PDE1B and UBE3A

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PDE1B	UBE3A
Gene Name		phosphodiesterase 1B, calmodulin-dependent	ubiquitin protein ligase E3A
Image
Gene Ontology Annotations	Cellular Component	Cytosol Neuronal Cell Body	Proteasome Complex Nucleus Cytoplasm Cytosol
	Molecular Function	3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-dependent Cyclic-nucleotide Phosphodiesterase Activity Calmodulin Binding Metal Ion Binding Calcium- And Calmodulin-regulated 3',5'-cyclic-GMP Phosphodiesterase Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity
	Biological Process	Regulation Of Neurotransmitter Levels Response To Amphetamine CAMP Catabolic Process Apoptotic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Locomotory Behavior Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Monocyte Differentiation Cellular Response To Macrophage Colony-stimulating Factor Stimulus Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Innate Immune Response CGMP Catabolic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Sperm Entry Regulation Of Circadian Rhythm Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Ca-dependent events Signaling by GPCR CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade G alpha (s) signalling events Cam-PDE 1 activation cGMP effects Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling DAP12 signaling CaM pathway Downstream signaling of activated FGFR Nitric oxide stimulates guanylate cyclase Innate Immune System Signaling by PDGF Calmodulin induced events DAP12 interactions Signalling by NGF PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Cam-PDE 1 activation Signaling by EGFR GPCR downstream signaling Platelet homeostasis Downstream signal transduction Calmodulin induced events PLC-gamma1 signalling Signaling by EGFR in Cancer	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: POT1 UBE3A	80 interactors: ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CDKN1B CEBPZ DLG1 EAPP EID1 EIF4G1 HBA1 HPCAL4 HSPA4 JADE1 KLHL38 LCK MAGEA8 MCM7 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PDE1B PGR PML POLE4 PRDX1 PSAP PSMC3 PSMD4 RAD23A RAD23B RARA RMI1 RNF2 SACS SCAMP1 SCRIB SGK223 SHBG SMAD9 SOD1 SUMO3 TAT TBC1D14 TCF19 TP53 TRIM65 TSC2 TTC3 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBQLN2 UCHL5 YOD1 YWHAE YWHAZ
Entrez ID		5153	7337
HPRD ID		01388	03375
Ensembl ID		ENSG00000123360	ENSG00000114062
Uniprot IDs		B4DK72 Q01064 Q7Z364	Q05086 Q9BUI6 Q9H2G0
PDB IDs		1LXR 1TAZ	1C4Z 1D5F 1EQX 2KR1 4GIZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Strand Elongation Sperm Entry Telomere Formation Via Telomerase Positive Regulation Of Helicase Activity Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Prostate Gland Growth RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Protein K48-linked Ubiquitination Androgen Receptor Signaling Pathway Protein Autoubiquitination Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of DNA Replication Telomere Maintenance Ovarian Follicle Development Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway DNA Duplex Unwinding DNA Geometric Change Negative Regulation Of Chromosome Organization Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Circadian Rhythm Negative Regulation Of DNA Metabolic Process Ovulation Cycle Process Organ Growth Female Gonad Development Ovulation Cycle Development Of Primary Female Sexual Characteristics Regulation Of DNA Replication Single Fertilization Positive Regulation Of Cellular Metabolic Process	Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Catabolic Process Response To Stress Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Checkpoint Cell Death Death Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Apoptotic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Regulation Of Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle Arrest Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Proteasomal Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Regulation Of Cell Cycle Catabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint
Tagcloud ?		adjust adora2a avp cart cecal clp gng7 intramuscular ku myh7 oxt pdyn preconditioning prkcd prkch puncture ratref reproduced rgs9 rxrg s100a8 sepsis six3 slc17a6 slco1a5 sostdc1 tac1 ttr ulinastatin	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Difference) ?		adjust adora2a avp cart cecal clp gng7 intramuscular ku myh7 oxt pdyn preconditioning prkcd prkch puncture ratref reproduced rgs9 rxrg s100a8 sepsis six3 slc17a6 slco1a5 sostdc1 tac1 ttr ulinastatin	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Intersection) ?