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PKM and CDK4
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
PKM
CDK4
Description
pyruvate kinase M1/2
cyclin dependent kinase 4
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Rough Endoplasmic Reticulum
Cytosol
Cilium
Vesicle
Secretory Granule Lumen
Extracellular Exosome
Extracellular Vesicle
Ficolin-1-rich Granule Lumen
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
Bicellular Tight Junction
Membrane
Nuclear Membrane
Cyclin D1-CDK4 Complex
Cyclin D2-CDK4 Complex
Cyclin D3-CDK4 Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Transcription Coactivator Activity
RNA Binding
MRNA Binding
Catalytic Activity
Protein Tyrosine Kinase Activity
Pyruvate Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
MHC Class II Protein Complex Binding
Potassium Ion Binding
Histone H3T11 Kinase Activity
Protein Homodimerization Activity
Cadherin Binding
Metal Ion Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Transferase Activity
Cyclin Binding
Protein Serine Kinase Activity
Biological Process
Glycolytic Process
Chromatin Remodeling
Regulation Of Translation
Programmed Cell Death
Cellular Response To Insulin Stimulus
Positive Regulation Of Transcription By RNA Polymerase II
Canonical Glycolysis
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Cytoplasmic Translation
G1/S Transition Of Mitotic Cell Cycle
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Fibroblast Proliferation
Cell Division
Regulation Of Cell Cycle
Regulation Of Transcription Initiation By RNA Polymerase II
Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-4
Cellular Response To Phorbol 13-acetate 12-myristate
Cellular Response To Ionomycin
Pathways
Neutrophil degranulation
Negative Regulation of CDH1 Gene Transcription
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Meiotic recombination
Transcriptional regulation of granulopoiesis
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drug-mediated inhibition of CDK4/CDK6 activity
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Pyruvic acid
L-Phospholactate
2-Phosphoglycolic Acid
6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
Indoprofen
Copper
Polydatin
Artenimol
Purvalanol
Alvocidib
Palbociclib
Ribociclib
Abemaciclib
Fostamatinib
Trilaciclib
Diseases
Malignant melanoma
Glioma
Cervical cancer
GWAS
Aspartate aminotransferase levels (
33547301
)
Brain morphology (MOSTest) (
32665545
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Rheumatoid arthritis (
24390342
30423114
)
Interacting Genes
71 interacting genes:
ANXA7
APP
ARAF
ARX
AURKB
CCR4
CDC25A
CDK4
CEBPA
CLIC6
CTNNB1
DANCR
DDX39B
DLC1
DUX4
EGLN3
ENO3
EPM2A
EXOSC5
FGFR1
FXR1
FXR2
GRB7
HERC1
HIF1A
HOXA1
HSP90AA1
HULC
KPNA1
LINC01554
LMO7
LNX1
MAPK1
MBNL1
MDM2
MECOM
MYL2
MYOC
NAGK
NDRG1
NXT2
OGT
OLFM2
OTUB2
PAX8
PDE4B
PIN1
POLE2
PRKN
PTEN
RAF1
RAP1B
RCC1
RELA
RPP14
SHBG
SMN1
SORBS2
STUB1
SUMO1
SUMO2
TERF1
TINF2
TK1
TP53
TRIM35
TRIM63
UBE3A
UCHL5
USP7
YWHAQ
136 interacting genes:
AGAP2
AKT1
ANKRD12
ANXA7
APLP1
APP
ARAF
ARID4A
ARNT
ATP5F1B
BAG6
BCL11A
BECN1
BIRC5
BMPR1B
BRCA1
CAMK1
CAPNS1
CCND1
CCND2
CCND3
CCNE1
CD44
CDC37
CDC45
CDC6
CDC7
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CEBPA
CIB1
CNOT7
CNTN2
DAZAP2
DDAH2
DUSP9
EIF4EBP2
EPHA2
ERBB2
FARP2
FBXO8
FGFR4
FOXM1
FZR1
GLIS2
GRM1
H1-0
H1-1
H1-3
HGF
HIF1A
HMGXB3
HOOK1
HSP90AB1
IFI27
IGF1R
IKZF3
IL15RA
INCA1
KDELR2
LATS2
LNX2
LUC7L2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MAPRE2
MARCKS
MCM2
MDM4
MET
MYOD1
MZF1
NCOA2
NF2
NOL12
OGDHL
ORC3
OTX2
PDGFRA
PGD
PIAS1
PKM
POLD1
PPP2R1B
PRKAR1A
PSMD10
PTMA
QARS1
RAF1
RASSF1
RB1
RBL1
RBL2
RFC1
RFC4
RPL34
SENP3
SERTAD1
SETDB1
SHOX2
SKP1
SLBP
SMAD2
SMAD3
SNCA
SPOP
STK11
STUB1
TEAD2
TERT
TGFBR1
TK1
TP53
TRMT2A
TSC1
TSPYL2
UBE3A
UBTF
UHRF2
USP17L2
USP51
VTA1
WDR33
YBX3
ZBTB16
ZNF101
ZNF219
ZNF335
ZNF655
Entrez ID
5315
1019
HPRD ID
01529
00447
Ensembl ID
ENSG00000067225
ENSG00000135446
Uniprot IDs
A0A804F6T5
A0A804F729
A0A8V8TNX9
B4DNK4
P14618
V9HWB8
P11802
PDB IDs
1T5A
1ZJH
3BJF
3BJT
3G2G
3GQY
3GR4
3H6O
3ME3
3SRD
3SRF
3SRH
3U2Z
4B2D
4FXF
4FXJ
4G1N
4JPG
4QG6
4QG8
4QG9
4QGC
4RPP
4WJ8
4YJ5
5X0I
5X1V
5X1W
6B6U
6GG3
6GG4
6GG5
6GG6
6JFB
6NU1
6NU5
6NUB
6TTF
6TTH
6TTI
6TTQ
6V74
6V75
6V76
6WP3
6WP4
6WP5
6WP6
7L21
8G2E
8HGF
8HMQ
8HMR
8HMS
8HMU
8X4R
2W96
2W99
2W9F
2W9Z
3G33
5FWK
5FWL
5FWM
5FWP
6P8E
6P8F
6P8G
6P8H
7SJ3
Enriched GO Terms of Interacting Partners
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Nucleus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Positive Regulation Of Protein Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Modification Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Telomere Maintenance
Regulation Of Protein Modification Process
Cytosol
Positive Regulation Of Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Signal Transduction
Post-translational Protein Modification
Regulation Of Intracellular Signal Transduction
Macromolecule Metabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of Proteolysis
Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
Positive Regulation Of Chromosome Organization
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Intracellular Signaling Cassette
Nucleoplasm
Response To Xenobiotic Stimulus
Glutamatergic Synapse
Ubiquitin Protein Ligase Binding
Positive Regulation Of Transcription By RNA Polymerase II
Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Enzyme Binding
Regulation Of Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Regulation Of Chromosome Organization
Regulation Of DNA Metabolic Process
ERBB Signaling Pathway
Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Nucleus
Regulation Of Cell Population Proliferation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Catalytic Activity
Negative Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Modification Process
Regulation Of Phosphorus Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Kinase Activity
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Phosphorylation
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Nucleoplasm
Negative Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Protein Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Cycle Process
Cellular Response To Stress
Protein Kinase Binding
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
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Tagcloud (Intersection)
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