscle Cell Development
Establishment Of Skin Barrier
Cellular Response To Mechanical Stimulus
Cellular Response To Hydrostatic Pressure
Cellular Response To Fluid Shear Stress
Tight Junction Organization
Actomyosin Contractile Ring Assembly Actin Filament Organization
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Nuclear Envelope Organization
Mitotic Nuclear Membrane Disassembly
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Pronuclear Fusion
Response To Toxic Substance
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Response To Amine
Response To Activity
Cell Migration
Protein Deubiquitination
Peptidyl-threonine Phosphorylation
Chromosome Condensation
Epithelial Cell Differentiation
Protein Localization To Kinetochore
Positive Regulation Of Protein Import Into Nucleus
Response To Hydrogen Peroxide
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Mitotic Cell Cycle Phase Transition
Response To Ethanol
Positive Regulation Of DNA Replication
Regulation Of Embryonic Development
Thymidine Biosynthetic Process
Response To Cadmium Ion
Response To Copper Ion
Symbiont Entry Into Host Cell
Microtubule Polymerization
Fibroblast Proliferation
Rhythmic Process
Response To Axon Injury
Cell Division
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Cilium Disassembly
Positive Regulation Of Mitotic Sister Chromatid Segregation
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
ERK1 And ERK2 Cascade
Golgi Disassembly
DNA Strand Resection Involved In Replication Fork Processing
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Microtubule Cytoskeleton Organization Involved In Mitosis
DNA Synthesis Involved In Mitotic DNA Replication
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Protein Localization To Site Of Double-strand Break
Mitotic DNA-templated DNA Replication
Pathways
Assembly of collagen fibrils and other multimeric structures
Caspase-mediated cleavage of cytoskeletal proteins
Type I hemidesmosome assembly
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerization of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
PKR-mediated signaling
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
Seliciclib
AT-7519
Fostamatinib
Avotaciclib
Diseases
Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)
GWAS
Anti-saccade response (
29064472
)
Apolipoprotein B levels (
32203549
)
Bipolar disorder (
34002096
31043756
)
Bipolar I disorder (
31043756
)
Brain morphology (MOSTest) (
32665545
)
Diastolic blood pressure (
30224653
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Fibrinogen levels (
26561523
28107422
)
Haemorrhoidal disease (
33888516
)
Height (
31562340
)
Hip index (
34021172
)
Knee osteoarthritis (
28916551
)
LDL cholesterol (
30275531
)
LDL cholesterol levels (
32203549
)
Left ventricular ejection fraction (MTAG) (
33495596
)
Left ventricular global radial strain (MTAG) (
33495596
)
Low density lipoprotein cholesterol levels (
32154731
)
Mean platelet volume (
27863252
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Mosquito bite size (
28199695
)
Periodontitis (stage III/IV grade C) (
33745150
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Post bronchodilator FEV1 (
26634245
)
PR interval (
32439900
)
Red blood cell count (
32888494
)
Resting heart rate (
27798624
)
Total cholesterol levels (
30275531
)
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Interacting Genes
31 interacting genes:
ACTC1
ACTG1
ANK3
BRCA2
CASP8
CDK1
COL17A1
DSCAM
EGFR
ITGA6
ITGB4
KEAP1
LMNB1
MAP2
MSN
MTDH
NEIL3
PLEKHA5
PTEN
RACK1
RSPH1
SMAD9
SNAPIN
SPATC1L
SPTA1
SPTAN1
SUMO2
UBC
USP7
VIM
WEE2-AS1
241 interacting genes:
ABL1
ACSL4
ADD1
AKAP12
AKT1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BCL2L11
BIRC5
BIRC6
BRCA1
BRCA2
BTG2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDCA2
CDCA5
CDK7
CDKN1A
CDKN3
CDT1
CEBPA
CENPF
CEP55
CEP63
CHAF1B
CIITA
CIP2A
CKS2
CNOT7
CREB1
CREM
CSN2
CSNK2A1
CSNK2B
CTNNB1
CUL4B
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EML3
EPN1
ERCC2
ERCC6L
FANCA
FANCC
FANCG
FBXO5
FEN1
FLNA
FOXM1
FOXO1
FYN
GADD45A
GADD45B
GADD45G
GAS2L3
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HASPIN
HJURP
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
ID2
IDH1
IDH2
IL16
IL3RA
IQGAP1
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LRRK1
LYN
LZTS1
MAP4
MAPK12
MAPT
MBP
MCM2
MCM4
MDM4
MEF2C
MIS18BP1
MISP
MKI67
MLKL
MLST8
MNDA
MYC
MYT1
NCAPD2
NCAPD3
NCAPG
NCAPH
NCL
NDE1
NEDD1
NES
NHERF1
NONO
NPM1
NSFL1C
NUP210
PAK6
PBK
PCM1
PCNA
PIN1
PIP5K1C
PITPNM1
PKMYT1
PLEC
PML
POLA1
POLL
PON1
PPP1R12A
PPP2R1A
PPP2R1B
PPP2R2B
PPP4R2
PPP4R3A
PRC1
PRDX1
PRDX2
PRKAR2A
PSRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAD9A
RANGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RGCC
RPA2
RPS3
RPS6KB1
RRM2
RSF1
RUNX1
RUNX2
SAMHD1
SFN
SLBP
SOX2
SP1
SPAG5
SQSTM1
SRC
SSBP1
STK3
STMN1
STMN2
TERF1
TFDP1
TGFBR2
TK1
TLE1
TMPO
TNNC1
TOP2A
TP53
TP53BP1
TP73
TPR
TSC1
TSPYL2
TUBB
UBA1
UBE2A
UBE3A
UHRF2
USP14
USP16
VHL
VIM
WAC
WEE1
XIAP
XPO1
XRCC6
ZBTB16
Entrez ID
5339
983
HPRD ID
03180
00302
Ensembl ID
ENSG00000178209
ENSG00000170312
Uniprot IDs
A0A8I5KSD5
A0A8I5KUE3
H0YDN1
Q15149
B7Z3D6
I6L9I5
P06493
PDB IDs
1MB8
2N03
2ODU
2ODV
3F7P
3PDY
3PE0
4GDO
4Q58
4Q59
5J1F
5J1G
5J1H
5J1I
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
6TWN
7NJ0
Enriched GO Terms of Interacting Partners
?
Structural Constituent Of Cytoskeleton
Cytoskeleton Organization
Organelle Organization
Developmental Process
Positive Regulation Of Metabolic Process
Anatomical Structure Morphogenesis
Cytoskeleton
Regulation Of Cellular Localization
Cell Junction Assembly
Cell Projection
Focal Adhesion
Cell Junction Organization
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteolysis
Neuregulin Binding
Cytosol
Regulation Of Cellular Component Organization
Hemidesmosome Assembly
Cell-substrate Junction Assembly
Regulation Of Protein Catabolic Process
Nail Development
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Proteolysis
Cell-substrate Junction Organization
Positive Regulation Of Catabolic Process
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Biosynthetic Process
Spectrin-associated Cytoskeleton
Hemidesmosome
Regulation Of Cellular Component Size
Cell Projection Organization
Neuron Projection Morphogenesis
Positive Regulation Of Intracellular Transport
Regulation Of Intracellular Transport
Regulation Of Neuron Projection Development
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Spectrin
Cellular Component Assembly
Cell Projection Morphogenesis
Cytoplasm
Ubiquitin Protein Ligase Binding
Cell-cell Adhesion
Cadherin Binding
Positive Regulation Of Membrane Depolarization
Basal Plasma Membrane
Cellular Developmental Process
Skin Morphogenesis
Regulation Of Cell Cycle
Regulation Of Cell Cycle Process
Cell Division
Nucleus
Cellular Response To Stress
Nucleoplasm
DNA Damage Response
Regulation Of Mitotic Cell Cycle
Organelle Organization
Cytosol
Cytoplasm
Regulation Of Cell Cycle Phase Transition
Chromosome
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Cycle
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Cell Cycle Phase Transition
Intracellular Signal Transduction
Positive Regulation Of Cell Cycle Process
Negative Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Chromosome Organization
DNA Metabolic Process
Response To Stress
Negative Regulation Of Macromolecule Metabolic Process
DNA Repair
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Population Proliferation
Cytoskeleton
Regulation Of DNA Metabolic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Cell Cycle Process
Positive Regulation Of Apoptotic Process
Protein Kinase Binding
Regulation Of Protein Metabolic Process
Regulation Of Cellular Component Organization
Cell Cycle G2/M Phase Transition
Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Binding
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Intracellular Signal Transduction
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Component Assembly
Negative Regulation Of Mitotic Cell Cycle
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Tagcloud (Intersection)
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