PDE1B

Name	phosphodiesterase 1B
Structure
Novel Interactors	1 novel interactors: PRIM1
Interactors	2 interactors: POT1 UBE3A
GO Annotations	Cellular Component	Cytoplasm Cytosol Neuronal Cell Body
	Molecular Function	Cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Calmodulin Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Response To Amphetamine Signal Transduction Locomotory Behavior Visual Learning Monocyte Differentiation Cellular Response To Macrophage Colony-stimulating Factor Stimulus Dopamine Catabolic Process Serotonin Metabolic Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways	Cam-PDE 1 activation cGMP effects G alpha (s) signalling events
Drugs	Caffeine Caffeine Nicardipine Felodipine Papaverine Bepridil S,S-(2-Hydroxyethyl)Thiocysteine Trapidil
GWAS	Post bronchodilator FEV1 in COPD ( 26634245 )
Entrez ID	5153
HPRD ID	01388
Ensembl ID	ENSG00000123360
Uniprot IDs	B3KX78 B4DK72 Q01064
PDB IDs	1TAZ 4NPV 4NPW 5B25 5UOY 5UP0 5W6E
GO Terms Enriched among Interactors ?	Ribonucleotide Binding Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Golgi Lumen Acidification Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Alpha DNA Polymerase:primase Complex Positive Regulation Of Cellular PH Reduction Single-stranded Telomeric DNA Binding DNA Replication, Synthesis Of Primer Positive Regulation Of Protein Localization To Lysosome Shelterin Complex Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere DEAD/H-box RNA Helicase Binding Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Prostate Gland Growth G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Progesterone Receptor Signaling Pathway Telomere Capping Regulation Of DNA Strand Elongation Androgen Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Metabolic Process DNA Replication Initiation DNA-directed RNA Polymerase Activity Postsynaptic Cytosol Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding RNA-templated DNA Biosynthetic Process Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Progesterone DNA-directed RNA Polymerase Complex Negative Regulation Of Telomere Maintenance Nucleobase-containing Compound Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process