PKM and RCC1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PKM	RCC1
Description		pyruvate kinase M1/2	regulator of chromosome condensation 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Cilium Vesicle Secretory Granule Lumen Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Transcription Coactivator Activity RNA Binding MRNA Binding Catalytic Activity Protein Tyrosine Kinase Activity Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Histone H3T11 Kinase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding	DNA Binding Chromatin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Nucleosome Binding Nucleosomal DNA Binding Histone Binding Sulfate Binding Protein Heterodimerization Activity
	Biological Process	Glycolytic Process Chromatin Remodeling Regulation Of Translation Programmed Cell Death Cellular Response To Insulin Stimulus Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Cytoplasmic Translation	G1/S Transition Of Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Membrane Reassembly Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Viral Process Spindle Assembly Cell Division Regulation Of Mitotic Spindle Assembly
Pathways		Neutrophil degranulation Negative Regulation of CDH1 Gene Transcription	Rev-mediated nuclear export of HIV RNA Nuclear import of Rev protein Postmitotic nuclear pore complex (NPC) reformation
Drugs		Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Indoprofen Copper Polydatin Artenimol
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301)	Night sleep phenotypes ( 27126917) Systolic blood pressure ( 30578418)
Interacting Genes		71 interacting genes: ANXA7 APP ARAF ARX AURKB CCR4 CDC25A CDK4 CEBPA CLIC6 CTNNB1 DANCR DDX39B DLC1 DUX4 EGLN3 ENO3 EPM2A EXOSC5 FGFR1 FXR1 FXR2 GRB7 HERC1 HIF1A HOXA1 HSP90AA1 HULC KPNA1 LINC01554 LMO7 LNX1 MAPK1 MBNL1 MDM2 MECOM MYL2 MYOC NAGK NDRG1 NXT2 OGT OLFM2 OTUB2 PAX8 PDE4B PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 STUB1 SUMO1 SUMO2 TERF1 TINF2 TK1 TP53 TRIM35 TRIM63 UBE3A UCHL5 USP7 YWHAQ	50 interacting genes: ACTB APLP1 BAG6 CCT7 CDK1 CDK2AP2 CEBPA CHGB CHKA CSAD CSNK1A1 DDAH2 DYNC1I1 ERCC6 FAF1 FBXO7 FLAD1 GNB2 H2AC18 H2AC20 H2BC21 H3C1 HADHB HMGA1 HOXD8 KMT2B KPNA3 LRIF1 NGFR NTMT1 NUDT21 NUP98 OGT PDHB PKM PTMA RAN RANBP1 RANBP3 SDF4 SPRED1 SUMO2 TLE1 TRMT2A TUBB3 UNC119 USP4 WIZ XPO1 ZNF135
Entrez ID		5315	1104
HPRD ID		01529	01559
Ensembl ID		ENSG00000067225	ENSG00000180198
Uniprot IDs		A0A804F6T5 A0A804F729 A0A8V8TNX9 B4DNK4 P14618 V9HWB8	A0A0S2Z3I4 A0A0S2Z404 P18754 Q5T081
PDB IDs		1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6JFB 6NU1 6NU5 6NUB 6TTF 6TTH 6TTI 6TTQ 6V74 6V75 6V76 6WP3 6WP4 6WP5 6WP6 7L21 8G2E 8HGF 8HMQ 8HMR 8HMS 8HMU 8X4R	1A12 1I2M 5E1B 5E1D 5E1M 5E1O 5E2A 5E2B 5TBK 6DUB 8UX1
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Telomere Maintenance Regulation Of Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Signal Transduction Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Positive Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Signaling Cassette Nucleoplasm Response To Xenobiotic Stimulus Glutamatergic Synapse Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Chromosome Organization Regulation Of DNA Metabolic Process ERBB Signaling Pathway Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle	Chromatin Organization Nucleoplasm Nucleus Chromatin Remodeling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Structural Constituent Of Chromatin Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleosome Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Kinetochore Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Protein Heterodimerization Activity Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Protein Export From Nucleus Ribosomal Large Subunit Export From Nucleus Chromosome Positive Regulation Of DNA Metabolic Process Ribosomal Small Subunit Export From Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of DNA Replication Cytosol Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Nuclear Envelope Ribosomal Subunit Export From Nucleus Extracellular Exosome Nuclear Export Nuclear Export Signal Receptor Activity Protein Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteolysis TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Biosynthetic Process Nuclear Retinoic Acid Receptor Binding Pyruvate Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Nucleus MRNA Cleavage And Polyadenylation Specificity Factor Complex
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