PLEC and SPTA1

Number of citations of the paper that reports this interaction (PubMedID 3027087)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PLEC	SPTA1
Description		plectin	spectrin alpha, erythrocytic 1
Image
GO Annotations	Cellular Component	Podosome Cytoplasm Mitochondrial Outer Membrane Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Sarcoplasm Myofibril Z Disc Hemidesmosome Axon Dendrite Sarcolemma Cell Projection Costamere Myelin Sheath Contractile Muscle Fiber Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Cell Periphery	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Actin Cytoskeleton Membrane Cell Junction Axon Cortical Cytoskeleton Cortical Actin Cytoskeleton Cuticular Plate Cell Projection
	Molecular Function	Dystroglycan Binding RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Ankyrin Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Leukocyte Migration Involved In Immune Response Keratinocyte Development Nucleus Organization Mitochondrion Organization Actin Filament Organization Skeletal Muscle Tissue Development Intracellular Protein Localization Gene Expression Fibroblast Migration T Cell Chemotaxis Skeletal Myofibril Assembly Transmission Of Nerve Impulse Myelination In Peripheral Nervous System Respiratory Electron Transport Chain Actin Cytoskeleton Organization Keratinocyte Differentiation Hemidesmosome Assembly Response To Food Peripheral Nervous System Myelin Maintenance Adherens Junction Organization Multicellular Organism Growth Wound Healing Regulation Of Vascular Permeability Skin Development Protein-containing Complex Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Sarcomere Organization Myoblast Differentiation Skeletal Muscle Fiber Development Cell Motility Cardiac Muscle Cell Development Establishment Of Skin Barrier Cellular Response To Mechanical Stimulus Cellular Response To Hydrostatic Pressure Cellular Response To Fluid Shear Stress Tight Junction Organization Actomyosin Contractile Ring Assembly Actin Filament Organization	Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Actin Filament Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Hemopoiesis Positive Regulation Of T Cell Proliferation Actin Filament Capping
Pathways		Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)	Hereditary spherocytosis (SPH) Hereditary elliptocytosis (HE)
GWAS		Anti-saccade response ( 29064472) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 34002096 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fibrinogen levels ( 26561523 28107422) Haemorrhoidal disease ( 33888516) Height ( 31562340) Hip index ( 34021172) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Left ventricular ejection fraction (MTAG) ( 33495596) Left ventricular global radial strain (MTAG) ( 33495596) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 27863252 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Periodontitis (stage III/IV grade C) ( 33745150) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)	Glycated hemoglobin levels ( 20858683 34059833 28898252) Heel bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin A1c levels ( 29844224) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494 29403010) Mean corpuscular volume ( 32888494 29403010 27863252) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) Platelet distribution width ( 32888494) QRS duration ( 27577874) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 DSCAM EGFR ITGA6 ITGB4 KEAP1 LMNB1 MAP2 MSN MTDH NEIL3 PLEKHA5 PTEN RACK1 RSPH1 SMAD9 SNAPIN SPATC1L SPTA1 SPTAN1 SUMO2 UBC USP7 VIM WEE2-AS1	27 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 BCKDK C21orf58 CCDC185 CIMAP1B DGCR6L ENAH EVL EXOSC5 FANCC FASLG GADD45GIP1 KRT75 PKP2 PLEC SLC9A2 SPTB SPTBN2 TSHZ2 TXN2 VASP YWHAQ ZNF326
Entrez ID		5339	6708
HPRD ID		03180	01685
Ensembl ID		ENSG00000178209	ENSG00000163554
Uniprot IDs		A0A8I5KSD5 A0A8I5KUE3 H0YDN1 Q15149	P02549
PDB IDs		1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I	1OWA 3LBX 5J4O
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoskeleton Organization Organelle Organization Developmental Process Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Cytoskeleton Regulation Of Cellular Localization Cell Junction Assembly Cell Projection Focal Adhesion Cell Junction Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Neuregulin Binding Cytosol Regulation Of Cellular Component Organization Hemidesmosome Assembly Cell-substrate Junction Assembly Regulation Of Protein Catabolic Process Nail Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteolysis Cell-substrate Junction Organization Positive Regulation Of Catabolic Process Negative Regulation Of Neuron Projection Development Positive Regulation Of Biosynthetic Process Spectrin-associated Cytoskeleton Hemidesmosome Regulation Of Cellular Component Size Cell Projection Organization Neuron Projection Morphogenesis Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Regulation Of Neuron Projection Development Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Spectrin Cellular Component Assembly Cell Projection Morphogenesis Cytoplasm Ubiquitin Protein Ligase Binding Cell-cell Adhesion Cadherin Binding Positive Regulation Of Membrane Depolarization Basal Plasma Membrane Cellular Developmental Process Skin Morphogenesis	Supramolecular Fiber Organization Actin Filament Organization Actin Polymerization Or Depolymerization Structural Constituent Of Cytoskeleton Profilin Binding Cytoskeleton Regulation Of Actin Filament-based Process Cytoskeleton Organization Regulation Of Actin Filament Polymerization Actin Binding Regulation Of Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Filopodium Cadherin Binding Lamellipodium Regulation Of Actin Cytoskeleton Organization Actin Filament Binding Actin Cytoskeleton Organization Actin Filament Capping Regulation Of Supramolecular Fiber Organization SH3 Domain Binding Negative Regulation Of Actin Filament Depolymerization Actin Filament-based Process Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Size Focal Adhesion Negative Regulation Of Actin Filament Polymerization Spectrin-associated Cytoskeleton Regulation Of Actin Filament Depolymerization Spectrin Regulation Of Cytoskeleton Organization Intermediate Filament Organization Negative Regulation Of Protein-containing Complex Disassembly Cell Junction Regulation Of Protein Depolymerization Intermediate Filament Cytoskeleton Organization Ankyrin Binding Intermediate Filament-based Process Postsynapse Regulation Of Postsynaptic Specialization Assembly Cell Projection Cytoskeletal Anchor Activity Spectrin Binding Actin Cytoskeleton Skeletal Muscle Fiber Development Regulation Of Protein-containing Complex Disassembly Cellular Response To Fluid Shear Stress Myotube Cell Development Negative Regulation Of Protein-containing Complex Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?