PKM and OTUB2

Number of citations of the paper that reports this interaction (PubMedID 34671086)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, imaging technique, pull down)

		PKM	OTUB2
Description		pyruvate kinase M1/2	OTU deubiquitinase, ubiquitin aldehyde binding 2
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Cilium Vesicle Secretory Granule Lumen Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen	Nucleus
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Transcription Coactivator Activity RNA Binding MRNA Binding Catalytic Activity Protein Tyrosine Kinase Activity Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Histone H3T11 Kinase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Binding
	Biological Process	Glycolytic Process Chromatin Remodeling Regulation Of Translation Programmed Cell Death Cellular Response To Insulin Stimulus Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Cytoplasmic Translation	Proteolysis Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Neutrophil degranulation Negative Regulation of CDH1 Gene Transcription	Ovarian tumor domain proteases
Drugs		Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Indoprofen Copper Polydatin Artenimol
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301)	Aspartate aminotransferase levels ( 33547301)
Interacting Genes		71 interacting genes: ANXA7 APP ARAF ARX AURKB CCR4 CDC25A CDK4 CEBPA CLIC6 CTNNB1 DANCR DDX39B DLC1 DUX4 EGLN3 ENO3 EPM2A EXOSC5 FGFR1 FXR1 FXR2 GRB7 HERC1 HIF1A HOXA1 HSP90AA1 HULC KPNA1 LINC01554 LMO7 LNX1 MAPK1 MBNL1 MDM2 MECOM MYL2 MYOC NAGK NDRG1 NXT2 OGT OLFM2 OTUB2 PAX8 PDE4B PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 STUB1 SUMO1 SUMO2 TERF1 TINF2 TK1 TP53 TRIM35 TRIM63 UBE3A UCHL5 USP7 YWHAQ	43 interacting genes: APP ARRDC3 CDIP1 CPSF6 DAZAP2 FAM168A GLI2 KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 MKRN1 NEDD8 PHLDA2 PKM PLEKHB2 PMEPA1 RBCK1 REL RFFL RNF126 SIAH1 SPART TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 U2AF2 UBC UBE2N USP21 USP28
Entrez ID		5315	78990
HPRD ID		01529	07620
Ensembl ID		ENSG00000067225	ENSG00000089723
Uniprot IDs		A0A804F6T5 A0A804F729 A0A8V8TNX9 B4DNK4 P14618 V9HWB8	Q96DC9
PDB IDs		1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6JFB 6NU1 6NU5 6NUB 6TTF 6TTH 6TTI 6TTQ 6V74 6V75 6V76 6WP3 6WP4 6WP5 6WP6 7L21 8G2E 8HGF 8HMQ 8HMR 8HMS 8HMU 8X4R	1TFF 4FJV 5QIO 5QIP 5QIQ 5QIR 5QIS 5QIT 5QIU 5QIV 5QIW 5QIX 5QIY 5QIZ 8CMS
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Telomere Maintenance Regulation Of Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Signal Transduction Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Positive Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Signaling Cassette Nucleoplasm Response To Xenobiotic Stimulus Glutamatergic Synapse Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Chromosome Organization Regulation Of DNA Metabolic Process ERBB Signaling Pathway Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle	Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Suppression Of Viral Release By Host Protein Modification Process Innate Immune Response Protein K63-linked Ubiquitination Defense Response To Symbiont Defense Response To Other Organism Host-mediated Suppression Of Symbiont Invasion Response To Other Organism Zinc Ion Binding Transferase Activity Ubiquitin-protein Transferase Activity Transcription Coactivator Activity Response To External Biotic Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Metabolic Process Canonical NF-kappaB Signal Transduction Defense Response Regulation Of Intracellular Signal Transduction Response To Virus Defense Response To Virus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Metal Ion Binding Immune Response Positive Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Cytosol Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Non-canonical NF-kappaB Signal Transduction Protein K48-linked Ubiquitination Host-mediated Perturbation Of Symbiont Process Negative Regulation Of Viral Transcription Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Modulation Of Process Of Another Organism Regulation Of Viral Transcription Collateral Sprouting In Absence Of Injury Proteasomal Protein Catabolic Process
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