PKM and MDM2

  • Number of citations of the paper that reports this interaction (PMID 20195357)
  • 18
  • Data Source:
  • BioGRID (pull down, affinity chromatography technology)

PKM

MDM2

Gene Name pyruvate kinase, muscle MDM2 proto-oncogene, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 35 interactors: ANXA7 APP ARAF CDK4 CDKN1A EGLN3 EXOSC5 GRB7 HERC1 HIF1A LMO7 LNX1 MDM2 MYOC NAGK NDRG1 NXT2 OLFM2 PAX8 PIN1 POLE2 RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 TERF1 TINF2 TK1 TRIM63 UCHL5 YWHAQ 185 interactors: ABL1 ADRB2 ADRBK1 AKT1 ANKRD17 APEX1 APP AR ARRB2 ATF3 ATF4 ATM ATP2A2 AURKA BAIAP2L1 BRINP1 BTRC CANX CASP2 CASP3 CCAR1 CCNG1 CDH1 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CTBP2 CWC25 DAPK1 DAPK3 DAXX DHFR DLG4 DNAJB4 DYRK2 E2F1 EID1 EP300 ESR1 EZR FOXO1 G3BP2 GADD45A GCAT GLTSCR2 GNL3 GORAB GSK3B GTF2E1 GTF2E2 HDAC1 HIF1A HIPK2 HIST2H2BE HIST3H3 HLA-DMB HRSP12 HSP90B1 IGF1R IRF1 IRF2 JMY JUN JUND KAT2B KAT5 LMO7 MDM4 MED1 MKRN3 MS4A1 MTBP MYD88 MYDGF NACA NCL NOTCH1 NPM1 NR3C1 NUMB PAK6 PBX1 PDE4D PDIA3 PDLIM7 PGAM2 PHF7 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RABL6 RAD23A RANBP1 RANBP2 RASSF1 RB1 RBM38 RCHY1 RNF10 RNF126 RNF8 RPL11 RPL26 RPL5 RPS23 RPS27A RPS3 RPS7 RRM2B RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SENP3 SESN2 SET SETDB1 SHPK SMARCA2 SMARCA4 SMARCE1 SORBS2 SREK1 SRSF11 SUMO1 TAF1 TBP TCAP TERT TOP1 TP53 TP73 TPR TPT1 TRAF5 TRIM23 TRIM27 TRIM4 TRIM9 TSC22D3 TSG101 UBB UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2L3 UBE2M UBE2U UBE2Z UBE3A UBQLN4 UBTF USP2 USP7 WT1 XPC YY1AP1 ZNF133
Entrez ID 5315 4193
HPRD ID 01529 01272
Ensembl ID ENSG00000067225 ENSG00000135679
Uniprot IDs B4DNK4 P14618 A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0
PDB IDs 1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4JV7 4JV9 4JVE 4JVR 4JWR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
acutely  amplitudes  applications  aspartate  blockade  ca1  changing  channel  clamp  coapplication  combinations  consequence  currents  heterodimeric  hippocampal  inside  mg2  nmda  nr1a  nr2a  nr2b  opening  patch  patches  potentiated  potentiation  probability  sensitivities  voltage 
abundance  bound  cbp  coactivator  destabilizer  directed  e1a  endogenous  h1  implies  implying  interactions  intimately  naturally  normally  occurring  operate  overproducing  p300  p53  regard  serves  stability  stabilizing  steps  taken  translates  turnover  underscored 
Tagcloud (Difference) ?
acutely  amplitudes  applications  aspartate  blockade  ca1  changing  channel  clamp  coapplication  combinations  consequence  currents  heterodimeric  hippocampal  inside  mg2  nmda  nr1a  nr2a  nr2b  opening  patch  patches  potentiated  potentiation  probability  sensitivities  voltage 
abundance  bound  cbp  coactivator  destabilizer  directed  e1a  endogenous  h1  implies  implying  interactions  intimately  naturally  normally  occurring  operate  overproducing  p300  p53  regard  serves  stability  stabilizing  steps  taken  translates  turnover  underscored 
Tagcloud (Intersection) ?