RBCK1 and SOCS6

Number of citations of the paper that reports this interaction (PMID 16643902)
10

Data Source:
HPRD (in vivo, two hybrid)

		RBCK1	SOCS6
Gene Name		RanBP-type and C3HC4-type zinc finger containing 1	suppressor of cytokine signaling 6
Image
Gene Ontology Annotations	Cellular Component	LUBAC Complex	Immunological Synapse Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Binding	Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Protein Polyubiquitination Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Protein Kinase Activity Defense Response JAK-STAT Cascade Proteasomal Protein Catabolic Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of JAK-STAT Cascade Negative Regulation Of T Cell Activation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by SCF-KIT Regulation of KIT signaling
Drugs
Diseases
GWAS			Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		46 interactors: APP ARNT2 BACH1 CREBBP IKBKG IREB2 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PARK2 PCGF2 PRKCA PSMD4 RNF181 RNF31 SOCS6 SYCE1 TNFAIP3 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7	22 interactors: ACVR1 BMPR1B EFEMP1 INSR IRS2 IRS4 KDM1A KIT PIK3R1 PIK3R2 RBCK1 RELA SMURF2 TCEB1 TCEB2 TGFBR1 TUBA1A TUBB4B UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		10616	9306
HPRD ID		16643	05491
Ensembl ID		ENSG00000125826	ENSG00000170677
Uniprot IDs		A6PVK0 Q9BYM8	O14544
PDB IDs		2CRC 2LGY 4DBG	2VIF
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Protein Metabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Type I Interferon Production Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Response To Stress Regulation Of Proteolysis Histone Modification Histone Deubiquitination Cellular Response To Stress Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K11-linked Ubiquitination Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Chromosome Organization Protein K6-linked Ubiquitination Protein K11-linked Deubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Protein Monoubiquitination Chromatin Modification Protein Autoubiquitination Negative Regulation Of Type I Interferon Production Cellular Process Regulation Of Transcription, DNA-templated	Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Growth Factor Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Cellular Response To Organic Substance Response To Insulin Response To Stimulus Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Viral Process ERBB Signaling Pathway Cellular Protein Modification Process Cellular Response To Stimulus Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Hormone Response To Stress Defense Response Regulation Of Cartilage Development Negative Regulation Of Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Tagcloud ?		1beta ali allocated attenuates autologous c3hc4 dependently dismutase histology intravenously malondialdehyde mda oalt occluded orthotopic oxidant pathologic peroxiredoxin portal prx ranbp restoring sham sod started u1 uh ul ulinastatin	6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2
Tagcloud (Difference) ?		1beta ali allocated attenuates autologous c3hc4 dependently dismutase histology intravenously malondialdehyde mda oalt occluded orthotopic oxidant pathologic peroxiredoxin portal prx ranbp restoring sham sod started u1 uh ul ulinastatin	6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2
Tagcloud (Intersection) ?