RBCK1 and TRIM65

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		RBCK1	TRIM65
Description		RANBP2-type and C3HC4-type zinc finger containing 1	tripartite motif containing 65
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GO Annotations	Cellular Component	Cytosol LUBAC Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Sequestering Activity Ubiquitin Ligase Activator Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Immune System Process Inflammatory Response Positive Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Protein Oligomerization Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production NLRP3 Inflammasome Complex Assembly Innate Immune Response Negative Regulation Of Inflammatory Response Type I Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Night sleep phenotypes ( 27126917)	Body mass index ( 29273807) Deep white matter hyperintensities ( 32517579) Psoriasis ( 28537254) Reticulocyte count ( 32888494) White matter hyperintensities ( 30002152 32358547) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		71 interacting genes: ANKRD35 ANTXR1 APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MAP3K1 MAPKBP1 MKRN2 MTSS1 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RELA RIPPLY3 RNF181 RNF26 RNF31 SHARPIN SMURF1 SOCS6 SYCE1 TNF TNFAIP3 TP53 TRAF1 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414	15 interacting genes: ANAPC11 IFIH1 MARCHF7 MKRN3 RBCK1 RIGI SRPK1 TNRC6A TP53 UBE2D2 UBE2N UBE2U UBE2Z UBE3A VCAM1
Entrez ID		10616	201292
HPRD ID		16643	15569
Ensembl ID		ENSG00000125826	ENSG00000141569
Uniprot IDs		A0A8V8TMZ2 A6PVJ6 Q9BYM8	Q6PJ69
PDB IDs		2CRC 2LGY 4DBG 7V8E 7YUI 7YUJ 8BVL 8EAZ 8K6Q 9EGV 9EGW	7JL0 7JL2 7JL4
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Transferase Activity Catabolic Process Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Cysteine-type Peptidase Activity Ubiquitin Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Defense Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of DNA-templated Transcription Free Ubiquitin Chain Polymerization Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process	Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Protein Polyubiquitination Protein Modification Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Transferase Activity Macromolecule Metabolic Process Detection Of Virus Regulation Of Type III Interferon Production Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process MRNA Transcription Protein Autoubiquitination Proteolysis Proteasomal Protein Catabolic Process Antiviral Innate Immune Response Response To Nutrient Levels MDM2/MDM4 Family Protein Binding Cellular Response To Nutrient Levels Catabolic Process Zinc Ion Binding ATP Binding Cellular Response To Exogenous DsRNA Ubiquitin Binding Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Polyubiquitination Protein Catabolic Process Cytosol Cellular Response To DsRNA Positive Regulation Of Post-translational Protein Modification Immune Response-activating Signaling Pathway Positive Regulation Of Interferon-alpha Production Regulation Of Protein Polyubiquitination Nucleotide Binding Immune Response-regulating Signaling Pathway Response To Stress Activation Of Immune Response Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Programmed Necrotic Cell Death Response To External Biotic Stimulus Immune System Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
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