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PDE1B and POT1
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
PDE1B
POT1
Description
phosphodiesterase 1B
protection of telomeres 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Neuronal Cell Body
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Shelterin Complex
Molecular Function
Cyclic-nucleotide Phosphodiesterase Activity
3',5'-cyclic-nucleotide Phosphodiesterase Activity
3',5'-cyclic-AMP Phosphodiesterase Activity
Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity
Protein Binding
Calmodulin Binding
Phosphoric Diester Hydrolase Activity
Hydrolase Activity
Metal Ion Binding
3',5'-cyclic-GMP Phosphodiesterase Activity
Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity
DNA Binding
Protein Binding
Telomerase Inhibitor Activity
DEAD/H-box RNA Helicase Binding
Telomeric DNA Binding
Single-stranded Telomeric DNA Binding
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
G-rich Strand Telomeric DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
G-rich Single-stranded DNA Binding
Biological Process
Response To Amphetamine
Signal Transduction
Locomotory Behavior
Visual Learning
Monocyte Differentiation
Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Dopamine Catabolic Process
Serotonin Metabolic Process
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Negative Regulation Of CAMP/PKA Signal Transduction
Telomere Maintenance
Telomere Maintenance Via Telomerase
Telomere Capping
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of DNA Strand Elongation
Telomeric D-loop Disassembly
Establishment Of Protein Localization To Telomere
Positive Regulation Of Telomeric D-loop Disassembly
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Cam-PDE 1 activation
cGMP effects
G alpha (s) signalling events
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Caffeine
Caffeine
Nicardipine
Felodipine
Papaverine
Bepridil
S,S-(2-Hydroxyethyl)Thiocysteine
Trapidil
Diseases
GWAS
Post bronchodilator FEV1 in COPD (
26634245
)
Chronic lymphocytic leukemia (
24292274
28165464
)
Cutaneous malignant melanoma (
26237428
)
Leukocyte telomere length (
31171785
32109421
)
Refractive error (
32231278
)
Response to selective serotonin reuptake inhibitors and depression (
27622933
)
Telomere length (
33941849
)
Interacting Genes
2 interacting genes:
POT1
UBE3A
166 interacting genes:
ACD
ACOT7
ACTB
ACTN4
ACY1
AFAP1L2
AHCY
AHNAK
AIPL1
ALDH1A1
ALDH3A1
AMPD2
ANKMY2
ANXA2
ANXA4
APPL2
ARHGDIA
ARID3B
ARRB1
BAG3
BCAS2
BIN2
C2orf74
CALD1
CAMK1D
CCDC32
CCDC9
CCM2
CFL1
CFL2
CKB
CLIC3
CNST
CORO1A
COX6A2
CPNE3
CPPED1
CRK
CRYGS
CSNK2B
CYP4F11
DBN1
DBNL
DCX
DDX19B
DNPH1
DOK2
DPP3
DPYSL3
ECI1
EEF1D
EIF3G
EIF4B
ENO2
ENSA
EPB41L1
EVL
FAM131B
FBP1
FES
GAMT
GAPDH
GAS2L1
GFPT2
GNMT
GPA33
GPR52
GRN
H2AC20
HAAO
HLCS
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA1A
IFRD2
IL1RN
ISYNA1
IVL
KHDRBS1
KIAA1191
KRT18
LAMC3
LASP1
LDHA
LDHB
MADD
MAGEA4
MAP4
MAP4K2
MAP7
MDM2
MICA
MT1X
MVK
MVP
MYO5C
NAP1L1
NCDN
NOL3
NUDC
NUDCD2
NXNL1
PACSIN1
PACSIN2
PAGE2
PAGE5
PAK4
PALM
PCP4
PDE1B
PDLIM2
PEX5
PFKP
PGLS
PGM1
PGM2
PHYHD1
PHYKPL
PIPOX
PRMT7
PROSER2
PYM1
RBKS
RECQL4
RGS14
RHOU
RIF1
RPAP1
RPSA
RTN4
SARS1
SBDS
SERTAD1
SH3BP1
SNCG
STIP1
STUB1
SULT1B1
SULT1C2
SULT4A1
SYAP1
TAGLN
TBCD
TERF1
TMSB10
TMSB4Y
TNKS
TOMM34
TPI1
TPP1
TRIM16
TRIP10
TUBB2A
TUBB4B
TWF2
WIPI2
XAGE2
YWHAE
YWHAG
ZBED2
ZBTB49
ZFP36L1
ZNF32
ZNF790
Entrez ID
5153
25913
HPRD ID
01388
07572
Ensembl ID
ENSG00000123360
ENSG00000128513
Uniprot IDs
B3KX78
B4DK72
Q01064
A8MTK3
Q5MJ33
Q9NUX5
PDB IDs
1TAZ
4NPV
4NPW
5B25
5UOY
5UP0
5W6E
1XJV
3KJO
3KJP
5H65
5UN7
7QXB
7QXS
7S1O
7S1T
7S1U
8SH0
8SH1
8SOJ
8SOK
Enriched GO Terms of Interacting Partners
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Ribonucleotide Binding
Sperm Entry
Positive Regulation Of Golgi Lumen Acidification
Positive Regulation Of DNA Strand Elongation
Positive Regulation Of Telomeric D-loop Disassembly
G-rich Single-stranded DNA Binding
Regulation Of Golgi Lumen Acidification
Positive Regulation Of Telomeric Loop Disassembly
8-hydroxy-2'-deoxyguanosine DNA Binding
Telomeric G-quadruplex DNA Binding
Telomeric D-loop Binding
Telomere Assembly
Alpha DNA Polymerase:primase Complex
Positive Regulation Of Cellular PH Reduction
Single-stranded Telomeric DNA Binding
DNA Replication, Synthesis Of Primer
Positive Regulation Of Protein Localization To Lysosome
Shelterin Complex
Telomerase Inhibitor Activity
Establishment Of Protein Localization To Telomere
DEAD/H-box RNA Helicase Binding
Nuclear Telomere Cap Complex
Telomeric D-loop Disassembly
Prostate Gland Growth
G-rich Strand Telomeric DNA Binding
Telomeric Loop Disassembly
Progesterone Receptor Signaling Pathway
Telomere Capping
Regulation Of DNA Strand Elongation
Androgen Receptor Signaling Pathway
Negative Regulation Of Telomere Maintenance Via Telomerase
Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
DNA Metabolic Process
DNA Replication Initiation
DNA-directed RNA Polymerase Activity
Postsynaptic Cytosol
Telomere Maintenance Via Telomere Lengthening
Telomeric DNA Binding
RNA-templated DNA Biosynthetic Process
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Biosynthetic Process
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Response To Progesterone
DNA-directed RNA Polymerase Complex
Negative Regulation Of Telomere Maintenance
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of DNA Biosynthetic Process
Cytoplasm
Cytosol
Extracellular Exosome
Cytoskeleton Organization
Actin Filament Organization
Cytoskeleton
Protein Binding
Cadherin Binding
Nicotinamide Nucleotide Metabolic Process
Purine-containing Compound Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Supramolecular Fiber Organization
Cellular Response To Heat
Actin Binding
Carbohydrate Catabolic Process
Response To Heat
Pyruvate Metabolic Process
Organelle Organization
Glycolytic Process
Nucleoside Phosphate Metabolic Process
ADP Catabolic Process
Vesicle
Purine Nucleotide Metabolic Process
Identical Protein Binding
Generation Of Precursor Metabolites And Energy
Purine Ribonucleoside Diphosphate Catabolic Process
Small Molecule Metabolic Process
Ribonucleoside Diphosphate Catabolic Process
ADP Metabolic Process
Response To Temperature Stimulus
Nucleoside Diphosphate Catabolic Process
Purine Nucleotide Catabolic Process
Ficolin-1-rich Granule Lumen
Glucose Metabolic Process
Microtubule Cytoskeleton Organization
Nucleoside Phosphate Catabolic Process
Actin Filament-based Process
Actin Cytoskeleton Organization
Monocarboxylic Acid Metabolic Process
Nucleotide Metabolic Process
Negative Regulation Of Cellular Component Organization
Cytoskeletal Protein Binding
Protein Sequestering Activity
Focal Adhesion
Catabolic Process
Monosaccharide Metabolic Process
Actin Monomer Binding
Cellular Response To Raffinose
Nucleotide Catabolic Process
Organic Acid Metabolic Process
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Tagcloud (Intersection)
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