RBCK1 and USP15

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		RBCK1	USP15
Description		RANBP2-type and C3HC4-type zinc finger containing 1	ubiquitin specific peptidase 15
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GO Annotations	Cellular Component	Cytosol LUBAC Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Body
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Sequestering Activity Ubiquitin Ligase Activator Activity	Catalytic Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding SMAD Binding Ubiquitin-modified Histone Reader Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Transcription Elongation-coupled Chromatin Remodeling Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Antigen processing: Ubiquitination & Proteasome degradation	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Night sleep phenotypes ( 27126917)	Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		71 interacting genes: ANKRD35 ANTXR1 APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MAP3K1 MAPKBP1 MKRN2 MTSS1 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RELA RIPPLY3 RNF181 RNF26 RNF31 SHARPIN SMURF1 SOCS6 SYCE1 TNF TNFAIP3 TP53 TRAF1 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414	61 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 CDC73 CSNK1A1 FHL1 GEMIN4 GLUL GOLGA2 GOLGA6A GSPT1 H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PARP1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RIGI RNF126 RNF144B RNF26 SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1
Entrez ID		10616	9958
HPRD ID		16643	05293
Ensembl ID		ENSG00000125826	ENSG00000135655
Uniprot IDs		A0A8V8TMZ2 A6PVJ6 Q9BYM8	Q9Y4E8
PDB IDs		2CRC 2LGY 4DBG 7V8E 7YUI 7YUJ 8BVL 8EAZ 8K6Q 9EGV 9EGW	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1 7R2G
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Transferase Activity Catabolic Process Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Cysteine-type Peptidase Activity Ubiquitin Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Defense Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of DNA-templated Transcription Free Ubiquitin Chain Polymerization Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process	Post-translational Protein Modification Protein Modification Process Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Cysteine-type Peptidase Activity Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Peptidase Activity Protein K48-linked Deubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity DeNEDDylase Activity Catabolic Process Zinc Ion Binding Cytosol Protein Polyubiquitination Proteasomal Protein Catabolic Process Cytoplasm Deubiquitinase Activity Protein Catabolic Process Innate Immune Response Ubiquitin Binding Cysteine-type Endopeptidase Activity Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Transferase Activity Defense Response To Symbiont Metal Ion Binding Defense Response To Other Organism Response To External Biotic Stimulus Response To Stress Response To Other Organism Hydrolase Activity Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Regulation Of Signal Transduction Antiviral Innate Immune Response Regulation Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Regulation Of Double-strand Break Repair
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