PLEC and ITGB4

Number of citations of the paper that reports this interaction (PMID 14668477)
26

Data Source:
HPRD (two hybrid, in vivo)

		PLEC	ITGB4
Gene Name		plectin	integrin, beta 4
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Sarcoplasm Hemidesmosome Sarcolemma Costamere Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Basement Membrane Plasma Membrane Integrin Complex Basal Plasma Membrane Cell Surface Hemidesmosome Cell Leading Edge Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Ankyrin Binding Poly(A) RNA Binding	G-protein Coupled Receptor Binding Receptor Activity Protein Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly	Autophagy Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly Nail Development Skin Development Filopodium Assembly Mesodermal Cell Differentiation Digestive Tract Development Cell Motility Renal System Development Amelogenesis
Pathways		Cell junction organization Apoptotic cleavage of cellular proteins Type I hemidesmosome assembly Collagen formation Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins Assembly of collagen fibrils and other multimeric structures	Cell junction organization Syndecan interactions Type I hemidesmosome assembly Collagen formation Laminin interactions Non-integrin membrane-ECM interactions Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ACTC1 ACTG1 CASP8 CDK1 COL17A1 EGFR GNB2L1 ITGA6 ITGB4 LMNB1 MAP2 MSN PLEKHA5 SMAD9 SPTA1 SPTAN1 VIM	23 interactors: ALOX12 ATXN1 CLCA1 CLCA2 COL17A1 DST EIF6 ERBB2 ERBB2IP FYN GRB2 ITGA6 MET PLEC PRKCA PRKCD PTK2 SHC1 SREBF2 VIM YES1 YWHAB YWHAQ
Entrez ID		5339	3691
HPRD ID		03180	00946
Ensembl ID		ENSG00000178209	ENSG00000132470
Uniprot IDs		Q15149	P16144
PDB IDs		1MB8 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO	1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A
Enriched GO Terms of Interacting Partners?		Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Cell Differentiation Tissue Development Hemidesmosome Assembly Multicellular Organismal Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis System Development Execution Phase Of Apoptosis Cell Projection Organization Locomotion Cell Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Apoptotic Process Programmed Cell Death Neuron Projection Morphogenesis Cell Death Death Epithelium Development Cell-substrate Junction Assembly Axon Guidance Cell Morphogenesis Involved In Differentiation Nervous System Development Cell Adhesion Cell Junction Assembly Neuron Projection Development Nail Development Cell Projection Morphogenesis Cell Part Morphogenesis Single Organismal Cell-cell Adhesion Neuron Development Negative Regulation Of Cell Death Chemotaxis Generation Of Neurons Amelogenesis Cell Morphogenesis Organ Development Filopodium Assembly Neurogenesis Neuron Differentiation Cytoskeleton Organization Tube Development Astrocyte Development Digestive Tract Development Response To Ethanol Response To External Stimulus	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Fibroblast Growth Factor Receptor Signaling Pathway Response To Wounding Cellular Response To Fibroblast Growth Factor Stimulus Hemidesmosome Assembly Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Growth Factor Wound Healing Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Blood Coagulation Hemostasis Locomotion Immune Response-regulating Signaling Pathway Platelet Activation Protein Autophosphorylation Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Chemotaxis Axon Guidance Leukocyte Migration Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Apoptotic Process Cell-substrate Junction Assembly Regulation Of Cell Activation Programmed Cell Death Cell Death Death Cellular Response To Peptide Hormone Stimulus Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Organic Substance Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Platelet Aggregation Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway
Tagcloud ?		actn1 b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Difference) ?		actn1 b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plectin pycard pyd rpkm s100a2 signalings stratifin subpathway sum149 sum190 tfrc	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpine1 thbs1 thbs2
Tagcloud (Intersection) ?		serpinb5