RBCK1 and IREB2

Number of citations of the paper that reports this interaction (PMID 12629548)
34

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		RBCK1	IREB2
Gene Name		RanBP-type and C3HC4-type zinc finger containing 1	iron-responsive element binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	LUBAC Complex	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Binding	RNA Binding Protein Binding Iron-responsive Element Binding Translation Repressor Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Protein Polyubiquitination Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Protoporphyrinogen IX Biosynthetic Process Iron Ion Transport Cellular Iron Ion Homeostasis Aging Post-embryonic Development Response To Iron(II) Ion Negative Regulation Of Translation Osteoclast Differentiation Response To Retinoic Acid Erythrocyte Homeostasis Intestinal Absorption Cellular Response To Hypoxia
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease ( 22080838 20173748) Obesity-related traits ( 23251661)
Protein-Protein Interactions		46 interactors: APP ARNT2 BACH1 CREBBP IKBKG IREB2 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PARK2 PCGF2 PRKCA PSMD4 RNF181 RNF31 SOCS6 SYCE1 TNFAIP3 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7	5 interactors: APP RBCK1 TERT USP53 YBX1
Entrez ID		10616	3658
HPRD ID		16643	08858
Ensembl ID		ENSG00000125826	ENSG00000136381
Uniprot IDs		A6PVK0 Q9BYM8	D3DW85 P48200
PDB IDs		2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Protein Metabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Type I Interferon Production Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Response To Stress Regulation Of Proteolysis Histone Modification Histone Deubiquitination Cellular Response To Stress Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K11-linked Ubiquitination Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Chromosome Organization Protein K6-linked Ubiquitination Protein K11-linked Deubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Protein Monoubiquitination Chromatin Modification Protein Autoubiquitination Negative Regulation Of Type I Interferon Production Cellular Process Regulation Of Transcription, DNA-templated	Posttranscriptional Regulation Of Gene Expression RNA Processing Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Age-dependent Telomere Shortening Protein Linear Polyubiquitination Telomere Formation Via Telomerase Regulation Of Extrinsic Apoptotic Signaling Pathway Telomere Maintenance Via Telomere Shortening Collateral Sprouting Axon Midline Choice Point Recognition CRD-mediated MRNA Stabilization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Telomere Assembly Neuron Remodeling Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference Positive Regulation Of Gene Expression Negative Regulation Of Necroptotic Process MRNA Processing RNA Interference Negative Regulation Of Necrotic Cell Death Replicative Senescence Regulation Of Necroptotic Process Cellular Copper Ion Homeostasis Negative Regulation Of Striated Muscle Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process RNA-dependent DNA Replication Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Gene Silencing Copper Ion Homeostasis Suckling Behavior MRNA Metabolic Process Regulation Of Necrotic Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Cellular Protein Catabolic Process MRNA Stabilization Negative Regulation Of Cellular Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Catabolic Process
Tagcloud ?		1beta ali allocated attenuates autologous c3hc4 dependently dismutase histology intravenously malondialdehyde mda oalt occluded orthotopic oxidant pathologic peroxiredoxin portal prx ranbp restoring sham sod started u1 uh ul ulinastatin
Tagcloud (Difference) ?		1beta ali allocated attenuates autologous c3hc4 dependently dismutase histology intravenously malondialdehyde mda oalt occluded orthotopic oxidant pathologic peroxiredoxin portal prx ranbp restoring sham sod started u1 uh ul ulinastatin
Tagcloud (Intersection) ?