RBCK1 and RNF31

Number of citations of the paper that reports this interaction (PMID 17006537)
115

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		RBCK1	RNF31
Gene Name		RanBP-type and C3HC4-type zinc finger containing 1	ring finger protein 31
Image
Gene Ontology Annotations	Cellular Component	LUBAC Complex	Cytoplasm Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex LUBAC Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Protein Polyubiquitination Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Polyubiquitination CD40 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Linear Polyubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		46 interactors: APP ARNT2 BACH1 CREBBP IKBKG IREB2 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PARK2 PCGF2 PRKCA PSMD4 RNF181 RNF31 SOCS6 SYCE1 TNFAIP3 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7	27 interactors: AES ATN1 ATXN1 ATXN7 AZI2 CCDC24 GFI1B IKBKG KIF1A KRTAP9-2 NOS3 NR0B1 NR0B2 PITX1 PRKCA RBCK1 SMAD3 SNRPC SOCS3 TRAF1 TRIM25 TSSC4 UBC UBE2D1 UBE2D3 VASN VCP
Entrez ID		10616	55072
HPRD ID		16643	11516
Ensembl ID		ENSG00000125826	ENSG00000092098
Uniprot IDs		A6PVK0 Q9BYM8	Q96EP0
PDB IDs		2CRC 2LGY 4DBG	2CT7 4DBG 4JUY
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Protein Metabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Type I Interferon Production Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Response To Stress Regulation Of Proteolysis Histone Modification Histone Deubiquitination Cellular Response To Stress Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K11-linked Ubiquitination Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Chromosome Organization Protein K6-linked Ubiquitination Protein K11-linked Deubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Protein Monoubiquitination Chromatin Modification Protein Autoubiquitination Negative Regulation Of Type I Interferon Production Cellular Process Regulation Of Transcription, DNA-templated	Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Signaling Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation RNA Biosynthetic Process Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus Regulation Of Apoptotic Process MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Organic Substance Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Protein Ubiquitination Signaling Toll-like Receptor 4 Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Response To Organic Substance Protein Modification By Small Protein Conjugation Cell Communication Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Immune System Process Apoptotic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels
Tagcloud ?		1beta ali allocated attenuates autologous c3hc4 dependently dismutase histology intravenously malondialdehyde mda oalt occluded orthotopic oxidant pathologic peroxiredoxin portal prx ranbp restoring sham sod started u1 uh ul ulinastatin	adjuvant antiestrogens arise aromatase associates atypical confirms cytosol decreases diagnostics e3 eralpha establishes estrogen facilitates initially insights ligase mono occupied promoters reduces stability stabilizes stabilizing therapeutics ubiquitin ubiquitination utmost
Tagcloud (Difference) ?		1beta ali allocated attenuates autologous c3hc4 dependently dismutase histology intravenously malondialdehyde mda oalt occluded orthotopic oxidant pathologic peroxiredoxin portal prx ranbp restoring sham sod started u1 uh ul ulinastatin	adjuvant antiestrogens arise aromatase associates atypical confirms cytosol decreases diagnostics e3 eralpha establishes estrogen facilitates initially insights ligase mono occupied promoters reduces stability stabilizes stabilizing therapeutics ubiquitin ubiquitination utmost
Tagcloud (Intersection) ?