RBCK1 and USP15

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		RBCK1	USP15
Gene Name		RanBP-type and C3HC4-type zinc finger containing 1	ubiquitin specific peptidase 15
Image
Gene Ontology Annotations	Cellular Component	LUBAC Complex	Nucleus Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitinated Histone Binding
	Biological Process	Protein Polyubiquitination Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Pathway-restricted SMAD Protein Phosphorylation Regulation Of Proteasomal Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Pulmonary function decline ( 22424883)
Protein-Protein Interactions		46 interactors: APP ARNT2 BACH1 CREBBP IKBKG IREB2 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PARK2 PCGF2 PRKCA PSMD4 RNF181 RNF31 SOCS6 SYCE1 TNFAIP3 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7	45 interactors: BAP1 BMPR1A BRAP CARD9 CCDC57 FHL1 HIST2H2BE JOSD1 MAD1L1 OTUB1 PHF7 PLA2G2A RBCK1 RNF126 RNF144B SART3 SENP3 SENP8 SMAD3 SPDL1 STAM STK33 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UBE2S UCHL1 UCHL3 USP14 USP20 USP21 USP28 USP33 USP4 USP51 USP7 USP8 YOD1
Entrez ID		10616	9958
HPRD ID		16643	05293
Ensembl ID		ENSG00000125826	ENSG00000135655
Uniprot IDs		A6PVK0 Q9BYM8	Q9Y4E8
PDB IDs		2CRC 2LGY 4DBG	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Protein Metabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Type I Interferon Production Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Response To Stress Regulation Of Proteolysis Histone Modification Histone Deubiquitination Cellular Response To Stress Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K11-linked Ubiquitination Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Chromosome Organization Protein K6-linked Ubiquitination Protein K11-linked Deubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Protein Monoubiquitination Chromatin Modification Protein Autoubiquitination Negative Regulation Of Type I Interferon Production Cellular Process Regulation Of Transcription, DNA-templated	Protein Modification By Small Protein Removal Protein Deubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteolysis Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K63-linked Deubiquitination Regulation Of Proteolysis Protein Polyubiquitination Histone Deubiquitination Protein K63-linked Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Viral Release From Host Cell Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Stress Regulation Of Protein Ubiquitination Regulation Of Protein Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Protein Monoubiquitination Protein Autoubiquitination Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Pattern Recognition Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Innate Immune Response-activating Signal Transduction
Tagcloud ?		1beta ali allocated attenuates autologous c3hc4 dependently dismutase histology intravenously malondialdehyde mda oalt occluded orthotopic oxidant pathologic peroxiredoxin portal prx ranbp restoring sham sod started u1 uh ul ulinastatin	antitumor bacterial boost challenge characterized class crucial deficiency degradation deubiquitinases dub dubs e3 enhanced induce ligase mdm2 negatively nfatc2 physiological promoted regulated regulator responses stabilized targeting targets turn ubiquitin
Tagcloud (Difference) ?		1beta ali allocated attenuates autologous c3hc4 dependently dismutase histology intravenously malondialdehyde mda oalt occluded orthotopic oxidant pathologic peroxiredoxin portal prx ranbp restoring sham sod started u1 uh ul ulinastatin	antitumor bacterial boost challenge characterized class crucial deficiency degradation deubiquitinases dub dubs e3 enhanced induce ligase mdm2 negatively nfatc2 physiological promoted regulated regulator responses stabilized targeting targets turn ubiquitin
Tagcloud (Intersection) ?