PLEC and COL17A1

Number of citations of the paper that reports this interaction (PMID 12482924)
29

Data Source:
HPRD (in vitro, two hybrid)

		PLEC	COL17A1
Gene Name		plectin	collagen, type XVII, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Sarcoplasm Hemidesmosome Sarcolemma Costamere Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Hemidesmosome
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Ankyrin Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly	Cell-matrix Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Hemidesmosome Assembly Cell Junction Assembly
Pathways		Cell junction organization Apoptotic cleavage of cellular proteins Type I hemidesmosome assembly Collagen formation Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins Assembly of collagen fibrils and other multimeric structures	Cell junction organization Type I hemidesmosome assembly Collagen formation Collagen degradation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS			Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		17 interactors: ACTC1 ACTG1 CASP8 CDK1 COL17A1 EGFR GNB2L1 ITGA6 ITGB4 LMNB1 MAP2 MSN PLEKHA5 SMAD9 SPTA1 SPTAN1 VIM	12 interactors: ACTN1 ACTN4 CLSTN1 CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PPL
Entrez ID		5339	1308
HPRD ID		03180	00223
Ensembl ID		ENSG00000178209	ENSG00000065618
Uniprot IDs		Q15149	Q9UMD9
PDB IDs		1MB8 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO
Enriched GO Terms of Interacting Partners?		Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Cell Differentiation Tissue Development Hemidesmosome Assembly Multicellular Organismal Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis System Development Execution Phase Of Apoptosis Cell Projection Organization Locomotion Cell Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Apoptotic Process Programmed Cell Death Neuron Projection Morphogenesis Cell Death Death Epithelium Development Cell-substrate Junction Assembly Axon Guidance Cell Morphogenesis Involved In Differentiation Nervous System Development Cell Adhesion Cell Junction Assembly Neuron Projection Development Nail Development Cell Projection Morphogenesis Cell Part Morphogenesis Single Organismal Cell-cell Adhesion Neuron Development Negative Regulation Of Cell Death Chemotaxis Generation Of Neurons Amelogenesis Cell Morphogenesis Organ Development Filopodium Assembly Neurogenesis Neuron Differentiation Cytoskeleton Organization Tube Development Astrocyte Development Digestive Tract Development Response To Ethanol Response To External Stimulus See more	Cell Junction Assembly Hemidesmosome Assembly Cell-substrate Junction Assembly Protein Localization To Cell Junction Protein Localization To Tight Junction Cell Adhesion Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cell-cell Junction Organization Skin Development Cellular Component Assembly Nail Development Adherens Junction Organization Integrin-mediated Signaling Pathway Amelogenesis Actin Crosslink Formation Filopodium Assembly Cell-matrix Adhesion Cytoskeleton Organization Cell-substrate Adhesion Wound Healing Tight Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament Bundle Assembly Platelet Degranulation Golgi To Plasma Membrane CFTR Protein Transport Apical Junction Assembly Execution Phase Of Apoptosis Keratinocyte Differentiation Blood Coagulation Hemostasis Ventricular Compact Myocardium Morphogenesis Odontogenesis Of Dentin-containing Tooth Cell-cell Junction Assembly Positive Regulation Of Pinocytosis Single Organismal Cell-cell Adhesion Odontogenesis Positive Regulation Of Sodium:proton Antiporter Activity Protein Localization To Adherens Junction Epidermal Cell Differentiation Digestive Tract Development Regulation Of Body Fluid Levels Digestive System Development Response To Stress Regulation Of Sodium:proton Antiporter Activity Ectodermal Cell Differentiation Peroxisome Proliferator Activated Receptor Signaling Pathway See more
Tagcloud ?		actn1 b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	aligning alopecia atrophic blistering bullosa codons corrective correlating dystrophy enamel epidermolysis exons faulty harbouring herlitz hypoplasia introns jeb junctional milder mucous nail nh nonsense pitting premtrna repaired vicinity xvii
Tagcloud (Difference) ?		actn1 b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	aligning alopecia atrophic blistering bullosa codons corrective correlating dystrophy enamel epidermolysis exons faulty harbouring herlitz hypoplasia introns jeb junctional milder mucous nail nh nonsense pitting premtrna repaired vicinity xvii
Tagcloud (Intersection) ?