PLEC and VIM

Number of citations of the paper that reports this interaction (PMID 3027087)
32

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PLEC	VIM
Gene Name		plectin	vimentin
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Sarcoplasm Hemidesmosome Sarcolemma Costamere Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Cytoplasm Peroxisome Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Cell Leading Edge Neuron Projection Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Ankyrin Binding Poly(A) RNA Binding	Glycoprotein Binding Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein C-terminus Binding Identical Protein Binding Scaffold Protein Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Astrocyte Development Viral Process Muscle Filament Sliding Intermediate Filament Organization Bergmann Glial Cell Differentiation SMAD Protein Signal Transduction Lens Fiber Cell Development
Pathways		Cell junction organization Apoptotic cleavage of cellular proteins Type I hemidesmosome assembly Collagen formation Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins Assembly of collagen fibrils and other multimeric structures	Apoptotic cleavage of cellular proteins Striated Muscle Contraction Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ACTC1 ACTG1 CASP8 CDK1 COL17A1 EGFR GNB2L1 ITGA6 ITGB4 LMNB1 MAP2 MSN PLEKHA5 SMAD9 SPTA1 SPTAN1 VIM	140 interactors: ABLIM1 AKT1 ALS2CR11 ANKRD35 ANXA7 APIP APLP1 APP ARMCX2 ATN1 BFSP1 BHLHE40 BRD1 CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CDH5 CDK1 CDKN1A CHD3 COPS6 CRCT1 CREB1 CRMP1 CWF19L2 DCTN1 DEFB1 DGCR14 DIS3L2 DNM1L DPPA4 DSP DYNLL1 EIF3I FABP4 FAM107A FAM118B FUBP1 GADD45A GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HTRA2 ING5 ITGB4 IVNS1ABP KARS KAT7 KIAA0408 KIAA1377 KIF15 KRT20 LOR LRIF1 MAFG MAN2A2 MEN1 MICAL1 MRPL44 NEFL NFATC2 NIF3L1 NME2 NOC4L NR1H2 NUP85 OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PLA2G2A PLA2G4A PLEC PNMA5 POLR1C PPHLN1 PPL PRKACA PRPH PSMA1 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM48 RIBC2 ROCK1 RPA1 SDCCAG3 SERBP1 SETDB1 SH3GL1 SH3GL3 SH3YL1 SIRT6 SLC25A6 SLC27A6 SMAD3 SRRT STX1A SUMO2 SUMO3 SYN1 TAB2 TCHP TNFRSF14 TNNT1 TRIM28 TRIM29 TRIOBP TSC22D1 TTR TUBGCP4 TXLNB TXN TXN2 UPP1 UPP2 UROD UTP14A WBP11 XRCC4 YAE1D1 YWHAE YWHAZ ZHX1 ZNF384
Entrez ID		5339	7431
HPRD ID		03180	01899
Ensembl ID		ENSG00000178209	ENSG00000026025
Uniprot IDs		Q15149	P08670
PDB IDs		1MB8 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO	1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1
Enriched GO Terms of Interacting Partners?		Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Cell Differentiation Tissue Development Hemidesmosome Assembly Multicellular Organismal Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis System Development Execution Phase Of Apoptosis Cell Projection Organization Locomotion Cell Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Apoptotic Process Programmed Cell Death Neuron Projection Morphogenesis Cell Death Death Epithelium Development Cell-substrate Junction Assembly Axon Guidance Cell Morphogenesis Involved In Differentiation Nervous System Development Cell Adhesion Cell Junction Assembly Neuron Projection Development Nail Development Cell Projection Morphogenesis Cell Part Morphogenesis Single Organismal Cell-cell Adhesion Neuron Development Negative Regulation Of Cell Death Chemotaxis Generation Of Neurons Amelogenesis Cell Morphogenesis Organ Development Filopodium Assembly Neurogenesis Neuron Differentiation Cytoskeleton Organization Tube Development Astrocyte Development Digestive Tract Development Response To Ethanol Response To External Stimulus	Programmed Cell Death Apoptotic Process Cell Death Death Execution Phase Of Apoptosis Regulation Of Cell Death Response To Abiotic Stimulus Regulation Of Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Positive Regulation Of Proteolysis Regulation Of Cellular Localization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Cellular Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Organelle Organization Cell Cycle Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Gene Expression Immune System Process Regulation Of Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Positive Regulation Of Signal Transduction Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Programmed Cell Death Cellular Process Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Viral Process Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		actn1 b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z
Tagcloud (Difference) ?		actn1 b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc	10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z
Tagcloud (Intersection) ?