PKM and CLIC6

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PKM	CLIC6
Description		pyruvate kinase M1/2	chloride intracellular channel 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Cilium Vesicle Secretory Granule Lumen Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen	Cytoplasm Plasma Membrane Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Transcription Coactivator Activity RNA Binding MRNA Binding Catalytic Activity Protein Tyrosine Kinase Activity Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Histone H3T11 Kinase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding	Chloride Channel Activity Oxidoreductase Activity D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding
	Biological Process	Glycolytic Process Chromatin Remodeling Regulation Of Translation Programmed Cell Death Cellular Response To Insulin Stimulus Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Cytoplasmic Translation	Monoatomic Ion Transport Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Neutrophil degranulation Negative Regulation of CDH1 Gene Transcription
Drugs		Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Indoprofen Copper Polydatin Artenimol
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301)	Asthma ( 31959851) Breast cancer ( 31757997) Epigenetic age acceleration in alcohol use disorder ( 31466081) Hippocampal volume ( 29274321) Psoriasis ( 25903422) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		71 interacting genes: ANXA7 APP ARAF ARX AURKB CCR4 CDC25A CDK4 CEBPA CLIC6 CTNNB1 DANCR DDX39B DLC1 DUX4 EGLN3 ENO3 EPM2A EXOSC5 FGFR1 FXR1 FXR2 GRB7 HERC1 HIF1A HOXA1 HSP90AA1 HULC KPNA1 LINC01554 LMO7 LNX1 MAPK1 MBNL1 MDM2 MECOM MYL2 MYOC NAGK NDRG1 NXT2 OGT OLFM2 OTUB2 PAX8 PDE4B PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 STUB1 SUMO1 SUMO2 TERF1 TINF2 TK1 TP53 TRIM35 TRIM63 UBE3A UCHL5 USP7 YWHAQ	27 interacting genes: ACTB ALDH5A1 ARG2 ATRX CLIC4 DRD2 DRD3 DRD4 EEF1A1 FCGR1A GFPT2 HUWE1 LGI1 MYO1E NFE2L2 NISCH OXR1 PGK1 PKM PPRC1 TAF12 TUBGCP5 UBE4A ZNF18 ZNF224 ZNF234 ZNF439
Entrez ID		5315	54102
HPRD ID		01529	10836
Ensembl ID		ENSG00000067225	ENSG00000159212
Uniprot IDs		A0A804F6T5 A0A804F729 A0A8V8TNX9 B4DNK4 P14618 V9HWB8	Q96NY7
PDB IDs		1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6JFB 6NU1 6NU5 6NUB 6TTF 6TTH 6TTI 6TTQ 6V74 6V75 6V76 6WP3 6WP4 6WP5 6WP6 7L21 8G2E 8HGF 8HMQ 8HMR 8HMS 8HMU 8X4R
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Telomere Maintenance Regulation Of Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Signal Transduction Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Positive Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Signaling Cassette Nucleoplasm Response To Xenobiotic Stimulus Glutamatergic Synapse Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Chromosome Organization Regulation Of DNA Metabolic Process ERBB Signaling Pathway Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Response To Histamine Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Arachidonate Secretion G Protein-coupled Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dopamine Binding Positive Regulation Of Neurotransmitter Uptake Long-chain Fatty Acid Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Behavior Behavioral Response To Ethanol Regulation Of Dopamine Receptor Signaling Pathway Circadian Regulation Of Gene Expression Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Protein Secretion Prepulse Inhibition G Protein-coupled Receptor Internalization Locomotory Behavior Regulation Of Amine Transport Adult Locomotory Behavior Negative Regulation Of Cytosolic Calcium Ion Concentration Ubiquitin-ubiquitin Ligase Activity Response To Morphine Fatty Acid Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Response To Oxidative Stress Canonical Glycolysis Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Regulation Of Cellular Response To Hypoxia Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Secretory Granule Lumen Glucose Catabolic Process Regulation Of Transcription By RNA Polymerase II Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Transport Dopamine Metabolic Process Ficolin-1-rich Granule Lumen Regulation Of Response To Oxidative Stress Response To Amphetamine Regulation Of Cellular Response To Stress
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