PKM and OLFM2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PKM	OLFM2
Gene Name		pyruvate kinase, muscle	olfactomedin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cilium Extracellular Matrix Vesicle Extracellular Vesicular Exosome	Extracellular Region Cell Junction Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Synapse
	Molecular Function	Magnesium Ion Binding Pyruvate Kinase Activity Protein Binding ATP Binding MHC Class II Protein Complex Binding Potassium Ion Binding Poly(A) RNA Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Pathogenesis Programmed Cell Death Phosphorylation Small Molecule Metabolic Process	Protein Secretion
Pathways
Drugs		Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2\',3\':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
Diseases
GWAS			Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		35 interactors: ANXA7 APP ARAF CDK4 CDKN1A EGLN3 EXOSC5 GRB7 HERC1 HIF1A LMO7 LNX1 MDM2 MYOC NAGK NDRG1 NXT2 OLFM2 PAX8 PIN1 POLE2 RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 TERF1 TINF2 TK1 TRIM63 UCHL5 YWHAQ	11 interactors: BLOC1S6 EIF1 FANCF GNB5 KRTAP10-3 NBAS PKM ROBO2 RPS6 SRSF5 ST13
Entrez ID		5315	93145
HPRD ID		01529	10127
Ensembl ID		ENSG00000067225	ENSG00000105088
Uniprot IDs		B4DNK4 P14618	K7EIS8 O95897
PDB IDs		1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stress Regulation Of Signaling Intestinal Epithelial Cell Maturation Cellular Response To Hypoxia Telomere Maintenance Via Telomere Lengthening Cellular Response To Decreased Oxygen Levels Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Neurotrophin Signaling Pathway Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Response To Organic Substance Response To Organic Cyclic Compound Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Proteolysis Regulation Of Cell Cycle Response To Hormone Response To Inorganic Substance Response To Steroid Hormone Nervous System Development Regulation Of Cellular Component Organization Cell Maturation Response To Hypoxia Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Phase Transition Skeletal Muscle Adaptation Negative Regulation Of Telomere Maintenance G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway	Ovulation Cycle Process Negative Regulation Of Negative Chemotaxis Female Gonad Development Reproductive Structure Development Reproductive System Development Ovulation Cycle Development Of Primary Female Sexual Characteristics MRNA Metabolic Process Apoptotic Process Involved In Luteolysis Negative Regulation Of Protein Refolding Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Negative Chemotaxis Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Axon Midline Choice Point Recognition Chaperone Cofactor-dependent Protein Refolding Luteolysis Ribonucleoprotein Complex Assembly Negative Regulation Of Voltage-gated Calcium Channel Activity Oogenesis Stage Activation-induced Cell Death Of T Cells Secretion Of Lysosomal Enzymes Intracellular Transport Cytoplasmic Transport RNA Catabolic Process Axon Choice Point Recognition Developmental Process Involved In Reproduction Pigment Granule Maturation Synaptic Vesicle Docking Endosome To Melanosome Transport Multicellular Organismal Reproductive Process Olfactory Bulb Interneuron Development T Cell Proliferation Involved In Immune Response Gonad Development Translational Initiation Development Of Primary Sexual Characteristics Cellular Pigment Accumulation Multicellular Organism Reproduction Ribosomal Small Subunit Assembly Dosage Compensation By Inactivation Of X Chromosome Golgi Vesicle Transport Dosage Compensation Positive Regulation Of Pigment Cell Differentiation
Tagcloud ?		acutely amplitudes applications aspartate blockade ca1 changing channel clamp coapplication combinations consequence currents heterodimeric hippocampal inside mg2 nmda nr1a nr2a nr2b opening patch patches potentiated potentiation probability sensitivities voltage
Tagcloud (Difference) ?		acutely amplitudes applications aspartate blockade ca1 changing channel clamp coapplication combinations consequence currents heterodimeric hippocampal inside mg2 nmda nr1a nr2a nr2b opening patch patches potentiated potentiation probability sensitivities voltage
Tagcloud (Intersection) ?