PKM and RCC1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PKM	RCC1
Gene Name		pyruvate kinase, muscle	regulator of chromosome condensation 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cilium Extracellular Matrix Vesicle Extracellular Vesicular Exosome	Nuclear Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Magnesium Ion Binding Pyruvate Kinase Activity Protein Binding ATP Binding MHC Class II Protein Complex Binding Potassium Ion Binding Poly(A) RNA Binding	Chromatin Binding Ran Guanyl-nucleotide Exchange Factor Activity Protein Binding Nucleosomal DNA Binding Histone Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Pathogenesis Programmed Cell Death Phosphorylation Small Molecule Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Viral Process Positive Regulation Of Ran GTPase Activity Spindle Assembly Cell Division
Pathways			HIV Life Cycle Rev-mediated nuclear export of HIV RNA HIV Infection Nuclear import of Rev protein Rev-mediated nuclear export of HIV RNA Host Interactions of HIV factors Interactions of Rev with host cellular proteins Late Phase of HIV Life Cycle
Drugs		Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2\',3\':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
Diseases
GWAS
Protein-Protein Interactions		35 interactors: ANXA7 APP ARAF CDK4 CDKN1A EGLN3 EXOSC5 GRB7 HERC1 HIF1A LMO7 LNX1 MDM2 MYOC NAGK NDRG1 NXT2 OLFM2 PAX8 PIN1 POLE2 RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 TERF1 TINF2 TK1 TRIM63 UCHL5 YWHAQ	50 interactors: ACTB APLP1 BAG6 CCT7 CDK1 CDK2AP2 CHGB CHKA CSAD CSNK1A1 DDAH2 DYNC1I1 FAF1 FLAD1 GNB2 HADHB HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HMGA1 HOXD8 KMT2B KPNA3 KPNA4 KPNB1 LRIF1 NGFR NTMT1 NUDT21 NUP98 PDHB PKM PTMA RAN RANBP1 RANBP3 RPA1 SDF4 SPRED1 TLE1 TP53 TRMT2A TUBB3 UNC119 USP4 WIZ XPO1 ZNF135
Entrez ID		5315	1104
HPRD ID		01529	01559
Ensembl ID		ENSG00000067225	ENSG00000180198
Uniprot IDs		B4DNK4 P14618	P18754 Q5T081
PDB IDs		1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG	1A12 1I2M
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stress Regulation Of Signaling Intestinal Epithelial Cell Maturation Cellular Response To Hypoxia Telomere Maintenance Via Telomere Lengthening Cellular Response To Decreased Oxygen Levels Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Neurotrophin Signaling Pathway Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Response To Organic Substance Response To Organic Cyclic Compound Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Proteolysis Regulation Of Cell Cycle Response To Hormone Response To Inorganic Substance Response To Steroid Hormone Nervous System Development Regulation Of Cellular Component Organization Cell Maturation Response To Hypoxia Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Phase Transition Skeletal Muscle Adaptation Negative Regulation Of Telomere Maintenance G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway	Protein Localization To Nucleus Protein Import Into Nucleus Nuclear Import Intracellular Transport Of Virus Protein Localization To Organelle Protein Import Nucleocytoplasmic Transport Nuclear Transport Cell Cycle Mitotic Cell Cycle DNA Packaging Cellular Component Assembly Protein Complex Assembly Cell Cycle Process Chromatin Assembly Cellular Localization Cellular Protein Localization Chromatin Organization NLS-bearing Protein Import Into Nucleus Viral Process Protein Localization Ribosomal Small Subunit Export From Nucleus Chromatin Assembly Or Disassembly DNA Conformation Change Cellular Nitrogen Compound Metabolic Process Chromosome Organization Viral Life Cycle Mitotic Cell Cycle Process Cellular Metabolic Process Positive Regulation Of Cell Aging Establishment Of Protein Localization To Organelle Organelle Organization Establishment Of Protein Localization Ribosomal Large Subunit Export From Nucleus Nitrogen Compound Metabolic Process Intracellular Transport Ribosomal Subunit Export From Nucleus DNA Replication-dependent Nucleosome Assembly Protein Targeting Nucleosome Organization DNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process 'de Novo' Posttranslational Protein Folding Cellular Macromolecular Complex Assembly 'de Novo' Protein Folding Base-excision Repair DNA Methylation On Cytosine Protein Transport Protein-DNA Complex Assembly
Tagcloud ?		acutely amplitudes applications aspartate blockade ca1 changing channel clamp coapplication combinations consequence currents heterodimeric hippocampal inside mg2 nmda nr1a nr2a nr2b opening patch patches potentiated potentiation probability sensitivities voltage	almost cellulose chromosome column condensation consistently cytoplasm digestion dispersed dnase eluted encode kd located locates maturation mitotic nacl nuclei onset p45 prepared presumably putative regulating regulator released sequential synthetic
Tagcloud (Difference) ?		acutely amplitudes applications aspartate blockade ca1 changing channel clamp coapplication combinations consequence currents heterodimeric hippocampal inside mg2 nmda nr1a nr2a nr2b opening patch patches potentiated potentiation probability sensitivities voltage	almost cellulose chromosome column condensation consistently cytoplasm digestion dispersed dnase eluted encode kd located locates maturation mitotic nacl nuclei onset p45 prepared presumably putative regulating regulator released sequential synthetic
Tagcloud (Intersection) ?