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PKM and HIF1A
Number of citations of the paper that reports this interaction (PubMedID
21620138
)
28
Data Source:
BioGRID
(affinity chromatography technology, pull down)
PKM
HIF1A
Description
pyruvate kinase M1/2
hypoxia inducible factor 1 subunit alpha
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Rough Endoplasmic Reticulum
Cytosol
Cilium
Vesicle
Secretory Granule Lumen
Extracellular Exosome
Extracellular Vesicle
Ficolin-1-rich Granule Lumen
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Nuclear Body
Nuclear Speck
Motile Cilium
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Axon Cytoplasm
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Transcription Coactivator Activity
RNA Binding
MRNA Binding
Catalytic Activity
Protein Tyrosine Kinase Activity
Pyruvate Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
MHC Class II Protein Complex Binding
Potassium Ion Binding
Histone H3T11 Kinase Activity
Protein Homodimerization Activity
Cadherin Binding
Metal Ion Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA-binding Transcription Repressor Activity
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Nuclear Receptor Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
Hsp90 Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
Transcription Regulator Activator Activity
Biological Process
Glycolytic Process
Chromatin Remodeling
Regulation Of Translation
Programmed Cell Death
Cellular Response To Insulin Stimulus
Positive Regulation Of Transcription By RNA Polymerase II
Canonical Glycolysis
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Cytoplasmic Translation
Response To Reactive Oxygen Species
Angiogenesis
Blood Vessel Development
Response To Hypoxia
Intracellular Glucose Homeostasis
Neural Crest Cell Migration
Epithelial To Mesenchymal Transition
Embryonic Placenta Development
B-1 B Cell Homeostasis
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Chondrocyte Differentiation
Glandular Epithelial Cell Differentiation
Glandular Epithelial Cell Maturation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Outflow Tract Morphogenesis
Cardiac Ventricle Morphogenesis
Lactate Metabolic Process
Regulation Of Glycolytic Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Apoptotic Process
Signal Transduction
Neuroblast Proliferation
Lactation
Visual Learning
Response To Iron Ion
Regulation Of Gene Expression
Vascular Endothelial Growth Factor Production
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Response To Muscle Activity
Positive Regulation Of Macroautophagy
Axonal Transport Of Mitochondrion
Neural Fold Elevation Formation
Cerebral Cortex Development
Cell Differentiation
Negative Regulation Of Ossification
Bone Mineralization
Negative Regulation Of Bone Mineralization
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
TOR Signaling
Negative Regulation Of TOR Signaling
Intracellular Oxygen Homeostasis
Positive Regulation Of Chemokine Production
Regulation Of Transforming Growth Factor Beta2 Production
Collagen Metabolic Process
Cellular Response To Oxidative Stress
Embryonic Hemopoiesis
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Cell Population Proliferation
Hemoglobin Biosynthetic Process
Glucose Homeostasis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Growth
Positive Regulation Of Transcription By RNA Polymerase II
Muscle Cell Cellular Homeostasis
Positive Regulation Of Hormone Biosynthetic Process
Blood Vessel Morphogenesis
Digestive Tract Morphogenesis
Camera-type Eye Morphogenesis
Cartilage Development
Neuron Apoptotic Process
Elastin Metabolic Process
Intestinal Epithelial Cell Maturation
Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
Iris Morphogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of Chemokine-mediated Signaling Pathway
Regulation Of Thymocyte Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Cellular Response To Interleukin-1
Cellular Response To Hypoxia
Dopaminergic Neuron Differentiation
Mesenchymal Cell Apoptotic Process
Hypoxia-inducible Factor-1alpha Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Nitric Oxide Metabolic Process
Regulation Of Protein Neddylation
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
Neutrophil degranulation
Negative Regulation of CDH1 Gene Transcription
Regulation of gene expression by Hypoxia-inducible Factor
Cellular response to hypoxia
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
NOTCH1 Intracellular Domain Regulates Transcription
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
PTK6 Expression
PTK6 promotes HIF1A stabilization
Neddylation
STAT3 nuclear events downstream of ALK signaling
Regulation of PD-L1(CD274) transcription
Drugs
Pyruvic acid
L-Phospholactate
2-Phosphoglycolic Acid
6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
Indoprofen
Copper
Polydatin
Artenimol
Carvedilol
Hydralazine
2-Methoxyestradiol
ENMD-1198
PX-478
FG-2216
Vadadustat
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Interacting Genes
71 interacting genes:
ANXA7
APP
ARAF
ARX
AURKB
CCR4
CDC25A
CDK4
CEBPA
CLIC6
CTNNB1
DANCR
DDX39B
DLC1
DUX4
EGLN3
ENO3
EPM2A
EXOSC5
FGFR1
FXR1
FXR2
GRB7
HERC1
HIF1A
HOXA1
HSP90AA1
HULC
KPNA1
LINC01554
LMO7
LNX1
MAPK1
MBNL1
MDM2
MECOM
MYL2
MYOC
NAGK
NDRG1
NXT2
OGT
OLFM2
OTUB2
PAX8
PDE4B
PIN1
POLE2
PRKN
PTEN
RAF1
RAP1B
RCC1
RELA
RPP14
SHBG
SMN1
SORBS2
STUB1
SUMO1
SUMO2
TERF1
TINF2
TK1
TP53
TRIM35
TRIM63
UBE3A
UCHL5
USP7
YWHAQ
133 interacting genes:
AKT1
APEX1
AR
ARNT
ARNT2
ATM
AURKA
BAP1
BMAL1
BNIP3
CASR
CCND2
CDC34
CDK4
CDK6
CDKN2A
CDKN2B
CHD4
CITED2
COPS5
CREB3L1
CREBBP
CSNK1D
CSNK2A1
CTNNB1
DAP3
E2F7
EAF2
EGLN1
EGLN2
EGLN3
EIF5A2
EP300
EPHA2
EPO
ESRRA
ESRRB
ESRRG
ETV4
F12
FBXL16
FBXO8
FGFR4
FZR1
GATA3
GLIS2
HDAC1
HDAC2
HDAC3
HDAC5
HIF1A-AS2
HIF1AN
HIF3A
HNF4A
HSP90AA1
IKBKG
ISG15
JUN
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
L3MBTL3
LATS2
LINC01139
LRRK2
MAFG
MAFK
MAP2K3
MAP2K5
MAPK1
MAPK3
MAX
MCL1
MCM7
MDM2
MTA1
MYC
NAA10
NAA11
NBN
NCOA1
NCOA2
NDN
NEDD8
NF2
NQO1
NR4A1
OS9
PER1
PGK1
PKM
PLD1
PLD2
PLK3
PPP1R13L
PRKACA
PSMA7
PTBP1
PTK6
RACGAP1
RACK1
RB1
RORA
RUNX2
RWDD3
SAT1
SEPTIN9
SIRT2
SMAD3
SNHG11
SP1
SSX4
STAT3
STK11
SUCO
SUMO1
TEAD2
TP53
TSGA10
UBE2D1
UBE2I
UBE3B
USP19
USP20
USP28
VBP1
VEGFA
VHL
VHLL
VRK1
ZC3H12A
Entrez ID
5315
3091
HPRD ID
01529
04517
Ensembl ID
ENSG00000067225
ENSG00000100644
Uniprot IDs
A0A804F6T5
A0A804F729
A0A8V8TNX9
B4DNK4
P14618
V9HWB8
D0VY79
Q16665
PDB IDs
1T5A
1ZJH
3BJF
3BJT
3G2G
3GQY
3GR4
3H6O
3ME3
3SRD
3SRF
3SRH
3U2Z
4B2D
4FXF
4FXJ
4G1N
4JPG
4QG6
4QG8
4QG9
4QGC
4RPP
4WJ8
4YJ5
5X0I
5X1V
5X1W
6B6U
6GG3
6GG4
6GG5
6GG6
6JFB
6NU1
6NU5
6NUB
6TTF
6TTH
6TTI
6TTQ
6V74
6V75
6V76
6WP3
6WP4
6WP5
6WP6
7L21
8G2E
8HGF
8HMQ
8HMR
8HMS
8HMU
8X4R
1H2K
1H2L
1H2M
1L3E
1L8C
1LM8
1LQB
2ILM
3HQR
3HQU
4AJY
4H6J
5JWP
5L9B
5L9V
5LA9
5LAS
6GFX
6GMR
6YW3
7LVS
7QGS
8HE0
8HE3
Enriched GO Terms of Interacting Partners
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Nucleus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Positive Regulation Of Protein Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Modification Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Telomere Maintenance
Regulation Of Protein Modification Process
Cytosol
Positive Regulation Of Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Signal Transduction
Post-translational Protein Modification
Regulation Of Intracellular Signal Transduction
Macromolecule Metabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of Proteolysis
Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
Positive Regulation Of Chromosome Organization
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Intracellular Signaling Cassette
Nucleoplasm
Response To Xenobiotic Stimulus
Glutamatergic Synapse
Ubiquitin Protein Ligase Binding
Positive Regulation Of Transcription By RNA Polymerase II
Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Enzyme Binding
Regulation Of Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Regulation Of Chromosome Organization
Regulation Of DNA Metabolic Process
ERBB Signaling Pathway
Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle
Nucleoplasm
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of Metabolic Process
Intracellular Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
DNA-binding Transcription Factor Binding
Regulation Of Intracellular Signal Transduction
Chromatin
Regulation Of Developmental Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Response To Oxygen Levels
Response To Stress
Response To Decreased Oxygen Levels
Regulation Of Cell Cycle
Response To Hypoxia
Regulation Of Signaling
Regulation Of Cell Communication
Protein Modification Process
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Tagcloud (Intersection)
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