PLEC and DSCAM

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PLEC	DSCAM
Description		plectin	DS cell adhesion molecule
Image
GO Annotations	Cellular Component	Podosome Cytoplasm Mitochondrial Outer Membrane Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Sarcoplasm Myofibril Z Disc Hemidesmosome Axon Dendrite Sarcolemma Cell Projection Costamere Myelin Sheath Contractile Muscle Fiber Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Cell Periphery	Extracellular Region Plasma Membrane Membrane Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Dystroglycan Binding RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Ankyrin Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Protein Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding Netrin Receptor Binding
	Biological Process	Cell Morphogenesis Leukocyte Migration Involved In Immune Response Keratinocyte Development Nucleus Organization Mitochondrion Organization Actin Filament Organization Skeletal Muscle Tissue Development Intracellular Protein Localization Gene Expression Fibroblast Migration T Cell Chemotaxis Skeletal Myofibril Assembly Transmission Of Nerve Impulse Myelination In Peripheral Nervous System Respiratory Electron Transport Chain Actin Cytoskeleton Organization Keratinocyte Differentiation Hemidesmosome Assembly Response To Food Peripheral Nervous System Myelin Maintenance Adherens Junction Organization Multicellular Organism Growth Wound Healing Regulation Of Vascular Permeability Skin Development Protein-containing Complex Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Sarcomere Organization Myoblast Differentiation Skeletal Muscle Fiber Development Cell Motility Cardiac Muscle Cell Development Establishment Of Skin Barrier Cellular Response To Mechanical Stimulus Cellular Response To Hydrostatic Pressure Cellular Response To Fluid Shear Stress Tight Junction Organization Actomyosin Contractile Ring Assembly Actin Filament Organization	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Axon Guidance Synapse Assembly Central Nervous System Development Locomotory Behavior Retina Layer Formation Social Behavior Synaptic Transmission, Glutamatergic Netrin-activated Signaling Pathway Positive Regulation Of Phosphorylation Dendrite Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Post-embryonic Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Dendritic Spine Development Dendrite Self-avoidance
Pathways		Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly	DSCAM interactions DSCAM interactions
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)
GWAS		Anti-saccade response ( 29064472) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 34002096 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fibrinogen levels ( 26561523 28107422) Haemorrhoidal disease ( 33888516) Height ( 31562340) Hip index ( 34021172) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Left ventricular ejection fraction (MTAG) ( 33495596) Left ventricular global radial strain (MTAG) ( 33495596) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 27863252 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Periodontitis (stage III/IV grade C) ( 33745150) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)	Adult body size ( 32376654) Anxiety in major depressive disorder ( 24047446) Blood protein levels ( 30072576) Fasting plasma glucose ( 31170924) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (Prevotella) ( 33208821) Hallux valgus ( 32131869) Intracranial aneurysm ( 30823506) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Mild to moderate chronic kidney disease ( 31178898) Neutrophil count ( 21507922) Non-small cell lung cancer (survival) ( 21079520) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systemising ( 31508503) Tuberculosis ( 24057671) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		31 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 DSCAM EGFR ITGA6 ITGB4 KEAP1 LMNB1 MAP2 MSN MTDH NEIL3 PLEKHA5 PTEN RACK1 RSPH1 SMAD9 SNAPIN SPATC1L SPTA1 SPTAN1 SUMO2 UBC USP7 VIM WEE2-AS1	157 interacting genes: ACO1 ACTN1 ACTN4 AFDN AMOTL2 AP2A1 AP2B1 APC2 ARCN1 ARIH2 ASTN1 ATP5F1B ATP6V1B2 ATRX BFSP1 BICD1 BTBD1 CADPS CAMK2A CAP2 CEP63 CFAP91 CIAO2B CIT CLTC CLU COG1 COG4 COPS5 CPNE5 CRTAC1 CSNK2B CUL9 CXXC5 DIP2A DLG1 DLG2 DLG4 DNAJA2 DPYSL2 DST DYNC1H1 DYRK1A EEF2 EIF3C ENC1 EYA3 FLNB GFAP GFPT1 GLUL GNPTAB GPRASP1 GUF1 HLA-A HNRNPF IFT122 IFT88 INTS8 IQGAP1 IST1 KALRN KCNN1 KDM4C KHDRBS1 KIF21A KIF3A KIF5A KIFC3 KLHL4 KPNB1 KRT222 KRT83 LARS1 LDB1 LIMK1 LMO2 LNX1 MACF1 MAGI2 MAGI3 MAP3K11 MAP4K4 MAT2A MERTK METAP1 METAP2 MITD1 MNAT1 MORF4L2 MPRIP MTA3 MTMR10 NAPA NAPB NCK1 NEFL NEFM NF2 NOMO2 NUP43 PAK1 PAX6 PDE4DIP PDLIM5 PIH1D2 PLEC POLDIP2 POLR3B PPP1R16B PRPF8 PSMD2 PTPN13 RAPGEF4 RCBTB1 RILPL1 ROBO1 RTL10 RUFY2 RUFY3 S100A10 SACS SDHA SEMA4D SEPTIN2 SGSM3 SHTN1 SIPA1L1 SKIL SOS2 SPTBN1 STAG1 STAT3 SUPT5H SUPV3L1 SYNE1 SYNGAP1 TARS3 TFIP11 TRIM37 TRIP11 TTC17 TTC7B UBA3 UQCRC1 USP11 VIM VPS54 WARS1 WASHC4 WDR13 WDR59 XRN2 ZBTB43 ZBTB47 ZNF202 ZNF365
Entrez ID		5339	1826
HPRD ID		03180	03953
Ensembl ID		ENSG00000178209	ENSG00000171587
Uniprot IDs		A0A8I5KSD5 A0A8I5KUE3 H0YDN1 Q15149	O60469
PDB IDs		1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I	6ZR7
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoskeleton Organization Organelle Organization Developmental Process Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Cytoskeleton Regulation Of Cellular Localization Cell Junction Assembly Cell Projection Focal Adhesion Cell Junction Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Neuregulin Binding Cytosol Regulation Of Cellular Component Organization Hemidesmosome Assembly Cell-substrate Junction Assembly Regulation Of Protein Catabolic Process Nail Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteolysis Cell-substrate Junction Organization Positive Regulation Of Catabolic Process Negative Regulation Of Neuron Projection Development Positive Regulation Of Biosynthetic Process Spectrin-associated Cytoskeleton Hemidesmosome Regulation Of Cellular Component Size Cell Projection Organization Neuron Projection Morphogenesis Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Regulation Of Neuron Projection Development Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Spectrin Cellular Component Assembly Cell Projection Morphogenesis Cytoplasm Ubiquitin Protein Ligase Binding Cell-cell Adhesion Cadherin Binding Positive Regulation Of Membrane Depolarization Basal Plasma Membrane Cellular Developmental Process Skin Morphogenesis	Cytoskeleton Organelle Organization Cytoplasm Cytoskeleton Organization Regulation Of Cellular Component Organization Cytosol Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Intracellular Protein Localization Regulation Of Cell Projection Organization Cellular Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Axonogenesis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nervous System Development Supramolecular Fiber Organization Cell Projection Actin Filament Binding Protein Binding Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Neurogenesis Establishment Of Protein Localization Identical Protein Binding Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Epithelial Cell Development Protein Transport Postsynaptic Density Retrograde Axonal Transport Intracellular Transport Microtubule-based Process Positive Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport Actin Binding Cytoskeleton-dependent Intracellular Transport Intermediate Filament Developmental Process Neuron Projection Microtubule Structural Constituent Of Cytoskeleton Microtubule Cytoskeleton Organization Intermediate Filament Organization Transport Along Microtubule Axon Intermediate Filament Cytoskeleton Cadherin Binding
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