PKM and LMO7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PKM	LMO7
Description		pyruvate kinase M1/2	LIM domain 7
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Cilium Vesicle Secretory Granule Lumen Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen	Ubiquitin Ligase Complex Nucleus Nuclear Envelope Cytoplasm Mitochondrion Cytosol Focal Adhesion Cell Surface Apical Plasma Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Transcription Coactivator Activity RNA Binding MRNA Binding Catalytic Activity Protein Tyrosine Kinase Activity Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Histone H3T11 Kinase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	Glycolytic Process Chromatin Remodeling Regulation Of Translation Programmed Cell Death Cellular Response To Insulin Stimulus Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Cytoplasmic Translation	Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process
Pathways		Neutrophil degranulation Negative Regulation of CDH1 Gene Transcription	Neddylation Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Indoprofen Copper Polydatin Artenimol
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301)	Age-related hearing impairment ( 34108613) Cutaneous melanoma or hair colour ( 32341527) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29449654 33627673) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Intraocular pressure ( 29617998 29785010 30054594 31959993) Mean corpuscular hemoglobin ( 32888494) Multiple system atrophy (pathologically confirmed) ( 27629089) Obsessive-compulsive disorder ( 30456828) Type 1 diabetes ( 21980299)
Interacting Genes		71 interacting genes: ANXA7 APP ARAF ARX AURKB CCR4 CDC25A CDK4 CEBPA CLIC6 CTNNB1 DANCR DDX39B DLC1 DUX4 EGLN3 ENO3 EPM2A EXOSC5 FGFR1 FXR1 FXR2 GRB7 HERC1 HIF1A HOXA1 HSP90AA1 HULC KPNA1 LINC01554 LMO7 LNX1 MAPK1 MBNL1 MDM2 MECOM MYL2 MYOC NAGK NDRG1 NXT2 OGT OLFM2 OTUB2 PAX8 PDE4B PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 STUB1 SUMO1 SUMO2 TERF1 TINF2 TK1 TP53 TRIM35 TRIM63 UBE3A UCHL5 USP7 YWHAQ	15 interacting genes: ABCA1 ANXA1 CALM1 DAPK3 DSCR9 EMD LRIG3 MDM2 PKM RHOU SRPK2 SUMO2 TBK1 UBAC2 YWHAG
Entrez ID		5315	4008
HPRD ID		01529	05078
Ensembl ID		ENSG00000067225	ENSG00000136153
Uniprot IDs		A0A804F6T5 A0A804F729 A0A8V8TNX9 B4DNK4 P14618 V9HWB8	A0A0A0MTE2 E9PMT2 F8J2B5 F8WD26 Q8WWI1
PDB IDs		1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6JFB 6NU1 6NU5 6NUB 6TTF 6TTH 6TTI 6TTQ 6V74 6V75 6V76 6WP3 6WP4 6WP5 6WP6 7L21 8G2E 8HGF 8HMQ 8HMR 8HMS 8HMU 8X4R	2EAQ
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Telomere Maintenance Regulation Of Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Signal Transduction Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Positive Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Signaling Cassette Nucleoplasm Response To Xenobiotic Stimulus Glutamatergic Synapse Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Chromosome Organization Regulation Of DNA Metabolic Process ERBB Signaling Pathway Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle	Vesicle Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Export From Nucleus SUMO Transferase Activity Regulation Of Signal Transduction Protein Metabolic Process Protein Modification Process Cellular Response To Hormone Stimulus Regulation Of Cell Shape Presynaptic Cytosol Regulation Of Intracellular Protein Transport Amyloid Fibril Formation Positive Regulation Of Translation Positive Regulation Of Gene Expression Intracellular Signal Transduction Regulation Of Translation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Signal Transduction Response To Nutrient Levels Sphingolipid Floppase Activity Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Myosin II Filament Organization TMEM240-body Regulation Of Protein Localization Response To Formaldehyde Cellular Response To Vitamin B1 Peptidyl-serine Phosphorylation Positive Regulation Of Translational Initiation Regulation Of Establishment Of Protein Localization Protein Sumoylation Presynapse Spindle Response To Vitamin B3 Regulation Of Multicellular Organismal Process Regulation Of Transport Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Alpha-beta T Cell Differentiation Response To Hormone Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Cycle G1/S Phase Transition Cilium Regulation Of Cell Morphogenesis Regulation Of Cell Cycle Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Post-transcriptional Regulation Of Gene Expression
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