PKM and EGLN3

Number of citations of the paper that reports this interaction (PMID 21620138)
118

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PKM	EGLN3
Gene Name		pyruvate kinase, muscle	egl-9 family hypoxia-inducible factor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cilium Extracellular Matrix Vesicle Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Pyruvate Kinase Activity Protein Binding ATP Binding MHC Class II Protein Complex Binding Potassium Ion Binding Poly(A) RNA Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Pathogenesis Programmed Cell Death Phosphorylation Small Molecule Metabolic Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways			Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs		Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2\',3\':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
Diseases
GWAS
Protein-Protein Interactions		35 interactors: ANXA7 APP ARAF CDK4 CDKN1A EGLN3 EXOSC5 GRB7 HERC1 HIF1A LMO7 LNX1 MDM2 MYOC NAGK NDRG1 NXT2 OLFM2 PAX8 PIN1 POLE2 RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 TERF1 TINF2 TK1 TRIM63 UCHL5 YWHAQ	22 interactors: ABI2 ADRB2 ATF4 EFHC2 EPAS1 FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK6 MAPK7 NCAPH2 OS9 PKM PRPF19 REL SERTAD1 SIAH2 SQSTM1 TTC23L WDR83
Entrez ID		5315	112399
HPRD ID		01529	06972
Ensembl ID		ENSG00000067225	ENSG00000129521
Uniprot IDs		B4DNK4 P14618	Q9H6Z9
PDB IDs		1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stress Regulation Of Signaling Intestinal Epithelial Cell Maturation Cellular Response To Hypoxia Telomere Maintenance Via Telomere Lengthening Cellular Response To Decreased Oxygen Levels Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Neurotrophin Signaling Pathway Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Response To Organic Substance Response To Organic Cyclic Compound Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Proteolysis Regulation Of Cell Cycle Response To Hormone Response To Inorganic Substance Response To Steroid Hormone Nervous System Development Regulation Of Cellular Component Organization Cell Maturation Response To Hypoxia Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Phase Transition Skeletal Muscle Adaptation Negative Regulation Of Telomere Maintenance G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway	Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Signal Transduction Negative Regulation Of Cell Death Regulation Of Cellular Response To Oxidative Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway RNA Metabolic Process Signaling Cellular Response To Stimulus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cell Communication Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Neuron Death MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of Neuron Death Toll-like Receptor 3 Signaling Pathway Gene Expression Regulation Of Protein Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription, DNA-templated MAPK Cascade Positive Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Transcription, DNA-templated
Tagcloud ?		acutely amplitudes applications aspartate blockade ca1 changing channel clamp coapplication combinations consequence currents heterodimeric hippocampal inside mg2 nmda nr1a nr2a nr2b opening patch patches potentiated potentiation probability sensitivities voltage	altering avenue cyclin d1 deubiquitinase egln1 egln2 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x
Tagcloud (Difference) ?		acutely amplitudes applications aspartate blockade ca1 changing channel clamp coapplication combinations consequence currents heterodimeric hippocampal inside mg2 nmda nr1a nr2a nr2b opening patch patches potentiated potentiation probability sensitivities voltage	altering avenue cyclin d1 deubiquitinase egln1 egln2 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x
Tagcloud (Intersection) ?