RBCK1 and UBE2D1

Number of citations of the paper that reports this interaction (PubMedID 17006537)
43

Data Source:
BioGRID (pull down)

		RBCK1	UBE2D1
Description		RANBP2-type and C3HC4-type zinc finger containing 1	ubiquitin conjugating enzyme E2 D1
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GO Annotations	Cellular Component	Cytosol LUBAC Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Sequestering Activity Ubiquitin Ligase Activator Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Negative Regulation Of TORC1 Signaling
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Antigen processing: Ubiquitination & Proteasome degradation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Inactivation of APC/C via direct inhibition of the APC/C complex TICAM1, RIP1-mediated IKK complex recruitment APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Signaling by BMP Downstream TCR signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Ovarian tumor domain proteases Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Aberrant regulation of mitotic exit in cancer due to RB1 defects Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Night sleep phenotypes ( 27126917)	Brain imaging ( 20100581) Crohn's disease ( 21102463)
Interacting Genes		71 interacting genes: ANKRD35 ANTXR1 APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MAP3K1 MAPKBP1 MKRN2 MTSS1 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RELA RIPPLY3 RNF181 RNF26 RNF31 SHARPIN SMURF1 SOCS6 SYCE1 TNF TNFAIP3 TP53 TRAF1 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414	239 interacting genes: AMFR ANAPC11 ANXA1 ANXA7 AREL1 ARIH1 ARIH2 ARK2C ARRDC3 ASB2 ASB4 ASB9 BABAM2 BARD1 BFAR BIRC2 BIRC3 BIRC6 BIRC7 BIRC8 BRCA1 BRCC3 BRMS1 C7orf25 CADPS2 CBL CBLC CDK7 CDKN1A CHFR CNOT4 COP1 CRBN CREBBP CRYAB CTNNB1 CUL2 CUL3 CUL4A DTL DTX1 DTX2 DTX3 DTX3L DYRK2 DZIP3 EP300 EPS15 F12 FAF2 FBXL2 FBXL20 FBXO2 FBXO7 FOS FZR1 GADD45A GSK3B HDAC6 HECTD1 HECW1 HERC2 HERC3 HIF1A HSD17B10 HUWE1 ITCH KAT2B KCTD17 KDM2B KEAP1 KLHL13 KLHL2 KLHL9 LNPK LRR1 LRSAM1 LTN1 MAP3K1 MARCHF1 MARCHF2 MARCHF4 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEOX2 MGRN1 MIB1 MIB2 MID1 MID2 MKNK1 MKRN1 MKRN2 MKRN3 MUL1 NBN NEDD4 NEDD4L NEURL1 NFKBIA NHLRC1 NQO1 NR1H2 OBI1 PELI1 PJA2 PMAIP1 POLL POLM POLR2E PRKN RABGEF1 RAG1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF125 RNF126 RNF13 RNF130 RNF14 RNF144A RNF150 RNF166 RNF167 RNF168 RNF181 RNF182 RNF185 RNF2 RNF207 RNF216 RNF25 RNF26 RNF31 RNF34 RNF38 RNF4 RNF43 RNF5 RNF6 RNF7 RNF8 SH3RF1 SHPRH SIAH1 SIAH2 SIRT6 SIVA1 SKP1 SMURF1 SPOP STAM2 STUB1 TAF1D TBL1X TMEM129 TNFAIP3 TNNT1 TOM1 TOPORS TRAF2 TRAF4 TRAF6 TRAF7 TRAIP TRIM10 TRIM17 TRIM21 TRIM22 TRIM23 TRIM24 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM35 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM69 TRIM7 TRIM72 TRIM8 TRIP12 TSC22D1 UBA1 UBA6 UBASH3B UBC UBE3A UBE3C UBE4A UBOX5 UBR5 UBTD1 UFM1 UHRF1 UHRF2 USP21 UVSSA VHL WWP1 WWP2 XIAP ZNF598 ZNRF1 ZNRF2 ZNRF4 ZRANB1
Entrez ID		10616	7321
HPRD ID		16643	04267
Ensembl ID		ENSG00000125826	ENSG00000072401
Uniprot IDs		A0A8V8TMZ2 A6PVJ6 Q9BYM8	A0A087WW00 P51668
PDB IDs		2CRC 2LGY 4DBG 7V8E 7YUI 7YUJ 8BVL 8EAZ 8K6Q 9EGV 9EGW	2C4P 2YHO 3OJ4 3PTF 4AP4 4QPL 5FER 5TUT 6D4P 7ZJ3
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Transferase Activity Catabolic Process Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Cysteine-type Peptidase Activity Ubiquitin Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Defense Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of DNA-templated Transcription Free Ubiquitin Chain Polymerization Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Macromolecule Catabolic Process Zinc Ion Binding Macromolecule Metabolic Process Proteolysis Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Metal Ion Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Cytoplasm Protein Monoubiquitination Response To Stress Ubiquitin Ligase Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Immune System Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Canonical NF-kappaB Signal Transduction DNA Damage Response Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding
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