PLEC and SPTAN1

Number of citations of the paper that reports this interaction (PMID 3027087)
32

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PLEC	SPTAN1
Gene Name		plectin	spectrin, alpha, non-erythrocytic 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Sarcoplasm Hemidesmosome Sarcolemma Costamere Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Cytosol Fascia Adherens Spectrin Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Z Disc Vesicle Cuticular Plate Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Ankyrin Binding Poly(A) RNA Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Spectrin Binding Protein Heterodimerization Activity
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Axon Guidance Actin Filament Capping
Pathways		Cell junction organization Apoptotic cleavage of cellular proteins Type I hemidesmosome assembly Collagen formation Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins Assembly of collagen fibrils and other multimeric structures	Interaction between L1 and Ankyrins Apoptotic cleavage of cellular proteins Axon guidance Programmed Cell Death Apoptotic execution phase Nephrin interactions L1CAM interactions Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ACTC1 ACTG1 CASP8 CDK1 COL17A1 EGFR GNB2L1 ITGA6 ITGB4 LMNB1 MAP2 MSN PLEKHA5 SMAD9 SPTA1 SPTAN1 VIM	48 interactors: ABI1 ABL1 ACP1 ACTA1 ACTB ADD1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES DISC1 EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D MAPK6 NEFL PIN4 PLEC PLEKHA5 PRKCB PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SRC STAT1 SYN1 TANC1 TES TSSC4
Entrez ID		5339	6709
HPRD ID		03180	01684
Ensembl ID		ENSG00000178209	ENSG00000197694
Uniprot IDs		Q15149	Q13813
PDB IDs		1MB8 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO	2FOT 3F31 3FB2
Enriched GO Terms of Interacting Partners?		Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Cell Differentiation Tissue Development Hemidesmosome Assembly Multicellular Organismal Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis System Development Execution Phase Of Apoptosis Cell Projection Organization Locomotion Cell Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Apoptotic Process Programmed Cell Death Neuron Projection Morphogenesis Cell Death Death Epithelium Development Cell-substrate Junction Assembly Axon Guidance Cell Morphogenesis Involved In Differentiation Nervous System Development Cell Adhesion Cell Junction Assembly Neuron Projection Development Nail Development Cell Projection Morphogenesis Cell Part Morphogenesis Single Organismal Cell-cell Adhesion Neuron Development Negative Regulation Of Cell Death Chemotaxis Generation Of Neurons Amelogenesis Cell Morphogenesis Organ Development Filopodium Assembly Neurogenesis Neuron Differentiation Cytoskeleton Organization Tube Development Astrocyte Development Digestive Tract Development Response To Ethanol Response To External Stimulus	Cell Morphogenesis Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Organization Axon Development Cell Projection Morphogenesis Cell Development Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Neuron Differentiation Neuron Development Axon Guidance Cell Differentiation Neurogenesis Anatomical Structure Morphogenesis Generation Of Neurons Axonogenesis Neuromuscular Process Movement Of Cell Or Subcellular Component Ionotropic Glutamate Receptor Signaling Pathway Chemotaxis Organelle Organization System Development Synaptic Transmission, Glutamatergic Response To External Stimulus Anatomical Structure Development Homeostatic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Locomotion Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Membrane Depolarization Synaptic Transmission Neuron-neuron Synaptic Transmission Cellular Component Assembly Startle Response Actin Filament-based Process Developmental Process Regulation Of Excitatory Postsynaptic Membrane Potential Learning Multicellular Organismal Development Regulation Of Postsynaptic Membrane Potential Signaling Response To Wounding Cell Communication Cellular Response To Stimulus
Tagcloud ?		actn1 b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Difference) ?		actn1 b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Intersection) ?